Botanical Ingredient

Diosmetin Safety Tips

Handling of Diosmetin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

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  Hu CQ, Yang XB, Yang XW, Liu JX.Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2571-5. Chinese.
• 2. Induction of melanogenesis by 4′-O-methylated flavonoids in B16F10 melanoma cells.
  Horibe I, Satoh Y, Shiota Y, Kumagai A, Horike N, Takemori H, Uesato S, Sugie S, Obata K, Kawahara H, Nagaoka Y.J Nat Med. 2012 Dec 4. [Epub ahead of print]
• 3. Novel Macrocyclic Monoterpene Glycosides from Bioactive Extract of Parkinsonia aculeata L.
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• 4. Pharmacokinetic study of luteolin, apigenin, chrysoeriol and diosmetin after oral administration of Flos Chrysanthemi extract in rats.
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• 5. On line characterization of 58 phenolic compounds in Citrus fruit juices from Spanish cultivars by high-performance liquid chromatography with photodiode-array detection coupled to electrospray ionization triple quadrupole mass spectrometry.
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• 6. HPLC-PDA-MS and NMR Characterization of a Hydroalcoholic Extract of  Citrus aurantium  L. var. amara Peel with Antiedematogenic Activity.
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• 7. [Chemical constituents from Gueldenstaedtia stenophylla].
  Wang G, Wang G, Lin B, Bai Y, Qin M.Zhongguo Zhong Yao Za Zhi. 2012 May;37(10):1412-6. Chinese.
• 8. Structure-activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells.
  Ninomiya M, Nishida K, Tanaka K, Watanabe K, Koketsu M.J Nat Med. 2012 Aug 2. [Epub ahead of print]
• 9. [Chemical constituents contained in seeds of Notopterygium franchetii].
  Zhang Y, Jiang S, Xu K, Shi H, Zhou Y, Deng W, Ding L, Peng S.Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):941-5. Chinese.
• 10. Bioactivity of Diosmetin Glycosides Isolated from the Epicarp of Date Fruits, Phoenix dactylifera, on the Biochemical Profile of Alloxan Diabetic Male Rats.
  Michael HN, Salib JY, Eskander EF.Phytother Res. 2012 Jul 4. doi: 10.1002/ptr.4777. [Epub ahead of print]
• 11. The flavonoids diosmetin and luteolin exert synergistic cytostatic effects in human hepatoma HepG2 cells via CYP1A-catalyzed metabolism, activation of JNK and ERK and P53/P21 up-regulation.
  Androutsopoulos VP, Spandidos DA.J Nutr Biochem. 2012 Jun 27. [Epub ahead of print]
• 12. [Compounds from fraction with cardiovascular activity of Chrysanthemum indicum].
  Sun Y, Ma X, Liu J.Zhongguo Zhong Yao Za Zhi. 2012 Jan;37(1):61-5. Chinese.
• 13. [Chemical constituents from stems of Lonicera macranthoides].
  Hu YF, Wu CC.Zhong Yao Cai. 2012 Jan;35(1):66-9. Chinese.
• 14. Simultaneous qualitative assessment and quantitative analysis of flavonoids in various tissues of lotus (Nelumbo nucifera) using high performance liquid chromatography coupled with triple quad mass spectrometry.
  Chen S, Fang L, Xi H, Guan L, Fang J, Liu Y, Wu B, Li S.Anal Chim Acta. 2012 Apr 29;724:127-35. doi: 10.1016/j.aca.2012.02.051. Epub 2012 Mar 10.
• 15. A new flavonol glycoside from Hylomecon vernalis.
  Lee SY, Kim KH, Lee IK, Lee KH, Choi SU, Lee KR.Arch Pharm Res. 2012 Mar;35(3):415-21. doi: 10.1007/s12272-012-0303-8. Epub 2012 Apr 5.
• 16. A profile of bioactive compounds of Rumex vesicarius L.
  El-Hawary SA, Sokkar NM, Ali ZY, Yehia MM.J Food Sci. 2011 Oct;76(8):C1195-202. doi: 10.1111/j.1750-3841.2011.02370.x.
• 17. Simultaneous determination and pharmacokinetic analysis of seven alkaloids and two flavonoids from rat plasma by HPLC-DAD after oral administration of Wuzhuyu decoction.
  Hu CQ, Li F, Yang XW.J Asian Nat Prod Res. 2012;14(4):370-81. doi: 10.1080/10286020.2012.656093.
• 18. Probing the binding of the flavonoid diosmetin to human serum albumin by multispectroscopic techniques.
  Zhang G, Wang L, Pan J.J Agric Food Chem. 2012 Mar 14;60(10):2721-9. doi: 10.1021/jf205260g. Epub 2012 Mar 6.
• 19. Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq.
  Wang BS, Huang GJ, Tai HM, Huang MH.Food Chem Toxicol. 2012 Mar;50(3-4):526-31. doi: 10.1016/j.fct.2011.12.010. Epub 2011 Dec 16.
• 20. A potent inhibitor of SIK2, 3, 3′, 7-trihydroxy-4′-methoxyflavon (4′-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.
  Kumagai A, Horike N, Satoh Y, Uebi T, Sasaki T, Itoh Y, Hirata Y, Uchio-Yamada K, Kitagawa K, Uesato S, Kawahara H, Takemori H, Nagaoka Y.PLoS One. 2011;6(10):e26148. doi: 10.1371/journal.pone.0026148. Epub 2011 Oct 13.