Botanical Ingredient

Gastrodin Safety Tips

Handling of Gastrodin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. [Effect and mechanism of gastrodin in relaxing isolated thoracic aorta rings in rats].
  Zhang Y, Yu T, Xu J, Bian X, Xu J, Liu Y.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(14):2135-8. Chinese.
• 2. [Chemical constituents from aqueous extract of Gastrodia elata].
  Wang Y, Lin S, Chen M, Jiang B, Guo Q, Zhu C, Wang S, Yang Y, Shi J.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1775-81. Chinese.
• 3. Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway.
  Zhao X, Zou Y, Xu H, Fan L, Guo H, Li X, Li G, Zhang X, Dong M.Brain Res. 2012 Oct 30;1482:13-21. doi: 10.1016/j.brainres.2012.09.010. Epub 2012 Sep 13.
• 4. Gastrodin inhibits cell proliferation in vascular smooth muscle cells             and attenuates neointima formation in vivo.
  Zhu L, Guan H, Cui C, Tian S, Yang D, Wang X, Zhang S, Wang L, Jiang H.Int J Mol Med. 2012 Nov;30(5):1034-40. doi: 10.3892/ijmm.2012.1100. Epub 2012 Aug 20.
• 5. Gastrodin improved baroreflex sensitivity and increased gamma-amino butyric acid content in brains without decreasing blood pressure in spontaneously hypertensive rats.
  Liu W, Su BL, Wang ZS, Zhang X, Gao YS, Song SW.CNS Neurosci Ther. 2012 Oct;18(10):873-5. doi: 10.1111/j.1755-5949.2012.00381.x. Epub 2012 Aug 20. No abstract available.
• 6. Gastrodin inhibits allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing excitability of nociceptive primary sensory neurons.
  Sun W, Miao B, Wang XC, Duan JH, Ye X, Han WJ, Wang WT, Luo C, Hu SJ.PLoS One. 2012;7(6):e39647. doi: 10.1371/journal.pone.0039647. Epub 2012 Jun 25.
• 7. [The pharmacological mechanism of gastrodin on calcitonin gene-related peptide of cultured rat trigeminal ganglion].
  Luo GG, Fan WJ, Yuan XY, Yuan BB, Lü SM, Cao YX, Xu CB.Yao Xue Xue Bao. 2011 Dec;46(12):1451-6. Chinese.
• 8. Identification of three novel polyphenolic compounds, origanine A-C, with unique skeleton from Origanum vulgare L. using the hyphenated LC-DAD-SPE-NMR/MS methods.
  Liu H, Zheng A, Liu H, Yu H, Wu X, Xiao C, Dai H, Hao F, Zhang L, Wang Y, Tang H.J Agric Food Chem. 2012 Jan 11;60(1):129-35. doi: 10.1021/jf204406u. Epub 2011 Dec 29.
• 9. Formulation and evaluation of in situ gelling systems for intranasal administration of gastrodin.
  Cai Z, Song X, Sun F, Yang Z, Hou S, Liu Z.AAPS PharmSciTech. 2011 Dec;12(4):1102-9. doi: 10.1208/s12249-011-9678-y. Epub 2011 Aug 31.
• 10. [UPLC-MS analysis of constituents of dachuanxiong fang active parts absorbed into blood].
  Wei Y, Lin X, Zhang N, Feng Y.Zhongguo Zhong Yao Za Zhi. 2011 May;36(9):1245-8. Chinese.
• 11. [In vivo transmigration of active ingredients from Gastrodia elata in dachuanxiong fang].
  Lin X, Yuan Y, Hong Y, Xu D, Shen L, Feng Y.Zhongguo Zhong Yao Za Zhi. 2011 May;36(9):1175-8. Chinese.
• 12. Gastrodin protects against cardiac hypertrophy and fibrosis.
  Shu C, Chen C, Zhang DP, Guo H, Zhou H, Zong J, Bian Z, Dong X, Dai J, Zhang Y, Tang Q.Mol Cell Biochem. 2012 Jan;359(1-2):9-16. doi: 10.1007/s11010-011-0992-1. Epub 2011 Jul 16.
• 13. Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways.
  Dai JN, Zong Y, Zhong LM, Li YM, Zhang W, Bian LG, Ai QL, Liu YD, Sun J, Lu D.PLoS One. 2011;6(7):e21891. doi: 10.1371/journal.pone.0021891. Epub 2011 Jul 12.
• 14. [Simultaneous determination of four active compounds in tiangou capsules by HPLC].
  Wang X, Li L, Dai L.Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(7):868-70. Chinese.
• 15. Pharmacokinetics comparative study of a novel Chinese traditional herbal formula and its compatibility.
  Zheng Q, Yue PF, Wu B, Hu PY, Wu ZF, Yang M.J Ethnopharmacol. 2011 Sep 1;137(1):221-5. doi: 10.1016/j.jep.2011.05.007. Epub 2011 May 13.
• 16. [Pharmacokinetics of gastrodin from compound Tianma granule in rats].
  Yang Y, Han FM, Du P, Chen Y.Yao Xue Xue Bao. 2010 Apr;45(4):484-8. Chinese.
• 17. Inhibitors of microglial neurotoxicity: focus on natural products.
  Choi DK, Koppula S, Suk K.Molecules. 2011 Jan 25;16(2):1021-43. doi: 10.3390/molecules16021021. Review.
• 18. The transport of gastrodin in Caco-2 cells and uptake in Bcap37 and Bcap37/MDR1 cells.
  Wang XD, Zeng S.Yao Xue Xue Bao. 2010 Dec;45(12):1497-502.
• 19. Preventive effect of gastrodin on cognitive decline after cardiac surgery with cardiopulmonary bypass: a double-blind, randomized controlled study.
  Zhang Z, Ma P, Xu Y, Zhan M, Zhang Y, Yao S, Zhang S.J Huazhong Univ Sci Technolog Med Sci. 2011 Feb;31(1):120-7. doi: 10.1007/s11596-011-0162-4. Epub 2011 Feb 19.
• 20. [Constituents of Gymnadenia conopsea].
  Yue Z, Zi J, Zhu C, Lin S, Yang Y, Shi J.Zhongguo Zhong Yao Za Zhi. 2010 Nov;35(21):2852-61. Chinese.

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