Botanical Ingredient

Shikimic Acid Safety Description

Derived from I. religiosum, shikimic acid, a cyclohexene carboxylic acid, exhibits notable effects on lipid droplet accumulation. At a concentration of 80 µM, it demonstrates a reduction in lipid droplets in both HepG2 cells and 3T3-L1 adipocytes. Additionally, at 40 µM, shikimic acid elevates phosphorylated AMPK levels and reduces MID1IP1 levels in these cells, suggesting potential implications for cellular metabolism.

Shikimic acid, sourced from star anise and existing in its anionic form shikimate, is a cyclohexane carboxylic acid, cyclohexene, and cyclitol. Beyond its cellular impact, shikimic acid’s significance lies in the shikimic acid pathway, a fundamental route for synthesizing basic amino acids in various organisms, including plants, bacteria, fungi, and algae. This pathway underscores shikimic acid’s essential role in the biosynthesis of crucial cellular components across diverse biological entities.

Specifications of Shikimic Acid

Applications of Shikimic Acid

– Essential Amino Acid Precursor: Shikimic acid is a vital biosynthetic precursor for essential amino acids like phenylalanine, tyrosine, and tryptophan, influencing crucial biological processes.

– Frontline of Plant Metabolism: Positioned at the forefront of plant metabolism, shikimic acid shapes the synthesis of diverse plant alkaloids, contributing to the medicinal properties found in various plant species.

– Biosynthesis of Plant Compounds: Shikimic acid is a key player in intricate biosynthetic pathways, participating in the formation of essential compounds such as lignin, crucial for plant structure, and flavonoids, known for their antioxidant and anti-inflammatory effects.

– Multifaceted Impact: Its involvement in synthesizing aromatic compounds underscores shikimic acid’s broad impact on the chemical composition and functional characteristics of plants, showcasing its multifaceted contributions to plant biology.

Shikimic Acid Safety Tips

Handling of Shikimic Acid should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

Reference:

1. Bohm, B.A. Shikimic Acid (3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic Acid). Chem. Rev. 65(4), 435-466 (1965).
2. Rawat, G., Tripathi, P., and Saxena, R.K. Expanding horizons of shikimic acid. Recent progress in production and its endless frontiers in application and market trends. Appl. Microbiol. Biotechnol. 97(10), 4277-4287 (2013).
3. Kim, M.J., Sim, D.Y., Lee, H.M., et al. Hypolipogenic effect of shikimic acid via inhibition of MID1IP1 and phosphorylation of AMPK/ACC. Int. J. Mol. Sci. 20(3), E582 (2019).
4. Lu, F., Yin, D., Pu, Y., et al. Shikimic acid promotes oligodendrocyte precursor cell differentiation and accelerates remyelination in mice. Neurosci. Bull. 35(3), 434-446 (2019 ).

Details