Botanical Ingredient

Esculetin Safety Tips

Handling of Esculetin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Evaluation of Percutaneous Absorption of Esculetin: Effect of Chemical Enhancers.
  Del Rio Sancho S, Serna Jiménez CE, Calatayud Pascual MA, Balaguer Fernández C, Femenía Font A, Castillo García E, Merino V, López Castellano A.Planta Med. 2012 Dec 18. [Epub ahead of print]
• 2. Neuroprotective effects of umbelliferone and esculetin in a mouse model of Parkinson’s disease.
  Subramaniam SR, Ellis EM.J Neurosci Res. 2012 Nov 27. doi: 10.1002/jnr.23164. [Epub ahead of print]
• 3. Properties and analytical applications of the self-assembled complex {peroxidase-chitosan}.
  Veselova IA, Malinina LI, Rodionov PV, Shekhovtsova TN.Talanta. 2012 Dec 15;102:101-9. doi: 10.1016/j.talanta.2012.07.028. Epub 2012 Aug 18.
• 4. Novel Macrocyclic Monoterpene Glycosides from Bioactive Extract of Parkinsonia aculeata L.
  Marzouk MS, Moharram FA, El Dib RA, El-Hossary DG.Cell Biochem Biophys. 2012 Oct 23. [Epub ahead of print]
• 5. Protective effect of esculetin on hyperglycemia-mediated oxidative damage in the hepatic and renal tissues of experimental diabetic rats.
  Prabakaran D, Ashokkumar N.Biochimie. 2012 Oct 16. doi:pii: S0300-9084(12)00408-7.  10.1016/j.biochi.2012.10.008. [Epub ahead of print]
• 6. Simultaneous determination of esculin and its metabolite esculetin in rat plasma by LC-ESI-MS/MS and its application in pharmacokinetic study.
  Li YY, Song YY, Liu CH, Huang XT, Zheng X, Li N, Xu ML, Mi SQ, Wang NS.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 15;907:27-33. doi: 10.1016/j.jchromb.2012.08.027. Epub 2012 Sep 7.
• 7. Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation.
  Jung HA, Park JJ, Islam MN, Jin SE, Min BS, Lee JH, Sohn HS, Choi JS.Arch Pharm Res. 2012 Jun;35(6):1021-35. doi: 10.1007/s12272-012-0610-0. Epub 2012 Jun 30.
• 8. [Chemical constituents from Gueldenstaedtia stenophylla].
  Wang G, Wang G, Lin B, Bai Y, Qin M.Zhongguo Zhong Yao Za Zhi. 2012 May;37(10):1412-6. Chinese.
• 9. Evaluation of the antioxidant capacity of synthesized coumarins.
  Vianna DR, Bubols G, Meirelles G, Silva BV, da Rocha A, Lanznaster M, Monserrat JM, Garcia SC, von Poser G, Eifler-Lima VL.Int J Mol Sci. 2012;13(6):7260-70. doi: 10.3390/ijms13067260. Epub 2012 Jun 13.
• 10. [Antioxidant activity of hydroxy derivatives of coumarin].
  Potapovich MV, Metelitsa DI, Shadyro OI.Prikl Biokhim Mikrobiol. 2012 May-Jun;48(3):282-8. Russian.
• 11. Biosynthesis of coumarin glycosides by transgenic hairy roots of Polygonum multiflorum.
  Zhou L, Tian T, Xue B, Song L, Liu L, Yu R.Biosci Biotechnol Biochem. 2012;76(5):1008-10. Epub 2012 May 7.
• 12. Esculetin promotes type I procollagen expression in human dermal fibroblasts through MAPK and PI3K/Akt pathways.
  Park JH, Kim SR, An HJ, Kim WJ, Choe M, Han JA.Mol Cell Biochem. 2012 Sep;368(1-2):61-7. doi: 10.1007/s11010-012-1342-7. Epub 2012 May 13.
• 13. Drought stress has contrasting effects on antioxidant enzymes activity and phenylpropanoid biosynthesis in Fraxinus ornus leaves: an excess light stress affair?
  Fini A, Guidi L, Ferrini F, Brunetti C, Di Ferdinando M, Biricolti S, Pollastri S, Calamai L, Tattini M.J Plant Physiol. 2012 Jul 1;169(10):929-39. doi: 10.1016/j.jplph.2012.02.014. Epub 2012 Apr 24.
• 14. Collagenase inhibitors from Viola yedoensis.
  Oshima N, Narukawa Y, Takeda T, Kiuchi F.J Nat Med. 2013 Jan;67(1):240-5. doi: 10.1007/s11418-012-0665-8. Epub 2012 Apr 13.
• 15. A natural coumarin derivative esculetin offers neuroprotection on cerebral ischemia/reperfusion injury in mice.
  Wang C, Pei A, Chen J, Yu H, Sun ML, Liu CF, Xu X.J Neurochem. 2012 Jun;121(6):1007-13. doi: 10.1111/j.1471-4159.2012.07744.x.
• 16. Determination of the esculetin contents of medicinal plants by liquid chromatography-tandem mass spectrometry.
  Yun ES, Park SK, Kim BS, Chae YZ, Cho SM, Yi H, Cho HJ, Shin HC.Biomed Chromatogr. 2012 Oct;26(10):1247-51. doi: 10.1002/bmc.2686. Epub 2012 Mar 1.
• 17. Hepatoprotective activity of Cyperus alternifolius on carbon tetrachloride-induced hepatotoxicity in rats.
  Awaad AS, Soliman GA, El-Sayed DF, El-Gindi OD, Alqasoumi SI.Pharm Biol. 2012 Feb;50(2):155-61. doi: 10.3109/13880209.2011.580351.
• 18. New biological activities of Casimiroa edulis leaf extract and isolated compounds.
  Awaad AS, Al-Jaber NA, Soliman GA, Al-Outhman MR, Zain ME, Moses JE, El-Meligy RM.Phytother Res. 2012 Mar;26(3):452-7. doi: 10.1002/ptr.3690. Epub 2011 Dec 15.
• 19. Esculetin inhibits N-methyl-D-aspartate neurotoxicity via glutathione preservation in primary cortical cultures.
  Lee CR, Shin EJ, Kim HC, Choi YS, Shin T, Wie MB.Lab Anim Res. 2011 Sep;27(3):259-63. doi: 10.5625/lar.2011.27.3.259. Epub 2011 Sep 30.
• 20. Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents.
  Kwon OS, Choi JS, Islam MN, Kim YS, Kim HP.Arch Pharm Res. 2011 Sep;34(9):1561-9. doi: 10.1007/s12272-011-0919-0. Epub 2011 Oct 6.