Botanical Ingredient

Capsaicin Safety Tips

Handling of Capsaicin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Involvement of the phosphoinositide 3-kinase/Akt pathway in apoptosis induced by capsaicin in the human pancreatic cancer cell line PANC-1.
  Zhang JH, Lai FJ, Chen H, Luo J, Zhang RY, Bu HQ, Wang ZH, Lin HH, Lin SZ.Oncol Lett. 2013 Jan;5(1):43-48. Epub 2012 Oct 24.
• 2. Angiotensin II type 2 receptor (AT(2) R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons.
  Anand U, Facer P, Yiangou Y, Sinisi M, Fox M, McCarthy T, Bountra C, Korchev YE, Anand P.Eur J Pain. 2012 Dec 17. doi: 10.1002/j.1532-2149.2012.00269.x. [Epub ahead of print]
• 3. A new rat model of bone cancer pain produced by rat breast cancer cells implantation of the shaft of femur at the third trochanter level.
  Gui Q, Xu C, Zhuang L, Xia S, Chen Y, Peng P, Yu S.Cancer Biol Ther. 2012 Dec 19;14(2). [Epub ahead of print]
• 4. TRPV1, TRPV4, and the kidney.
  Kaßmann M, Harteneck C, Zhu Z, Nürnberg B, Tepel M, Gollasch M.Acta Physiol (Oxf). 2012 Dec 18. doi: 10.1111/apha.12051. [Epub ahead of print]
• 5. [Magistral prepared lidocaine-gel for topical aplication on skin].
  Sklenár Z, Horácková K, Bakhouche H, Slanar O.Ceska Slov Farm. 2012 Aug;61(4):163-8. Czech.
• 6. Bis(phenylimidazoselenazolyl) diselenide:  a compound with antinociceptive properties in mice.
  Chagas PM, Bortolatto CF, Wilhelm EA, Roehrs JA, Nogueira CW.Behav Pharmacol. 2012 Dec 14. [Epub ahead of print]
• 7. Ageing alters perivascular nerve function of mouse mesenteric arteries in vivo.
  Westcott EB, Segal SS.J Physiol. 2012 Dec 17. [Epub ahead of print]
• 8. The basic neurophysiologic concept of lower urinary tract function–the role of vanilloid TRPV1 receptors of urinary bladder afferent nerve endings.
  Juszczak K, Thor PJ.Adv Clin Exp Med. 2012 Jul-Aug;21(4):417-21.
• 9. RPF101, a new capsaicin-like analogue, disrupts the microtubule network accompanied by arrest in the G2/M phase, inducing apoptosis and mitotic catastrophe in the MCF-7 breast cancer cells.
  de-Sá-Júnior PL, Pasqualoto KF, Ferreira AK, Tavares MT, Damião MC, de Azevedo RA, Câmara DA, Pereira A, de Souza DM, Filho RP.Toxicol Appl Pharmacol. 2012 Dec 10. doi:pii: S0041-008X(12)00518-2.  10.1016/j.taap.2012.11.029. [Epub ahead of print]
• 10. New neostigmine-based behavioral mouse model of abdominal pain.
  Fichna J, Lapointe T, Chapman K, Janecka A, Vergnolle N, Altier C, Storr MA.Pharmacol Rep. 2012 Sep;64(5):1146-54.
• 11. [Peculiarities of age changes of NF200(+)-neurons in the sensory ganglia of different segmental levels after chemical deafferentation].
  [No authors listed]Morfologiia. 2012;142(4):37-42. Russian.
• 12. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.
  Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM.PLoS Genet. 2012 Dec;8(12):e1003071. doi: 10.1371/journal.pgen.1003071. Epub 2012 Dec 6.
• 13. Functional TRPV1 expression in human corneal fibroblasts.
  Yang Y, Yang H, Wang Z, Mergler S, Wolosin JM, Reinach PS.Exp Eye Res. 2012 Dec 8. doi:pii: S0014-4835(12)00331-4.  10.1016/j.exer.2012.11.004. [Epub ahead of print]
• 14. [Pronounced symptom deterioration in complex regional pain syndrome type II after isolated application of a highly concentrated capsaicin patch :  A case report.]
  Girtler R, Kloimstein H, Gustorff B.Schmerz. 2012 Dec 9. [Epub ahead of print] German.
• 15. 0.025% Capsaicin Gel for the Treatment of Painful Diabetic Neuropathy: A Randomized, Double-Blind, Crossover, Placebo-Controlled Trial.
  Kulkantrakorn K, Lorsuwansiri C, Meesawatsom P.Pain Pract. 2012 Dec 10. doi: 10.1111/papr.12013. [Epub ahead of print]
• 16. Preliminary phytochemical and antibacterial screening of Sesuvium portulacastrum in the United Arab Emirates.
  Al-Azzawi A, Alguboori A, Hachim MY, Najat M, Al Shaimaa A, Sad M.Pharmacognosy Res. 2012 Oct;4(4):219-24. doi: 10.4103/0974-8490.102269.
• 17. Histamine-induced changes in rat tracheal goblet cell mucin store and mucosal edema.
  Huang HT, Guo JJ, Huang YH, Fu YS.Histochem Cell Biol. 2012 Dec 7. [Epub ahead of print]
• 18. Evaluation through in vivo reflectance confocal microscopy of the cutaneous neurogenic inflammatory reaction induced by capsaicin in human subjects.
  C?runtu C, Boda D.J Biomed Opt. 2012 Aug 1;17(8):85003. doi: 10.1117/1.JBO.17.8.085003.
• 19. Perivagal antagonist treatment in rats selectively blocks the reflex and afferent responses of vagal lung C-fibers to intravenous agonists.
  Lin YJ, Lin YS, Lai CJ, Yuan ZF, Ruan T, Kou YR.J Appl Physiol. 2012 Dec 6. [Epub ahead of print]
• 20. Food-drug interactions: Effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats.
  Zhai XJ, Chen JG, Liu JM, Shi F, Lu YN.Food Chem Toxicol. 2012 Dec 5. doi:pii: S0278-6915(12)00852-6.  10.1016/j.fct.2012.11.045. [Epub ahead of print]

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