Botanical Ingredient

Hesperidin Safety Tips

Handling of Hesperidin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

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• 4. Molecular spectroscopic on interaction between Methyl hesperidin and Buman serum albumin.
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• 7. Kappa-opioid receptors mediate the antidepressant-like activity of hesperidin in the mouse forced swimming test.
  Filho CB, Fabbro LD, de Gomes MG, Goes AT, Souza LC, Boeira SP, Jesse CR.Eur J Pharmacol. 2012 Nov 20. doi:pii: S0014-2999(12)00934-X.  10.1016/j.ejphar.2012.11.003. [Epub ahead of print]
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• 11. Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats.
  Shi X, Liao S, Mi H, Guo C, Qi D, Li F, Zhang C, Yang Z.Molecules. 2012 Nov 1;17(11):12868-81. doi: 10.3390/molecules171112868.
• 12. Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability.
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• 13. Hesperidin-3′-o-methylether is more potent than hesperidin in phosphodiesterase inhibition and suppression of ovalbumin-induced airway hyperresponsiveness.
  Yang YL, Hsu HT, Wang KH, Wang CS, Chen CM, Ko WC.Evid Based Complement Alternat Med. 2012;2012:908562. doi: 10.1155/2012/908562. Epub 2012 Oct 3.
• 14. Synthesis and anti-hyperglycemic activity of hesperidin derivatives.
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  Souza LC, de Gomes MG, Goes AT, Del Fabbro L, Filho CB, Boeira SP, Jesse CR.Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:103-9. doi: 10.1016/j.pnpbp.2012.09.003. Epub 2012 Sep 17.
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  Qiao Y, Wen J, Song Y, Lu X, Xiong Z, Li F.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1672-6. Chinese.
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