Botanical Ingredient

Glycyrrhizic Acid Safety Tips

Handling of Glycyrrhizic Acid should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Modulation of genotoxicity of oxidative mutagens by glycyrrhizic acid from Glycyrrhiza glabra L.
  Kaur P, Sharma N, Singh B, Kumar S, Kaur S.Pharmacognosy Res. 2012 Oct;4(4):189-95. doi: 10.4103/0974-8490.102260.
• 2. Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation.
  Kao TC, Wu CH, Yen GC.Phytomedicine. 2012 Dec 3. doi:pii: S0944-7113(12)00379-0.  10.1016/j.phymed.2012.10.013. [Epub ahead of print]
• 3. Glycyrrhetinic Acid Exhibits Strong Inhibitory Effects Towards UDP-Glucuronosyltransferase (UGT) 1A3 and 2B7.
  Huang YP, Cao YF, Fang ZZ, Zhang YY, Hu CM, Sun XY, Yu ZW, Zhu X, Hong M, Yang L, Sun HZ.Phytother Res. 2012 Nov 12. doi: 10.1002/ptr.4875. [Epub ahead of print]
• 4. Comparative Analysis of the Main Bioactive Components of San-ao Decoction and Its Series of Formulations.
  Shu X, Tang Y, Jiang C, Shang E, Fan X, Ding A.Molecules. 2012 Nov 1;17(11):12925-37. doi: 10.3390/molecules171112925.
• 5. [Study on effects of kurarinol combined with glycyrrhizic acid on cellular immunity of patients with chronic hepatitis B].
  Gu XB, Yang XJ, Jiang XH, Hua Z, Lu ZH, Zhang B, Zhu YF, Wu HY, Jiang YM, Chen HK, Pei H, Zhou YL.Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012 Apr;26(2):108-10. Chinese.
• 6. [Study on in vitro and in vivo material base of Sini San by UPLC-PDA-MS/MS].
  Qiao Y, Wen J, Song Y, Lu X, Xiong Z, Li F.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1672-6. Chinese.
• 7. Chromolithic method development, validation and system suitability analysis of ultra-sound assisted extraction of glycyrrhizic acid and glycyrrhetinic acid from Glycyrrhiza glabra.
  Gupta S, Sharma R, Pandotra P, Jaglan S, Gupta AP.Nat Prod Commun. 2012 Aug;7(8):991-4.
• 8. Studies on silver nanoparticle-glycyrrhizic Acid complex as a radioprotector and an adjuvant in radiotherapy under in vivo conditions.
  Chandrasekharan DK, Nair CK.Cancer Biother Radiopharm. 2012 Dec;27(10):642-51. doi: 10.1089/cbr.2012.1286. Epub 2012 Sep 13.
• 9. Glycyrrhizic acid induces apoptosis in WEHI-3 mouse leukemia cells through             the caspase- and mitochondria-dependent pathways.
  Chueh FS, Hsiao YT, Chang SJ, Wu PP, Yang JS, Lin JJ, Chung JG, Lai TY.Oncol Rep. 2012 Dec;28(6):2069-76. doi: 10.3892/or.2012.2029. Epub 2012 Sep 12.
• 10. Variations in the composition of Fructus Evodiae after processing with Radix Glycyrrhizae extract.
  Xiao BY, Mao SJ, Li XD.Chin J Integr Med. 2012 Oct;18(10):782-7. doi: 10.1007/s11655-012-1178-8. Epub 2012 Sep 11.
• 11. Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry.
  Qiao X, Ye M, Xiang C, Wang Q, Liu CF, Miao WJ, Guo DA.J Chromatogr A. 2012 Oct 5;1258:84-93. doi: 10.1016/j.chroma.2012.08.041. Epub 2012 Aug 17.
• 12. The role of Glycyrrhizin, an inhibitor of HMGB1 protein, in anticancer therapy.
  Smolarczyk R, Cichon T, Matuszczak S, Mitrus I, Lesiak M, Kobusinska M, Kamysz W, Jarosz M, Sieron A, Szala S.Arch Immunol Ther Exp (Warsz). 2012 Oct;60(5):391-9. doi: 10.1007/s00005-012-0183-0. Epub 2012 Aug 25.
• 13. [Effect of a combination of glutamyl-tryptophan and glycyrrhizic acid on the course of acute infection caused by influenza (H3H2) virus in mice].
  Smirnov VS, Zarubaev VV, Anfimov PM, Shtro AA.Vopr Virusol. 2012 May-Jun;57(3):23-7. Russian.
• 14. The Anti-Angiogenic Activities of Glycyrrhizic Acid in Tumor Progression.
  Kim KJ, Choi JS, Kim KW, Jeong JW.Phytother Res. 2012 Aug 16. doi: 10.1002/ptr.4800. [Epub ahead of print]
• 15. [Preliminary study in glycyrrhizin content and its influencing factors of wild and cultivated in different region of China].
  Wei S, Wang W, Wang J, Sun Z, Liu C, Wang H, Yang Z, Wu B.Zhongguo Zhong Yao Za Zhi. 2012 May;37(10):1341-5. Chinese.
• 16. A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata.
  Yang DQ, You LP, Song PH, Zhang LX, Bai YP.Chin J Integr Med. 2012 Aug;18(8):621-5. doi: 10.1007/s11655-012-1173-0. Epub 2012 Aug 2.
• 17. Glycyrrhizin-modified O-carboxymethyl chitosan nanoparticles as drug vehicles targeting hepatocellular carcinoma.
  Shi L, Tang C, Yin C.Biomaterials. 2012 Oct;33(30):7594-604. doi: 10.1016/j.biomaterials.2012.06.072. Epub 2012 Jul 13.
• 18. Glycyrrhizin in patients who failed previous interferon alpha-based therapies: biochemical and histological effects after 52 weeks.
  Manns MP, Wedemeyer H, Singer A, Khomutjanskaja N, Dienes HP, Roskams T, Goldin R, Hehnke U, Inoue H; European SNMC Study Group.J Viral Hepat. 2012 Aug;19(8):537-46. doi: 10.1111/j.1365-2893.2011.01579.x. Epub 2012 Feb 24.
• 19. [Effect of 18alpha-glycyrrhizic acid and 18beta-glycyrrhizic acid on P-gp function and expression in Caco-2 cells].
  Yan M, Li L, Li H, Fang P, Xu P, Zheng M, Xu D.Zhongguo Zhong Yao Za Zhi. 2012 Jan;37(1):99-103. Chinese.
• 20. Improvement of oral bioavailability of glycyrrhizin by sodium deoxycholate/phospholipid-mixed nanomicelles.
  Jin S, Fu S, Han J, Jin S, Lv Q, Lu Y, Qi J, Wu W, Yuan H.J Drug Target. 2012 Aug;20(7):615-22. doi: 10.3109/1061186X.2012.702770. Epub 2012 Jun 23.

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