Botanical Ingredient

Berberine Safety Tips

Handling of Berberine should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats.
  Yu CP, Shia CS, Tsai SY, Hou YC.Evid Based Complement Alternat Med. 2012;2012:308018. doi: 10.1155/2012/308018. Epub 2012 Nov 1.
• 2. Analysis of active alkaloids in the Menispermaceae family by nonaqueous capillary electrophoresis-ion trap mass spectrometry.
  Chen Q, Zhang J, Zhang W, Chen Z.J Sep Sci. 2012 Dec 18. doi: 10.1002/jssc.201200678. [Epub ahead of print]
• 3. Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells.
  Hu HY, Li KP, Wang XJ, Liu Y, Lu ZG, Dong RH, Guo HB, Zhang MX.Acta Pharmacol Sin. 2012 Dec 17. doi: 10.1038/aps.2012.161. [Epub ahead of print]
• 4. Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort.
  Jiang XW, Zhang Y, Zhu YL, Zhang H, Lu K, Li FF, Peng HY.Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Dec 12. doi:pii: S2212-4403(12)01522-2.  10.1016/j.oooo.2012.09.009. [Epub ahead of print]
• 5. Effects and interaction of icariin, curculigoside, and berberine in er-xian decoction, a traditional Chinese medicinal formula, on osteoclastic bone resorption.
  Xue L, Jiao L, Wang Y, Nie Y, Han T, Jiang Y, Rahman K, Zhang Q, Qin L.Evid Based Complement Alternat Med. 2012;2012:490843. doi: 10.1155/2012/490843. Epub 2012 Nov 1.
• 6. Berberine attenuated monocyte adhesion to endothelial cells induced by oxidized low density lipoprotein via inhibition of adhesion molecule expression.
  Huang Z, Cai X, Li S, Zhou H, Chu M, Shan P, Huang W.Mol Med Report. 2013 Feb;7(2):461-5. doi: 10.3892/mmr.2012.1236. Epub 2012 Dec 14.
• 7. Study on noncovalent complexes of alkaloids with DNA duplex using electrospray ionization mass spectrometry.
  Ma L, Song F, Liu Z, Liu S.Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):51-8. doi: 10.1002/rcm.6424.
• 8. [Optimization of technology conditions from Ermiao Wan decoction by semi-bionic extraction method].
  Zhang L.Zhongguo Zhong Yao Za Zhi. 2012 Aug;37(16):2396-9. Chinese.
• 9. Berberine and its derivatives: a patent review (2009 – 2012).
  Singh IP, Mahajan S.Expert Opin Ther Pat. 2012 Dec 12. [Epub ahead of print]
• 10. Optimizing manufacture of liposomal berberine with evaluation of its antihepatoma effects in a murine xenograft model.
  Lin YC, Kuo CY, Hsu CC, Tsai WC, Li WC, Yu MC, Wen HW.Int J Pharm. 2012 Dec 3. doi:pii: S0378-5173(12)01024-1.  10.1016/j.ijpharm.2012.11.017. [Epub ahead of print]
• 11. Interaction of herbal compounds with biological targets: a case study with berberine.
  Chen XW, Di YM, Zhang J, Zhou ZW, Li CG, Zhou SF.ScientificWorldJournal. 2012;2012:708292. doi: 10.1100/2012/708292. Epub 2012 Nov 13.
• 12. A preliminary investigation of the mechanisms underlying the effect of berberine in preventing high-fat diet-induced insulin resistance in rats.
  Gu JJ, Gao FY, Zhao TY.J Physiol Pharmacol. 2012 Oct;63(5):505-13.
• 13. Preparation of micropipette tip-based molecularly imprinted monolith for selective micro-solid phase extraction of berberine in plasma and urine samples.
  Zhang W, Chen Z.Talanta. 2013 Jan 15;103:103-9. doi: 10.1016/j.talanta.2012.10.014. Epub 2012 Oct 11.
• 14. Renoprotective effects of berberine and its possible molecular mechanisms in combination with high-fat diet and low-dose streptozotocin-induced diabetic rats.
  Wang FL, Tang LQ, Yang F, Zhu LN, Cai M, Wei W.Mol Biol Rep. 2012 Nov 30. [Epub ahead of print]
• 15. A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats.
  Wang N, Feng Y, Cheung F, Chow OY, Wang X, Su W, Tong Y.BMC Complement Altern Med. 2012 Nov 29;12(1):239. [Epub ahead of print]
• 16. Correction: Berberine Reduces Fibronectin Expression by Suppressing the S1P-S1P2 Receptor Pathway in Experimental Diabetic Nephropathy Models.
  Huang K, Liu W, Lan T, Xie X, Peng J, Huang J, Wang S, Shen X, Liu P, Huang H.PLoS One. 2012;7(10). doi: 10.1371/annotation/e4e8ca0c-f6e8-4b32-aae1-b5f8e0c7ebc3. Epub 2012 Oct 25.
• 17. Antihyperglycemic effect of the traditional Chinese scutellaria-coptis herb couple and its main components in streptozotocin-induced diabetic rats.
  Liu SZ, Deng YX, Chen B, Zhang XJ, Shi QZ, Qiu XM.J Ethnopharmacol. 2012 Nov 23. doi:pii: S0378-8741(12)00781-7.  10.1016/j.jep.2012.11.017. [Epub ahead of print]
• 18. Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: A lipophilic substitute role.
  Lo CY, Hsu LC, Chen MS, Lin YJ, Chen LG, Kuo CD, Wu JY.Bioorg Med Chem Lett. 2013 Jan 1;23(1):305-9. doi: 10.1016/j.bmcl.2012.10.098. Epub 2012 Nov 1.
• 19. Preparation and Evaluation of Orally Disintegrating Tablets Containing Taste-Masked Microcapsules of Berberine Hydrochloride.
  Hu X, Li Y, Zhang E, Wang X, Xing M, Wang Q, Lei J, Huang H.AAPS PharmSciTech. 2012 Nov 22. [Epub ahead of print]
• 20. Berberine Attenuates Ischemia-Reperfusion Injury Via Regulation of Adenosine-5′-monophosphate Kinase Activity in Both Non-ischemic and Ischemic Areas of the Rat Heart.
  Chang W, Zhang M, Li J, Meng Z, Xiao D, Wei S, Chen L, Wang C, Hatch GM.Cardiovasc Drugs Ther. 2012 Dec;26(6):467-78. doi: 10.1007/s10557-012-6422-0.

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