Botanical Ingredient

Chrysophanol Safety Tips

Handling of Chrysophanol should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. [New method of processing on Rhei Radix Et Rhizoma and study on quality control of its processing products].
  Wang ZS, Han GR, Gao F, An LN, Ji YZ.Zhong Yao Cai. 2012 May;35(5):699-702. Chinese.
• 2. Electrochemical determination of chrysophanol based on the enhancement effect of acetylene black nanoparticles.
  Zhang Y, Wang Y, Wu K, Zhang S, Zhang Y, Wan C.Colloids Surf B Biointerfaces. 2012 Oct 17;103C:94-98. doi: 10.1016/j.colsurfb.2012.10.015. [Epub ahead of print]
• 3. Comparative Pharmacokinetics of Five Rhubarb Anthraquinones in Normal and Thrombotic Focal Cerebral Ischemia-Induced Rats.
  Feng SX, Li JS, Qu LB, Shi YM, Zhao D.Phytother Res. 2012 Nov 26. doi: 10.1002/ptr.4890. [Epub ahead of print]
• 4. Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats.
  Zhao XL, Xiang J, Wan MH, Yu Q, Chen WW, Chen GY, Tang WF.J Ethnopharmacol. 2012 Nov 2. doi:pii: S0378-8741(12)00733-7.  10.1016/j.jep.2012.10.036. [Epub ahead of print]
• 5. Anthraquinone profile, antioxidant and antimicrobial activity of bark extracts of Rhamnus alaternus, R. fallax, R. intermedia and R. pumila.
  Kosalec I, Kremer D, Locatelli M, Epifano F, Genovese S, Carlucci G, Randi? M, Zovko Kon?i? M.Food Chem. 2013 Jan 15;136(2):335-41. doi: 10.1016/j.foodchem.2012.08.026. Epub 2012 Aug 23.
• 6. Triterpene saponins of Maesa lanceolata stem wood.
  Manguro LO, Lemmen P, Hao P, Wong KC.J Asian Nat Prod Res. 2012 Oct 25. [Epub ahead of print]
• 7. The Activity of Lowering Intraocular Pressure of Cassiae Seed Extract in a DBA/2J Mouse Glaucoma Model.
  Horng CT, Tsai ML, Chien ST, Kao WT, Tsai MK, Chang TH, Chen FA.J Ocul Pharmacol Ther. 2012 Oct 5. [Epub ahead of print]
• 8. Isolation and identification of Flavobacterium columnare and Streptococcus iniae antibacterial compounds from the terrestrial plant Atraphaxis laetevirens.
  Nakano H, Schrader KK, Mamonov LK, Kustova TS, Mursaliyeva VK, Cantrell CL.J Agric Food Chem. 2012 Oct 24;60(42):10415-9. doi: 10.1021/jf304155n. Epub 2012 Oct 15.
• 9. Antiviral activity of Aloe hijazensis against some haemagglutinating viruses infection and its phytoconstituents.
  Abd-Alla HI, Abu-Gabal NS, Hassan AZ, El-Safty MM, Shalaby NM.Arch Pharm Res. 2012 Aug;35(8):1347-54. doi: 10.1007/s12272-012-0804-5. Epub 2012 Sep 1.
• 10. Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction () in rats.
  Gong HL, Tang WF, Wang J, Chen GY, Huang X.Chin J Integr Med. 2012 Sep;18(9):708-13. doi: 10.1007/s11655-012-1205-9. Epub 2012 Aug 31.
• 11. A strategy for detecting absorbed bioactive compounds for quality control in the water extract of rhubarb by ultra performance liquid chromatography with photodiode array detector.
  Wang Y, Huang X, Liang QH, Fan R, Qin F, Guo Y, Yan KP, Liu W, Luo JK, Li YH, Mao XL, Liu ZQ, Zhou HH.Chin J Integr Med. 2012 Sep;18(9):690-8. doi: 10.1007/s11655-012-1053-7. Epub 2012 Aug 31.
• 12. Tautomers of anthrahydroquinones: enzymatic reduction and implications for chrysophanol, monodictyphenone, and related xanthone biosyntheses.
  Schätzle MA, Husain SM, Ferlaino S, Müller M.J Am Chem Soc. 2012 Sep 12;134(36):14742-5. doi: 10.1021/ja307151x. Epub 2012 Aug 28.
• 13. Assessment of antibacterial properties and the active ingredient of plant extracts and its effect on the performance of crucian carp (Carassius auratus gibelio var. E’erqisi, Bloch).
  Lu C, Luo X, Luo R, Chen X, Xing L, Tang Z, Li H.J Sci Food Agric. 2012 Aug 20. doi: 10.1002/jsfa.5823. [Epub ahead of print]
• 14. Chrysophanol-induced cell death (necrosis) in human lung cancer A549 cells is mediated through increasing reactive oxygen species and decreasing the level of mitochondrial membrane potential.
  Ni CH, Yu CS, Lu HF, Yang JS, Huang HY, Chen PY, Wu SH, Ip SW, Chiang SY, Lin JG, Chung JG.Environ Toxicol. 2012 Jul 30. doi: 10.1002/tox.21801. [Epub ahead of print]
• 15. [Chemical constituents of Berchemia lineate].
  Zeng XJ, Hu Y, Wen XQ, Hong AH, Cen YZ.Zhong Yao Cai. 2012 Feb;35(2):223-5. Chinese.
• 16. [A comparative study on the absorption kinetics parameters of rhubarb free anthraquinones between normal dogs and dogs with severe acute pancreatitis].
  Yang YM, Wang P, Zhang Y.Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Apr;32(4):494-8. Chinese.
• 17. [Determination of four anthraquinones in Sanhuang tablets by QAMS].
  Wang Y, Feng W, Yang F, Zhang Q, Ji L, Li D, Wang Z.Zhongguo Zhong Yao Za Zhi. 2012 Jan;37(2):212-7. Chinese.
• 18. Genetic and biosynthetic studies of the fungal prenylated xanthone shamixanthone and related metabolites in Aspergillus spp. revisited.
  Simpson TJ.Chembiochem. 2012 Jul 23;13(11):1680-8. doi: 10.1002/cbic.201200014. Epub 2012 Jun 22.
• 19. Potential feeding deterrents found in hemlock woolly adelgid, Adelges tsugae.
  Jones AC, Mullins DE, Jones TH, Salom SM.Naturwissenschaften. 2012 Jul;99(7):583-6. doi: 10.1007/s00114-012-0931-3. Epub 2012 Jun 22.
• 20. A note on the relevance of chrysophanol to food and anticancer research.
  Wiart C.Mol Nutr Food Res. 2012 Jun;56(6):843. doi: 10.1002/mnfr.201270044. No abstract available.

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