Botanical Ingredient

Icariin Safety Tips

Handling of Icariin should only be performed by personnel trained and familiar with the handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Effects and interaction of icariin, curculigoside, and berberine in er-xian decoction, a traditional chinese medicinal formula, on osteoclastic bone resorption.
  Xue L, Jiao L, Wang Y, Nie Y, Han T, Jiang Y, Rahman K, Zhang Q, Qin L.Evid Based Complement Alternat Med. 2012;2012:490843. doi: 10.1155/2012/490843. Epub 2012 Nov 1.
• 2. [Screening of bioactive components in epimedium for osteoporosis treatment by model population analysis].
  Yang QX, Liu YQ, Wang L, Xiao HB.Yao Xue Xue Bao. 2012 Sep;47(9):1205-9. Chinese.
• 3. [Inhibitory effect of icariin on acetylcholinesterase].
  Zhang YD, Cai YN, Zhang Q, Qi ZL, Gao QQ.Yao Xue Xue Bao. 2012 Sep;47(9):1141-6. Chinese.
• 4. Comparative effects of er-xian decoction, epimedium herbs, and icariin with estrogen on bone and reproductive tissue in ovariectomized rats.
  Xue L, Wang Y, Jiang Y, Han T, Nie Y, Zhao L, Zhang Q, Qin L.Evid Based Complement Alternat Med. 2012;2012:241416. doi: 10.1155/2012/241416. Epub 2012 Nov 7.
• 5. [Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro].
  Mao XY, Bian Q, Shen ZY.Zhong Xi Yi Jie He Xue Bao. 2012 Nov;10(11):1272-8. Chinese.
• 6. Variation of Medicinal Components in a Unique Geographical Accession of Horny Goat Weed Epimedium sagittatum Maxim. (Berberidaceae).
  Liang Q, Wei G, Chen J, Wang Y, Huang H.Molecules. 2012 Nov 8;17(11):13345-56. doi: 10.3390/molecules171113345.
• 7. Icariin stimulates the proliferation of rat Sertoli cells in an ERK1/2-dependent manner in vitro.
  Nan Y, Zhang X, Yang G, Xie J, Lu Z, Wang W, Ni X, Cao X, Ma J, Wang Z.Andrologia. 2012 Nov 7. doi: 10.1111/and.12035. [Epub ahead of print]
• 8. [Effect of icariin on learning and memory abilities and activity of cholinergic system of senescence-accelerated mice SAMP10].
  Gao L, Tang Q, He X, Bi M.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(14):2117-21. Chinese.
• 9. Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases.
  Cao YF, He RR, Cao J, Chen JX, Huang T, Liu Y.Evid Based Complement Alternat Med. 2012;2012:395912. doi: 10.1155/2012/395912. Epub 2012 Oct 16.
• 10. Enhancement of epimedium fried with suet oil based on in vivo formation of self-assembled flavonoid compound nanomicelles.
  Cui L, Sun E, Zhang ZH, Tan XB, Wei YJ, Jin X, Jia XB.Molecules. 2012 Nov 1;17(11):12984-96. doi: 10.3390/molecules171112984.
• 11. Immunoadjuvant activity of icariin that induces Th1-type antibody in mice.
  Rhew KY, Han Y.Arch Pharm Res. 2012 Sep;35(9):1685-91. doi: 10.1007/s12272-012-0920-2. Epub 2012 Oct 9.
• 12. [Variation of icariin and total flavonoid of Epimedium acuminatum in different parts and habitats].
  Zhou T, Zhang X, Guo L, Lin G, Jiang W, Ai Q, Zhang C.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):1917-21. Chinese.
• 13. Maohuoside A Acts in a BMP-dependent Manner during Osteogenesis.
  Cai M, Li G, Tao K, Yang Y, Lou L, Cai Z, Yu Y.Phytother Res. 2012 Sep 25. doi: 10.1002/ptr.4840. [Epub ahead of print]
• 14. [Comparison of effects of kaempferide and anhydroicaritin on biomineralization of cultured osteoblasts].
  Song P, Yao J, Ma HP, Ge BF, Chen KM, Guo XY, Lü X.Yao Xue Xue Bao. 2012 Jul;47(7):890-6. Chinese.
• 15. Epimedium koreanum Extract and Its Constituent Icariin Improve Motor Dysfunction in Spinal Cord Injury.
  Tohda C, Nagata A.Evid Based Complement Alternat Med. 2012;2012:731208. doi: 10.1155/2012/731208. Epub 2012 Aug 23.
• 16. [Phenotype-based primary screening for drugs promoting neuronal subtype differentiation in embryonic stem cells with light microscope].
  Gao YN, Wang DY, Pan ZF, Mei YQ, Wang ZQ, Zhu DY, Lou YJ.Zhejiang Da Xue Xue Bao Yi Xue Ban. 2012 Jul;41(4):373-80. Chinese.
• 17. Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons             via the PI3-K/Akt signaling pathway.
  Zhang H, Liu B, Wu J, Xu C, Tao J, Duan X, Cao Y, Dong J.Mol Med Report. 2012 Nov;6(5):967-72. doi: 10.3892/mmr.2012.1041. Epub 2012 Aug 21.
• 18. Icariin: a potential promoting compound for cartilage tissue engineering.
  Li D, Yuan T, Zhang X, Xiao Y, Wang R, Fan Y, Zhang X.Osteoarthritis Cartilage. 2012 Dec;20(12):1647-56. doi: 10.1016/j.joca.2012.08.009. Epub 2012 Aug 21.
• 19. Changes in the intestinal absorption mechanism of icariin in the nanocavities of cyclodextrins.
  Zhang Y, Wang QS, Cui YL, Meng FC, Lin KM.Int J Nanomedicine. 2012;7:4239-49. doi: 10.2147/IJN.S33014. Epub 2012 Aug 2.
• 20. [Research on the preparative method of Arctigenin].
  Zhang LY, Yang YS, Zhang T, Ding Y, Cai ZZ, Tao JS.Zhong Yao Cai. 2012 Mar;35(3):467-70. Chinese.

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