Botanical Ingredient

Genistein Safety Tips

Handling of Genistein should only be performed by personnel trained and familiar with the handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. [[Gly14]-humanin protects against Aβ(31-35)-induced impairment of spatial learning and memory in rats].
  Yuan L, Han WN, Li SF, Liu XJ, Wu MN, Qi JS.Sheng Li Xue Bao. 2012 Dec 25;64(6):625-32. Chinese.
• 2. Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells.
  Zhai X, Lin M, Zhang F, Hu Y, Xu X, Li Y, Liu K, Ma X, Tian X, Yao J.Mol Nutr Food Res. 2012 Dec 15. doi: 10.1002/mnfr.201200536. [Epub ahead of print]
• 3. Phytoestrogen Genistein Protects Against Endothelial Barrier Dysfunction in Vascular Endothelial Cells Through PKA-Mediated Suppression of RhoA Signaling.
  Jia Z, Zhen W, Velayutham Anandh Babu P, Liu D.Endocrinology. 2012 Dec 18. [Epub ahead of print]
• 4. Homocysteine, heat shock proteins, genistein and vitamins in ischemic stroke – pathogenic and therapeutic implications.
  Banecka-Majkutewicz Z, Sawu?a W, Kadzinski L, W?grzyn A, Banecki B.Acta Biochim Pol. 2012 Dec 19. [Epub ahead of print]
• 5. Probing the binding sites of resveratrol, genistein, and curcumin with milk β-lactoglobulin.
  Kanakis CD, Tarantilis PA, Polissiou MG, Tajmir-Riahi HA.J Biomol Struct Dyn. 2012 Dec 19. [Epub ahead of print]
• 6. LC-MS/MS determination of nevadensin in rat plasma and its application in pharmacokinetic studies.
  Liu H, Yan C, Li C, Lin L.J Pharm Biomed Anal. 2013 Feb 23;74:56-61. doi: 10.1016/j.jpba.2012.10.021. Epub 2012 Nov 1.
• 7. 123 genistein transport across the bovine oviduct epithelium.
  Simintiras C, Courts FL, Sturmey RG.Reprod Fertil Dev. 2012 Dec;25(1):208-9. doi: 10.1071/RDv25n1Ab123.
• 8. Cytokine Modulation is Necessary for Efficacious Treatment of Experimental Neuropathic Pain.
  Sacerdote P, Franchi S, Moretti S, Castelli M, Procacci P, Magnaghi V, Panerai AE.J Neuroimmune Pharmacol. 2012 Dec 16. [Epub ahead of print]
• 9. Simultaneous monitoring of seven phenolic metabolites of endocrine disrupting compounds (EDC) in human urine using gas chromatography with tandem mass spectrometry.
  Schmidt L, Müller J, Göen T.Anal Bioanal Chem. 2012 Dec 16. [Epub ahead of print]
• 10. The influence of common metal ions on the interactions of the isoflavone genistein with bovine serum albumin.
  Singha Roy A, Tripathy DR, Chatterjee A, Dasgupta S.Spectrochim Acta A Mol Biomol Spectrosc. 2012 Sep 28;102C:393-402. doi: 10.1016/j.saa.2012.09.053. [Epub ahead of print]
• 11. Mitigation of Radiation-Induced Lung Injury with EUK-207 and Genistein: Effects in Adolescent Rats.
  Mahmood J, Jelveh S, Zaidi A, Doctrow SR, Hill RP.Radiat Res. 2012 Dec 13. [Epub ahead of print]
• 12. Genistein, a soy phytoestrogen, prevents the growth of BG-1 ovarian cancer cells induced by 17β-estradiol or bisphenol A via the inhibition of cell cycle progression.
  Hwang KA, Kang NH, Yi BR, Lee HR, Park MA, Choi KC.Int J Oncol. 2012 Nov 29. doi: 10.3892/ijo.2012.1719. [Epub ahead of print]
• 13. MAP-kinase activity in etiolated Cucumis sativus cotyledons: The effect of red and far-red light irradiation.
  Alvarez-Flórez F, Vidal D, Simón E.Plant Physiol Biochem. 2012 Nov 23;63C:1-7. doi: 10.1016/j.plaphy.2012.11.008. [Epub ahead of print]
• 14. Anti-breast cancer potential of daidzein in rodents.
  Liu X, Suzuki N, Santosh Laxmi YR, Okamoto Y, Shibutani S.Life Sci. 2012 Oct 5;91(11-12):415-9.
• 15. Genistein attenuates vascular endothelial impairment in ovariectomized hyperhomocysteinemic rats.
  Zhen P, Zhao Q, Hou D, Liu T, Jiang D, Duan J, Lu L, Wang W.J Biomed Biotechnol. 2012;2012:730462. doi: 10.1155/2012/730462. Epub 2012 Nov 6.
• 16. Tumor necrosis factor α stimulates expression and secretion of urokinase plasminogen activator in human dental pulp cells.
  Narita T, Muromachi K, Kamio N, Nakao S, Matsushima K, Hashizume H.J Oral Sci. 2012;54(4):329-36.
• 17. Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth.
  Gaete L, Tchernitchin AN, Bustamante R, Villena J, Lemus I, Gidekel M, Cabrera G, Astorga P.J Med Food. 2012 Dec;15(12):1081-90. doi: 10.1089/jmf.2011.0322. Epub 2012 Dec 10.
• 18. A comparative analysis of the photo-protective effects of soy isoflavones in their aglycone and glucoside forms.
  Iovine B, Iannella ML, Gasparri F, Giannini V, Monfrecola G, Bevilacqua MA.Int J Mol Sci. 2012 Dec 4;13(12):16444-56. doi: 10.3390/ijms131216444.
• 19. Antifeedant activity of luteolin and genistein against the pea aphid, Acyrthosiphon pisum.
  Go?awska S, Lukasik I.J Pest Sci (2004). 2012 Dec;85(4):443-450. Epub 2012 Jun 22.
• 20. Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity — a role of immunomodulation in chemoprevention.
  Chen SS, Corteling R, Stevanato L, Sinden J.Discov Med. 2012 Nov;14(78):327-33.

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