Standard Herbal Extract

Artemisia Annua Extract Safety Tips

Handling of Artemisia Annua Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. First-time comparison of the in vitro antimalarial activity of Artemisia annua herbal tea and artemisinin.
  De Donno A, Grassi T, Idolo A, Guido M, Papadia P, Caccioppola A, Villanova L, Merendino A, Bagordo F, Fanizzi FP.Trans R Soc Trop Med Hyg. 2012 Nov;106(11):696-700. doi: 10.1016/j.trstmh.2012.07.008. Epub 2012 Sep 15.
• 2. Antihistomonal effects of artemisinin and Artemisia annua extracts in vitro could not be confirmed by in vivo experiments in turkeys and chickens.
  Thøfner IC, Liebhart D, Hess M, Schou TW, Hess C, Ivarsen E, Fretté XC, Christensen LP, Grevsen K, Engberg RM, Christensen JP.Avian Pathol. 2012 Oct;41(5):487-96. doi: 10.1080/03079457.2012.714459. Epub 2012 Sep 17.
• 3. The effect of Artemisia annua on broiler performance, on intestinal microbiota and on the course of a Clostridium perfringens infection applying a necrotic enteritis disease model.
  Engberg RM, Grevsen K, Ivarsen E, Fretté X, Christensen LP, Højberg O, Jensen BB, Canibe N.Avian Pathol. 2012;41(4):369-76. doi: 10.1080/03079457.2012.696185.
• 4. The impact of impurities in various crude A. annua extracts on the analysis of artemisinin by liquid chromatographic methods.
  Pilkington JL, Preston C, Gomes RL.J Pharm Biomed Anal. 2012 Nov;70:136-42. doi: 10.1016/j.jpba.2012.06.015. Epub 2012 Jun 18.
• 5. A Safety Assessment of the Antimalarial Herb Artemisia annua During Pregnancy in Wistar Rats.
  Abolaji AO, Eteng MU, Ebong PE, Brisibe EA, Dar A, Kabir N, Choudhary MI.Phytother Res. 2012 Jun 27. doi: 10.1002/ptr.4760. [Epub ahead of print]
• 6. Biochemical and Haematological Evaluation of Repeated Dose Exposure of Male Wistar Rats to an Ethanolic Extract of Artemisia annua.
  Eteng MU, Abolaji AO, Ebong PE, Brisibe EA, Dar A, Kabir N, Iqbal Choudhary M.Phytother Res. 2012 Jun 27. doi: 10.1002/ptr.4758. [Epub ahead of print]
• 7. The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion.
  Weathers PJ, Towler MJ.Planta Med. 2012 Jun;78(10):1024-6. doi: 10.1055/s-0032-1314949. Epub 2012 Jun 6.
• 8. Chemical composition of Artemisia annua L. leaves and antioxidant potential of extracts as a function of extraction solvents.
  Iqbal S, Younas U, Chan KW, Zia-Ul-Haq M, Ismail M.Molecules. 2012 May 21;17(5):6020-32. doi: 10.3390/molecules17056020.
• 9. Effect of sweet wormwood Artemisia annua crude leaf extracts on some biological and physiological characteristics of the lesser mulberry pyralid, Glyphodes pyloalis.
  Khosravi R, Sendi JJ, Ghadamyari M, Yezdani E.J Insect Sci. 2011;11:156. doi: 10.1673/031.011.15601.
• 10. Simultaneous isolation of artemisinin and its precursors from Artemisia annua L. by preparative RP-HPLC.
  Tian N, Li J, Liu S, Huang J, Li X, Liu Z.Biomed Chromatogr. 2012 Jun;26(6):708-13. doi: 10.1002/bmc.1719. Epub 2011 Sep 19.
• 11. Status of carbohydrate, protein and lipid profile in the mosquito larvae treated with certain phytoextracts.
  Sharma P, Mohan L, Dua KK, Srivastava CN.Asian Pac J Trop Med. 2011 Apr;4(4):301-4. doi: 10.1016/S1995-7645(11)60090-4. Epub 2011 May 29.
• 12. Cytotoxicity of ethanolic extracts of Artemisia annua to Molt-4 human leukemia cells.
  Singh NP, Ferreira JF, Park JS, Lai HC.Planta Med. 2011 Nov;77(16):1788-93. doi: 10.1055/s-0030-1271157. Epub 2011 Jun 14.
• 13. Plant extracts to control Alternaria alternata in Murcott tangor fruits.
  Carvalho DD, Alves E, Barbosa Camargos R, Ferreira Oliveira D, Soares Scolforo JR, de Carvalho DA, Sâmia Batista TR.Rev Iberoam Micol. 2011 Oct-Dec;28(4):173-8. doi: 10.1016/j.riam.2011.05.001. Epub 2011 May 13.
• 14. Sedative effects of Iranian Artemisia annua in mice: possible benzodiazepine receptors involvement.
  Emadi F, Yassa N, Hadjiakhoondi A, Beyer C, Sharifzadeh M.Pharm Biol. 2011 Aug;49(8):784-8. doi: 10.3109/13880209.2010.548389. Epub 2011 May 10.
• 15. The content of artemisinin in the Artemisia annua tea infusion.
  van der Kooy F, Verpoorte R.Planta Med. 2011 Oct;77(15):1754-6. doi: 10.1055/s-0030-1271065. Epub 2011 May 3.
• 16. In vitro activity of Artemisia annua L (Asteraceae) extracts against Rhipicephalus (Boophilus) microplus.
  Chagas AC, Georgetti CS, Carvalho CO, Oliveira MC, Rodrigues RA, Foglio MA, Magalhães PM.Rev Bras Parasitol Vet. 2011 Jan-Mar;20(1):31-5.
• 17. Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya.
  Verma G, Dua VK, Agarwal DD, Atul PK.Malar J. 2011 Feb 2;10:20. doi: 10.1186/1475-2875-10-20.
• 18. Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cδ/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.
  Wang Y, Huang ZQ, Wang CQ, Wang LS, Meng S, Zhang YC, Chen T, Fan YQ.Clin Exp Pharmacol Physiol. 2011 Jan;38(1):11-8. doi: 10.1111/j.1440-1681.2010.05454.x.
• 19. Effects of artemisinin and Artemisia extracts on Haemonchus contortus in gerbils (Meriones unguiculatus).
  Squires JM, Ferreira JF, Lindsay DS, Zajac AM.Vet Parasitol. 2011 Jan 10;175(1-2):103-8. doi: 10.1016/j.vetpar.2010.09.011. Epub 2010 Sep 16.
• 20. Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum.
  Zhang J, Ge HM, Jiao RH, Li J, Peng H, Wang YR, Wu JH, Song YC, Tan RX.Planta Med. 2010 Nov;76(16):1910-4. doi: 10.1055/s-0030-1249936. Epub 2010 May 19.

Details