Swertiamarin

Description of Swertiamarin

Source	Swertia L.
Keywords	Diabetes, β cell, analgesia

Swertiamarin, a secoiridoid glycoside abundantly present in E. axillare, exhibits a spectrum of noteworthy biological activities, establishing itself as a multifaceted natural compound. Its oral bioavailability enhances its accessibility, making it a valuable asset in various health-related applications.

Specifications of Swertiamarin

Product Name	Swertiamarin
CAS Registry Number	17388-39-5
Molecular Formula	C16H22O10
Molecular Weight	374.3 g/mol
Purity	10-95 %
Appearance	Pale yellow powder
Package	1kg-25kg
Shelf life	2 years
Functions	anti-hyperglycemic, anti-hyperlipidemic, anti-diabetic activity, enhances β cell regeneration

Applications of Swertiamarin

1. Laboratory Research:

Anti-Inflammatory Studies: Swertiamarin’s anti-inflammatory properties make it a valuable asset in laboratory research. Scientists explore its potential in mitigating inflammatory responses, contributing to the understanding of its role in addressing various health conditions.
Anticancer Investigations: Ongoing studies delve into Swertiamarin’s potential anticancer properties. Its bioactive nature prompts researchers to explore its impact on cancer cells, paving the way for potential therapeutic interventions.
Metabolic and Cardiovascular Research: Swertiamarin’s influence on metabolic processes and cardiovascular health is a subject of interest in laboratory settings. Research endeavors aim to unravel its effects on lipid metabolism, blood glucose levels, and overall cardiovascular well-being.

2. Hair Regeneration Products:

Natural Hair Restoration: Swertiamarin emerges as a promising raw material in the realm of hair regeneration products. Its inclusion in formulations is driven by its potential to promote hair growth, strengthen follicles, and contribute to overall scalp health.
Nutrient-Rich Hair Care: Swertiamarin’s nutritive properties make it an ideal addition to hair care products. By providing essential elements for hair vitality, it contributes to the development of formulations that address concerns related to hair loss and promote natural regeneration.
Scalp Health Enhancement: The application of Swertiamarin in hair regeneration products extends to improving scalp health. Its bioactive components may play a role in maintaining a conducive environment for hair growth and overall hair wellness.

Swertiamarin Safety Tips

Handling of Swertiamarin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

Reference:

Vaijanathappa, J., and Badami, S. Antiedematogenic and free radical scavenging activity of swertiamarin isolated from Enicostemma axillare. Planta Med. 75(1), 12-17 (2009).
Saravanan, S., Islam, V.I., Thirugnanasambantham, K., et al. Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1β induced rat fibroblast-like synoviocytes. Inflamm. Res. 63(6), 451-462 (2014).
Sonawane, R.D., Vishwakarma, S.L., Lakshmi, S., et al. Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats. Mol. Cell Biochem. 340(1-2), 1-6 (2010).
Patel, T.P., Rawal, K., Soni, S., et al. Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis. Biomed. Pharmacother. 83, 785-791 (2016).
Yang, Y., Li, J., Wei, C., et al. Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice. Phytomedicine 59, 152782 (2019).