Botanical Ingredient

Evodiamine Safety Tips

Handling of Evodiamine should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Topoisomerase I Inhibitor Evodiamine Acts As an Antibacterial Agent against Drug-Resistant Klebsiella pneumoniae.
  Wu JY, Chang MC, Chen CS, Lin HC, Tsai HP, Yang CC, Yang CH, Lin CM.Planta Med. 2012 Nov 16. [Epub ahead of print]
• 2. Evodiamine activates autophagy as a cytoprotective response in murine             Lewis lung carcinoma cells.
  Tu YJ, Fan X, Yang X, Zhang C, Liang HP.Oncol Rep. 2013 Feb;29(2):481-90. doi: 10.3892/or.2012.2125. Epub 2012 Nov 6.
• 3. Effect of novel synthetic evodiamine analogue on sexual behavior in male rats.
  Vyawahare NS, Hadambar AA, Chothe AS, Jalnapurkar RR, Bhandare AM, Kathiravan MK.J Chem Biol. 2012 Jan;5(1):35-42. doi: 10.1007/s12154-011-0067-5. Epub 2011 Oct 4.
• 4. Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells.
  Yang J, Cai X, Lu W, Hu C, Xu X, Yu Q, Cao P.Cancer Lett. 2013 Jan 28;328(2):243-51. doi: 10.1016/j.canlet.2012.09.019. Epub 2012 Sep 29.
• 5. Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis.
  Wei J, Ching LC, Zhao JF, Shyue SK, Lee HF, Kou YR, Lee TS.Acta Physiol (Oxf). 2012 Oct 1. doi: 10.1111/apha.12005. [Epub ahead of print]
• 6. Alkaloids isolated from natural herbs as the anticancer agents.
  Lu JJ, Bao JL, Chen XP, Huang M, Wang YT.Evid Based Complement Alternat Med. 2012;2012:485042. doi: 10.1155/2012/485042. Epub 2012 Sep 4.
• 7. Variations in the composition of Fructus Evodiae after processing with Radix Glycyrrhizae extract.
  Xiao BY, Mao SJ, Li XD.Chin J Integr Med. 2012 Oct;18(10):782-7. doi: 10.1007/s11655-012-1178-8. Epub 2012 Sep 11.
• 8. Binding Mode Prediction of Evodiamine within Vanilloid Receptor TRPV1.
  Wang Z, Sun L, Yu H, Zhang Y, Gong W, Jin H, Zhang L, Liang H.Int J Mol Sci. 2012;13(7):8958-69. doi: 10.3390/ijms13078958. Epub 2012 Jul 18.
• 9. A drug screening method based on the autophagy pathway and studies of the mechanism of evodiamine against influenza A virus.
  Dai JP, Li WZ, Zhao XF, Wang GF, Yang JC, Zhang L, Chen XX, Xu YX, Li KS.PLoS One. 2012;7(8):e42706. doi: 10.1371/journal.pone.0042706. Epub 2012 Aug 10.
• 10. New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations.
  Dong G, Wang S, Miao Z, Yao J, Zhang Y, Guo Z, Zhang W, Sheng C.J Med Chem. 2012 Sep 13;55(17):7593-613. doi: 10.1021/jm300605m. Epub 2012 Aug 22.
• 11. Investigation of the in Vitro Metabolism of Evodiamine: Characterization of Metabolites and Involved Cytochrome P450 Isoforms.
  Sun HZ, Fang ZZ, Cao YF, Sun XY, Hong M.Phytother Res. 2012 Jul 5. doi: 10.1002/ptr.4766. [Epub ahead of print]
• 12. In vitro cellular uptake of evodiamine and rutaecarpine using a microemulsion.
  Zhang YT, Huang ZB, Zhang SJ, Zhao JH, Wang Z, Liu Y, Feng NP.Int J Nanomedicine. 2012;7:2465-72. doi: 10.2147/IJN.S30616. Epub 2012 May 18.
• 13. New glycosidic alkaloid from the nearly ripe fruits of Euodia rutaecarpa.
  Hu CQ, Li KK, Yang XW.J Asian Nat Prod Res. 2012;14(7):634-9. doi: 10.1080/10286020.2012.682154. Epub 2012 May 15.
• 14. Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo.
  Chen F, Li S, Li D, Ding JS.Fitoterapia. 2012 Jul;83(5):954-60. doi: 10.1016/j.fitote.2012.04.021. Epub 2012 Apr 29.
• 15. Standardless (1) H NMR determination of pharmacologically active substances in dietary supplements and medicines that have been illegally traded over the Internet.
  Monakhova YB, Kuballa T, Löbell-Behrends S, Maixner S, Kohl-Himmelseher M, Ruge W, Lachenmeier DW.Drug Test Anal. 2012 May 1. doi: 10.1002/dta.1367. [Epub ahead of print]
• 16. Mosquito larvicidal activity of alkaloids and limonoids derived from Evodia rutaecarpa unripe fruits against Aedes albopictus (Diptera: Culicidae).
  Liu ZL, Liu QZ, Du SS, Deng ZW.Parasitol Res. 2012 Sep;111(3):991-6. doi: 10.1007/s00436-012-2923-9. Epub 2012 Apr 25.
• 17. Simultaneous determination of six alkaloids and one monoterpene in rat plasma by liquid chromatography-tandem mass spectrometry and pharmacokinetic study after oral administration of a Chinese medicine Wuji Pill.
  Yuan J, Wang Y, An R, Wang S, Li SJ, Jia JY, Bligh SW, Wang XH, Ma YM.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 1;895-896:154-61. doi: 10.1016/j.jchromb.2012.03.036. Epub 2012 Apr 1.
• 18. Preparation of evodiamine solid dispersions and its pharmacokinetics.
  Xu H, Zhang T, Yang H, Xiao X, Bian Y, Si D, Liu C.Indian J Pharm Sci. 2011 May;73(3):276-81. doi: 10.4103/0250-474X.93511.
• 19. Design and evaluation of a novel evodiamine-phospholipid complex for improved oral bioavailability.
  Tan Q, Liu S, Chen X, Wu M, Wang H, Yin H, He D, Xiong H, Zhang J.AAPS PharmSciTech. 2012 Jun;13(2):534-47. doi: 10.1208/s12249-012-9772-9. Epub 2012 Mar 28.
• 20. Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase.
  Ching LC, Chen CY, Su KH, Hou HH, Shyue SK, Kou YR, Lee TS.Mol Med. 2012 Mar 21. doi: 10.2119/molmed.2011.00461. [Epub ahead of print]

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