Botanical Ingredient

Baicalin Safety Tips

Handling of Baicalin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats.
  Yu CP, Shia CS, Tsai SY, Hou YC.Evid Based Complement Alternat Med. 2012;2012:308018. doi: 10.1155/2012/308018. Epub 2012 Nov 1.
• 2. Anti-inflammatory effect of Sosihotang via inhibition of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.
  Oh YC, Cho WK, Jeong YH, Im GY, Lee KJ, Yang HJ, Ma JY.Food Chem Toxicol. 2012 Dec 11. doi:pii: S0278-6915(12)00868-X.  10.1016/j.fct.2012.12.006. [Epub ahead of print]
• 3. Baicalin Downregulates Porphyromonas gingivalis Lipopolysaccharide-Upregulated IL-6 and IL-8 Expression in Human Oral Keratinocytes by Negative Regulation of TLR Signaling.
  Luo W, Wang CY, Jin L.PLoS One. 2012;7(12):e51008. doi: 10.1371/journal.pone.0051008. Epub 2012 Dec 11.
• 4. [Construction on the chitosan microparticles of baicalin and comparison of transdermal diffusion in vitro of baicalin in chitosan microparticles and cream].
  Wang H, Cai Y, Han H, Wang BD, Huang YJ, Yu RM.Zhong Yao Cai. 2012 May;35(5):800-3. Chinese.
• 5. [Drug delivery systems of baicalin, baicalin-phospholipid complex and self-microemulsifying drug across caco-2 cell model].
  Chen L, Long XY, Huang SH, Wu HY, Pan SJ.Zhong Yao Cai. 2012 May;35(5):757-61. Chinese.
• 6. [Responses of Scutellaria baicalensis Georgi yield and root baicalin content to the fertilization rates of nitrogen, phosphorus, and potassium].
  Cao XY, Xu FL, Wang WL, Wang J, Huang SH, Zhang XH.Ying Yong Sheng Tai Xue Bao. 2012 Aug;23(8):2171-7. Chinese.
• 7. [Preparation of flavonoid reference standards from Scutellariae Radix under the guidance of high performance liquid chromatography-mass spectrometry analysis].
  Guo H, Yang X, Liu J, Zheng W.Se Pu. 2012 Jul;30(7):690-5. Chinese.
• 8. Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats.
  Liu SZ, Deng YX, Chen B, Zhang XJ, Shi QZ, Qiu XM.J Ethnopharmacol. 2012 Nov 23. doi:pii: S0378-8741(12)00781-7.  10.1016/j.jep.2012.11.017. [Epub ahead of print]
• 9. Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats.
  Wang Z, Hu H, Chen F, Lan K, Wang A.J Ethnopharmacol. 2012 Nov 16. doi:pii: S0378-8741(12)00769-6.  10.1016/j.jep.2012.11.008. [Epub ahead of print]
• 10. [Effects of Baicalin on an orthotopic transplantation mouse model of mismatch repair gene deficient colorectal cancer].
  Yang BL, Chen HJ, Chen YG, Gu YF, Zhang SP, Lin Q, Zhu P.Zhonghua Wai Ke Za Zhi. 2012 Sep;50(9):843-7. Chinese.
• 11. Baicalin and Scutellarin Are Proteasome Inhibitors that Specifically Target Chymotrypsin-like Catalytic Activity.
  Wu YX, Sato E, Kimura W, Miura N.Phytother Res. 2012 Nov 12. doi: 10.1002/ptr.4878. [Epub ahead of print]
• 12. Qualitative and quantitative simultaneous determination of six marker compounds in soshiho-tang by HPLC-DAD-ESI-MS.
  Yang HJ, Ma JY, Weon JB, Lee B, Ma CJ.Arch Pharm Res. 2012 Oct;35(10):1785-91. doi: 10.1007/s12272-012-1011-0. Epub 2012 Nov 9.
• 13. Baicalin attenuates proinflammatory cytokine production in oxygen-glucose deprived challenged rat microglial cells by inhibiting TLR4 signaling pathway.
  Hou J, Wang J, Zhang P, Li D, Zhang C, Zhao H, Fu J, Wang B, Liu J.Int Immunopharmacol. 2012 Dec;14(4):749-57. doi: 10.1016/j.intimp.2012.10.013. Epub 2012 Oct 29.
• 14. Baicalin and its emerging antineoplastic effects in systemic malignancies besides colorectal carcinomas.
  Kapoor S.Int J Colorectal Dis. 2012 Nov 1. [Epub ahead of print] No abstract available.
• 15. [Effects of Baicalin on HL-60 Cell Xenografts in Nude Mice and Its Mechanism].
  Zheng J, Hu JD, Huang Y, Chen YY, Li J, Chen BY.Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Oct;20(5):1066-71. Chinese.
• 16. CaMKKβ is involved in AMP-activated protein kinase activation by baicalin in LKB1 deficient cell lines.
  Ma Y, Yang F, Wang Y, Du Z, Liu D, Guo H, Shen J, Peng H.PLoS One. 2012;7(10):e47900. doi: 10.1371/journal.pone.0047900. Epub 2012 Oct 22.
• 17. A study on the use of near-infrared spectroscopy for the rapid quantification of major compounds in Tanreqing injection.
  Li W, Cheng Z, Wang Y, Qu H.Spectrochim Acta A Mol Biomol Spectrosc. 2013 Jan 15;101:1-7. doi: 10.1016/j.saa.2012.09.044. Epub 2012 Sep 28.
• 18. Water deficit affected flavonoid accumulation by regulating hormone metabolism in Scutellaria baicalensis Georgi roots.
  Yuan Y, Liu Y, Wu C, Chen S, Wang Z, Yang Z, Qin S, Huang L.PLoS One. 2012;7(10):e42946. doi: 10.1371/journal.pone.0042946. Epub 2012 Oct 15.
• 19. Synergism and rules from combination of Baicalin, Jasminoidin and Desoxycholic acid in refined Qing Kai Ling for treat ischemic stroke mice model.
  Li J, Wu RG, Meng FY, Wang Z, Wang CM, Wang YY, Zhang ZJ.PLoS One. 2012;7(9):e45811. doi: 10.1371/journal.pone.0045811. Epub 2012 Sep 26.
• 20. Activations of GABAergic signaling, HSP70 and MAPK cascades are involved in baicalin’s neuroprotection against gerbil global ischemia/reperfusion injury.
  Dai J, Chen L, Qiu YM, Li SQ, Xiong WH, Yin YH, Jia F, Jiang JY.Brain Res Bull. 2013 Jan;90:1-9. doi: 10.1016/j.brainresbull.2012.09.014. Epub 2012 Oct 2.

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