Celastrol
Celastrol is extracted from Tripterygium wilfordii. Stanford Chemicals has been providing quality Celastrol and many other natural plant extract for over 15 years.
Product Name | Celastrol |
CAS No. | 34157-83-0 |
Molecular Formula | C29H38O4 |
Molecular Weight | 450.61 |
Botanical Source | Tripterygium wilfordii |
Purity | 98% HPLC |
Appearance | Red powder |
Package | 25 kg/drum |
Storage | Stored in cool & dry places, protected from direct sunlight and heat. |
Shelf Life | 2 years |
Celastrol Safety Tips
Handling of Celastrol should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.
Related Products
-
Product Name: Triptolide
CAS No.: 38748-32-2
Molecular Formula: C20H24O6
Molecular Weight: 360.4
Purity: 98% HPLC
Package: 1g;100g;1kg;5kg
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Tripterygium Wilfordii Extract, Specification: 0.6% 1% 98% Triptolide HPLC;98% Wilforlide A HPLC;10% 50% 98% Celastrol HPLC. Botanical Source: Tripterygium Wilfordii.
References
- 1. AFM Studied the Effect of Celastrol on β1 Integrin-Mediated HUVEC Adhesion and Migration.
Ke C, Jin H, Cai J.Scanning. 2012 Dec 12. doi: 10.1002/sca.21070. [Epub ahead of print]
- 2. Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas chromatography-mass spectrometry based metabolic profiling.
Hu Y, Qi Y, Liu H, Fan G, Chai Y.Biochim Biophys Acta. 2012 Nov 8. doi:pii: S0304-4165(12)00310-8. 10.1016/j.bbagen.2012.10.024. [Epub ahead of print]
- 3. Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders.
Johnson TA, Sohn J, Inman WD, Bjeldanes LF, Rayburn K.Phytomedicine. 2012 Oct 20. doi:pii: S0944-7113(12)00352-2. 10.1016/j.phymed.2012.09.016. [Epub ahead of print]
- 4. Celastrol inhibits growth and induces apoptotic cell death in melanoma cells via the activation ROS-dependent mitochondrial pathway and the suppression of PI3K/AKT signaling.
Lee JH, Won YS, Park KH, Lee MK, Tachibana H, Yamada K, Seo KI.Apoptosis. 2012 Dec;17(12):1275-86. doi: 10.1007/s10495-012-0767-5.
- 5. Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats.
Zhang J, Li CY, Xu MJ, Wu T, Chu JH, Liu SJ, Ju WZ.J Ethnopharmacol. 2012 Oct 31;144(1):195-200. doi: 10.1016/j.jep.2012.09.005. Epub 2012 Sep 13.
- 6. Celastrol inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and invasion through suppression of NF-κB-mediated matrix metalloproteinase-9 expression.
Li GQ, Zhang Y, Liu D, Qian YY, Zhang H, Guo SY, Sunagawa M, Hisamitsu T, Liu YQ.Int Immunopharmacol. 2012 Dec;14(4):422-31. doi: 10.1016/j.intimp.2012.08.016. Epub 2012 Sep 3.
- 7. Celastrol attenuates adipokine resistin-associated matrix interaction and migration of vascular smooth muscle cells.
Kang SW, Kim MS, Kim HS, Kim Y, Shin D, Park JH, Kang YH.J Cell Biochem. 2013 Feb;114(2):398-408. doi: 10.1002/jcb.24374.
- 8. Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine.
Chen Y, Yuan L, Zhou L, Zhang ZH, Cao W, Wu Q.Int J Nanomedicine. 2012;7:4581-91. doi: 10.2147/IJN.S34991. Epub 2012 Aug 20.
- 9. The therapeutic potential of pharmacological chaperones and proteosomal inhibitors, Celastrol and MG132 in the treatment of sialidosis.
O'Leary EM, Igdoura SA.Mol Genet Metab. 2012 Sep;107(1-2):173-85. doi: 10.1016/j.ymgme.2012.07.013. Epub 2012 Jul 24.
- 10. Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells.
Lu W, Jia G, Meng X, Zhao C, Zhang L, Ren Y, Pan H, Ni Y.Life Sci. 2012 Sep 17;91(7-8):279-83. doi: 10.1016/j.lfs.2012.07.032. Epub 2012 Aug 1.
- 11. Induction of heat shock proteins in cerebral cortical cultures by celastrol.
Chow AM, Tang DW, Hanif A, Brown IR.Cell Stress Chaperones. 2012 Aug 3. [Epub ahead of print]
- 12. Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines.
Venkatesha SH, Astry B, Nanjundaiah SM, Yu H, Moudgil KD.Bioorg Med Chem. 2012 Sep 1;20(17):5229-34. doi: 10.1016/j.bmc.2012.06.050. Epub 2012 Jul 7.
- 13. Formulation, characterization, and evaluation of in vitro skin permeation and in vivo pharmacodynamics of surface-charged tripterine-loaded nanostructured lipid carriers.
Chen Y, Zhou L, Yuan L, Zhang ZH, Liu X, Wu Q.Int J Nanomedicine. 2012;7:3023-32. doi: 10.2147/IJN.S32476. Epub 2012 Jun 19.
- 14. Optimized preparation of celastrol-loaded polymeric nanomicelles using rotatable central composite design and response surface methodology.
Peng X, Wang J, Song H, Cui D, Li L, Li J, Lin L, Zhou J, Liu Y.J Biomed Nanotechnol. 2012 Jun;8(3):491-9.
- 15. Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells.
Huang S, Tang Y, Cai X, Peng X, Liu X, Zhang L, Xiang Y, Wang D, Wang X, Pan T.Biochem Biophys Res Commun. 2012 Jul 6;423(3):467-72. doi: 10.1016/j.bbrc.2012.05.143. Epub 2012 Jun 5.
- 16. Strong inhibition of celastrol towards UDP-glucuronosyl transferase (UGT) 1A6 and 2B7 indicating potential risk of UGT-based herb-drug interaction.
Zhang YS, Tu YY, Gao XC, Yuan J, Li G, Wang L, Deng JP, Wang Q, Ma RM.Molecules. 2012 Jun 5;17(6):6832-9. doi: 10.3390/molecules17066832.
- 17. [Expression, purification of poteasome subunit PSMB1 and application in screening of possible proteasome inhibitors].
Fan C, Feng L, Zhang D, Pan S, Liu X, Guo D, Fan J.Sheng Wu Gong Cheng Xue Bao. 2012 Feb;28(2):233-42. Chinese.
- 18. Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression.
Huang W, He T, Chai C, Yang Y, Zheng Y, Zhou P, Qiao X, Zhang B, Liu Z, Wang J, Shi C, Lei L, Gao K, Li H, Zhong S, Yao L, Huang ME, Lei M.PLoS One. 2012;7(5):e37693. doi: 10.1371/journal.pone.0037693. Epub 2012 May 30.
- 19. Microarray-based gene expression profiling reveals the mediators and pathways involved in the anti-arthritic activity of Celastrus-derived Celastrol.
Yu H, Venkatesha SH, Moudgil KD.Int Immunopharmacol. 2012 Aug;13(4):499-506. doi: 10.1016/j.intimp.2012.05.015. Epub 2012 Jun 2.
- 20. Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model.
Li Z, Wu X, Li J, Yao L, Sun L, Shi Y, Zhang W, Lin J, Liang D, Li Y.Int J Nanomedicine. 2012;7:2389-98. doi: 10.2147/IJN.S29945. Epub 2012 May 9.