Botanical Ingredient

Ellagic Acid Safety Tips

Handling of Ellagic Acid should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Sustained deficit irrigation affects the colour and phytochemical characteristics of pomegranate juice.
  Mena P, Galindo A, Collado-González J, Ondoño S, García-Viguera C, Ferreres F, Torrecillas A, Gil-Izquierdo A.J Sci Food Agric. 2012 Nov 16. doi: 10.1002/jsfa.5991. [Epub ahead of print]
• 2. Inhibitory Effect of Ellagitannin Metabolites on IgE-Mediated Allergic Responses in RBL-2H3 Cells.
  Nagano T, Ito H, Okamoto T.Biosci Biotechnol Biochem. 2012 Dec 7. [Epub ahead of print]
• 3. Synthesis and Antitumor Activity of Ellagic Acid Peracetate.
  Ren Y, Wei M, Still PC, Yuan S, Deng Y, Chen X, Himmeldirk K, Kinghorn AD, Yu J.ACS Med Chem Lett. 2012 Aug 9;3(8):631-636. Epub 2012 Jun 17.
• 4. Characterization of Ellagitannins, Gallotannins, and Bound Proanthocyanidins from California Almond ( Prunus dulcis ) Varieties.
  Xie L, Roto AV, Bolling BW.J Agric Food Chem. 2012 Dec 12;60(49):12151-6. doi: 10.1021/jf303673r. Epub 2012 Dec 3.
• 5. Phenolic compounds in five Epilobium species collected from Estonia.
  Remmel I, Vares L, Toom L, Matto V, Raal A.Nat Prod Commun. 2012 Oct;7(10):1323-4.
• 6. Validated HPLC method for the simultaneous determination of taxol and ellagic acid in a Punica granatum fruit extract containing combination formulation.
  Vasudev SS, Ahmad FJ, Khar RK, Bhatnagar A, Kamal YT, Talegaonkar S, Iqbal Z.Pharmazie. 2012 Oct;67(10):834-8.
• 7. HPLC Determination of Phenolic Acids, Flavonoids and Juglone in Walnut Leaves.
  Nour V, Trandafir I, Cosmulescu S.J Chromatogr Sci. 2012 Nov 6. [Epub ahead of print]
• 8. Ellagic acid checks lymphoma promotion via regulation of PKC signaling pathway.
  Mishra S, Vinayak M.Mol Biol Rep. 2012 Oct 31. [Epub ahead of print]
• 9. Antibacterial, antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel methanolic extract.
  Fawole OA, Makunga NP, Opara UL.BMC Complement Altern Med. 2012 Oct 30;12:200. doi: 10.1186/1472-6882-12-200.
• 10. Composition of native Australian herbs polyphenolic-rich fractions and in vitro inhibitory activities against key enzymes relevant to metabolic syndrome.
  Sakulnarmrat K, Konczak I.Food Chem. 2012 Sep 15;134(2):1011-9. doi: 10.1016/j.foodchem.2012.02.217. Epub 2012 Mar 8.
• 11. Anthelmintic effect of plant extracts containing condensed and hydrolyzable tannins on Caenorhabditis elegans, and their antioxidant capacity.
  Katiki LM, Ferreira JF, Gonzalez JM, Zajac AM, Lindsay DS, Chagas AC, Amarante AF.Vet Parasitol. 2012 Oct 1. doi:pii: S0304-4017(12)00526-2.  10.1016/j.vetpar.2012.09.030. [Epub ahead of print]
• 12. Ellagic Acid: Cytodifferentiating and Antiproliferative Effects In Human Prostatic Cancer Cell Lines.
  Vanella L, Barbagallo I, Acquaviva R, Di Giacomo C, Cardile V, Abraham NG, Sorrenti V.Curr Pharm Des. 2012 Oct 18. [Epub ahead of print]
• 13. Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice.
  Dhingra D, Chhillar R.Pharmacol Rep. 2012 Jul;64(4):796-807.
• 14. Evaluation of antiulcer activity and mechanism of action of methanol stem bark extract of Lafoensia pacari A. St.-Hil. (Lytraceae) in experimental animals.
  Tamashiro Filho P, Sikiru Olaitan B, Tavares de Almeida DA, Lima JC, Marson-Ascêncio PG, Donizeti Ascêncio S, Rios-Santos F, Martins DT.J Ethnopharmacol. 2012 Dec 18;144(3):497-505. doi: 10.1016/j.jep.2012.09.019. Epub 2012 Oct 13.
• 15. Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis.
  Wang L, Ho J, Glackin C, Martins-Green M.Transl Oncol. 2012 Oct;5(5):344-55. Epub 2012 Oct 1.
• 16. Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer.
  Rocha A, Wang L, Penichet M, Martins-Green M.Breast Cancer Res Treat. 2012 Dec;136(3):647-58. doi: 10.1007/s10549-012-2264-5. Epub 2012 Oct 12.
• 17. Effects of ellagic acid on chemosensitivity to 5-fluorouracil in colorectal carcinoma cells.
  Kao TY, Chung YC, Hou YC, Tsai YW, Chen CH, Chang HP, Chou JL, Hsu CP.Anticancer Res. 2012 Oct;32(10):4413-8.
• 18. Ellagic acid inhibits cardiac arrhythmias, hypertrophy and hyperlipidaemia during myocardial infarction in rats.
  Kannan MM, Quine SD.Metabolism. 2013 Jan;62(1):52-61. doi: 10.1016/j.metabol.2012.06.003. Epub 2012 Oct 9.
• 19. Chemopreventive efficacy of Phyllanthus emblica L. (amla) fruit extract on 7,12-dimethylbenz(a)anthracene induced oral carcinogenesis – A dose-response study.
  Krishnaveni M, Mirunalini S.Environ Toxicol Pharmacol. 2012 Nov;34(3):801-10. doi: 10.1016/j.etap.2012.09.006. Epub 2012 Sep 24.
• 20. Textural Characteristic, Antioxidant Activity, Sugar, Organic Acid, and Phenolic Profiles of 10 Promising Jujube (Ziziphus jujuba Mill.) Selections.
  Gao QH, Wu CS, Yu JG, Wang M, Ma YJ, Li CL.J Food Sci. 2012 Nov;77(11):C1218-25. doi: 10.1111/j.1750-3841.2012.02946.x. Epub 2012 Oct 11.

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