Botanical Ingredient

Colchicine Safety Tips

Handling of Colchicine should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Improved management of acute gout during hospitalization following introduction of a protocol.
  Kamalaraj N, Gnanenthiran SR, Kathirgamanathan T, Hassett GM, Gibson KA, McNeil HP.Int J Rheum Dis. 2012 Dec;15(6):512-20. doi: 10.1111/j.1756-185X.2011.01642.x. Epub 2011 Jul 28.
• 2. Emergency abdominal surgery and colchicine overdose.
  Komorowski AL, Rodil JM.J Emerg Trauma Shock. 2012 Oct;5(4):342-3. doi: 10.4103/0974-2700.102406.
• 3. Successful treatment of recurrent idiopathic plantar eccrine hidradenitis with colchicine.
  Scheer HS, Kamarashev J, Weibel L.Arch Dermatol. 2012 Dec 1;148(12):1357-9. doi: 10.1001/archdermatol.2012.2221. No abstract available.
• 4. 250 all regions of the mouse epididymis are able to phagocytize immature spermatogenic cells.
  Ramos-Ibeas P, Pericuesta E, Fernandez-Gonzalez R, Ramirez MA, Gutierrez-Adan A.Reprod Fertil Dev. 2012 Dec;25(1):272-3. doi: 10.1071/RDv25n1Ab250.
• 5. [Severe myopathy related to colchicine poisoning: a case report].
  Ferrié B, Dupouy J, Lassoued S, Oustric S, Durrieu G, Rouge-Bugat ME, Montastruc JL.Therapie. 2012 Sep-Oct;67(5):482-3. doi: 10.2515/therapie/2012062. Epub 2012 Dec 18. French.  No abstract available.
• 6. Leukopenia associated with long-term colchicine administration.
  Beggs AE, Reeves DJ, Noel NS.Am J Health Syst Pharm. 2012 Dec 15;69(24):2147-8. doi: 10.2146/ajhp120330.
• 7. Severe colchicine intoxication after self-administration of colchicine concomitantly with loxoprofen.
  Yamazaki A, Iranami H, Nishikawa K.J Anesth. 2012 Dec 8. [Epub ahead of print] No abstract available.
• 8. A descriptive analysis of patients with an emergency department diagnosis of acute pericarditis.
  Hooper AJ, Celenza A.Emerg Med J. 2012 Dec 6. [Epub ahead of print]
• 9. Synthesis of novel chromene derivatives of expected antitumor activity.
  Kandeel MM, Kamal AM, Abdelall EK, Elshemy HA.Eur J Med Chem. 2012 Nov 17;59C:183-193. doi: 10.1016/j.ejmech.2012.11.011. [Epub ahead of print]
• 10. Evaluation of drugs and stationary growth on the cell cycle of Giardia intestinalis.
  Reaume C, Moore B, Hernández P, Ruzzini A, Chlebus M, Wasserman M, Yee J.Mol Biochem Parasitol. 2012 Dec 5. doi:pii: S0166-6851(12)00280-0.  10.1016/j.molbiopara.2012.11.005. [Epub ahead of print]
• 11. Acute effect of β-sitosterol on calcium uptake mediates anti-inflammatory effect in murine activated neutrophils.
  Liz R, Zanatta L, Dos Reis GO, Horst H, Pizzolatti MG, Silva FR, Fröde TS.J Pharm Pharmacol. 2013 Jan;65(1):115-22. doi: 10.1111/j.2042-7158.2012.01568.x. Epub 2012 Oct 11.
• 12. Towards Highly Potent Cancer Agents by Modulating the C-2 Group of the Arylthioindole Class of Tubulin Polymerization Inhibitors.
  La Regina G, Bai R, Rensen WM, Di Cesare E, Coluccia A, Piscitelli F, Famiglini V, Reggio A, Nalli M, Pelliccia S, Da Pozzo E, Costa B, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Santoni A, Li J, Miranda Cona M, Chen F, Ni Y, Brancale A, Dondio G, Vultaggio S, Varasi M, Mercurio C, Martini C, Hamel E, Lavia P, Novellino E, Silvestri R.J Med Chem. 2012 Dec 5. [Epub ahead of print]
• 13. Colchicine-Induced Rhabdomyolysis Caused by Interaction With Clarithromycin in a Patient With Behçet Disease.
  Kim JB, Kim S, Yoon SY, Lee T, Lee YS, Kwon HS, Cho YS, Moon HB, Kim YG, Kim TB.J Clin Rheumatol. 2012 Dec;18(8):453-454. No abstract available.
• 14. Extremely high ferritin level after an acute myocardial infarction in an end stage renal disease patient.
  Sandhu G, Mankal P, Gupta I, Tagani A, Ranade A, Jones J, Bansal A.Clin Nephrol. 2012 Dec 4. [Epub ahead of print]
• 15. Pulsed electromagnetic field affects intrinsic and endoplasmatic reticulum apoptosis induction pathways in MonoMac6 cell line culture.
  Kaszuba-Zwoinska J, Chorobik P, Juszczak K, Zaraska W, Thor PJ.J Physiol Pharmacol. 2012 Oct;63(5):537-45.
• 16. Colchicine Semisynthetics: Chemotherapeutics for Cancer?
  Sivakumar G.Curr Med Chem. 2012 Dec 3. [Epub ahead of print]
• 17. The expanded clinical profile and the efficacy of colchicine therapy in Egyptian children suffering from familial mediterranean fever: a descriptive study.
  Talaat HS, Mohamed MF, El Rifai NM, Gomaa MA.Ital J Pediatr. 2012 Dec 4;38(1):66. [Epub ahead of print]
• 18. Interventions to improve symptoms and quality of life of patients with fibrotic interstitial lung disease: a systematic review of the literature.
  Bajwah S, Ross JR, Peacock JL, Higginson IJ, Wells AU, Patel AS, Koffman J, Riley J.Thorax. 2012 Dec 1. doi: 10.1136/thoraxjnl-2012-202040. [Epub ahead of print]
• 19. Elongation of in vitro cultured ovarian follicles in the mosquito, Culex pipiens pallens.
  Uchida K, Ichimura K.J Insect Physiol. 2012 Nov 29. doi:pii: S0022-1910(12)00230-2.  10.1016/j.jinsphys.2012.09.003. [Epub ahead of print]
• 20. Colchicine Protects Dopaminergic Neurons in a Rat Model of Parkinson’s Disease.
  Salama M, Ellaithy A, Helmy B, El-Gamal M, Tantawy D, Mohamed M, Sheashaa H, Sobh M, Arias-Carrión O.CNS Neurol Disord Drug Targets. 2012 Dec 3. [Epub ahead of print]

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