Botanical Ingredient

L-theanine Safety Tips

Handling of L-theanine should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway.
  Di X, Yan J, Zhao Y, Chang Y, Zhao B.Sci China Life Sci. 2012 Dec;55(12):1064-74. doi: 10.1007/s11427-012-4401-0. Epub 2012 Dec 12.
• 2. The Involvement of L-Type Amino Acid Transporters in Theanine Transport.
  Yamamoto S, Kimura T, Tachiki T, Anzai N, Sakurai T, Ushimaru M.Biosci Biotechnol Biochem. 2012 Dec 7. [Epub ahead of print]
• 3. [Mechanisms of cerebral protection from ischemia by tea constituents].
  Vlasov TD.Ross Fiziol Zh Im I M Sechenova. 2012 Aug;98(8):929-42. Review. Russian.
• 4. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses.
  Yoto A, Motoki M, Murao S, Yokogoshi H.J Physiol Anthropol. 2012 Oct 29;31(1):28. doi: 10.1186/1880-6805-31-28.
• 5. L-theanine Administration Results in Neuroprotection and Prevents Glutamate Receptor Agonist-Mediated Injury in the Rat Model of Cerebral Ischemia-Reperfusion.
  Zukhurova M, Prosvirnina M, Daineko A, Simanenkova A, Petrishchev N, Sonin D, Galagudza M, Shamtsyan M, Juneja LR, Vlasov T.Phytother Res. 2012 Oct 24. doi: 10.1002/ptr.4868. [Epub ahead of print]
• 6. Kinetics of L-Theanine Uptake and Metabolism in Healthy Participants Are Comparable after Ingestion of L-Theanine via Capsules and Green Tea.
  Scheid L, Ellinger S, Alteheld B, Herholz H, Ellinger J, Henn T, Helfrich HP, Stehle P.J Nutr. 2012 Dec;142(12):2091-6. doi: 10.3945/jn.112.166371. Epub 2012 Oct 24.
• 7. l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice.
  Wise LE, Premaratne ID, Gamage TF, Lichtman AH, Hughes LD, Harris LS, Aceto MD.Pharmacol Biochem Behav. 2012 Dec;103(2):245-52. doi: 10.1016/j.pbb.2012.08.008. Epub 2012 Aug 23.
• 8. Rapid and selective quantification of L-theanine in ready-to-drink teas from Chinese market using SPE and UPLC-UV.
  Chen G, Wang Y, Song W, Zhao B, Dou Y.Food Chem. 2012 Nov 15;135(2):402-7. doi: 10.1016/j.foodchem.2012.04.084. Epub 2012 Apr 30.
• 9. l-Theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation.
  Siamwala JH, Dias PM, Majumder S, Joshi MK, Sinkar VP, Banerjee G, Chatterjee S.J Nutr Biochem. 2012 Jul 20. [Epub ahead of print]
• 10. Protective effect of L-theanine on carbon tetrachloride-induced acute liver injury in mice.
  Jiang W, Gao M, Sun S, Bi A, Xin Y, Han X, Wang L, Yin Z, Luo L.Biochem Biophys Res Commun. 2012 Jun 1;422(2):344-50. doi: 10.1016/j.bbrc.2012.05.022. Epub 2012 May 11.
• 11. L: -Theanine extends lifespan of adult Caenorhabditis elegans.
  Zarse K, Jabin S, Ristow M.Eur J Nutr. 2012 Sep;51(6):765-8. doi: 10.1007/s00394-012-0341-5. Epub 2012 Mar 16.
• 12. Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.
  Foxe JJ, Morie KP, Laud PJ, Rowson MJ, de Bruin EA, Kelly SP.Neuropharmacology. 2012 Jun;62(7):2320-7. doi: 10.1016/j.neuropharm.2012.01.020. Epub 2012 Feb 2.
• 13. L-theanine partially counteracts caffeine-induced sleep disturbances in rats.
  Jang HS, Jung JY, Jang IS, Jang KH, Kim SH, Ha JH, Suk K, Lee MG.Pharmacol Biochem Behav. 2012 Apr;101(2):217-21. doi: 10.1016/j.pbb.2012.01.011. Epub 2012 Jan 21.
• 14. [Raman spectral analysis of theanine].
  Chen YJ, Chen R, Li YZ, Huang ZF, Chen JS, Lin D, Xi GQ.Guang Pu Xue Yu Guang Pu Fen Xi. 2011 Nov;31(11):2961-4. Chinese.
• 15. Tea and cognitive health in late life: current evidence and future directions.
  Song J, Xu H, Liu F, Feng L.J Nutr Health Aging. 2012 Jan;16(1):31-4. Review.
• 16. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial.
  Lyon MR, Kapoor MP, Juneja LR.Altern Med Rev. 2011 Dec;16(4):348-54.
• 17. Nerve and behavioral responses of mice to various umami substances.
  Narukawa M, Morita K, Uemura M, Kitada R, Oh SH, Hayashi Y.Biosci Biotechnol Biochem. 2011;75(11):2125-31. Epub 2011 Nov 7.
• 18. l-Theanine prevents alcoholic liver injury through enhancing the antioxidant capability of hepatocytes.
  Li G, Ye Y, Kang J, Yao X, Zhang Y, Jiang W, Gao M, Dai Y, Xin Y, Wang Q, Yin Z, Luo L.Food Chem Toxicol. 2012 Feb;50(2):363-72. doi: 10.1016/j.fct.2011.10.036. Epub 2011 Oct 14.
• 19. Behavioral and molecular evidence for psychotropic effects in L-theanine.
  Wakabayashi C, Numakawa T, Ninomiya M, Chiba S, Kunugi H.Psychopharmacology (Berl). 2012 Feb;219(4):1099-109. doi: 10.1007/s00213-011-2440-z. Epub 2011 Aug 23.
• 20. Optimum conditions for the water extraction of L-theanine from green tea.
  Vuong QV, Stathopoulos CE, Golding JB, Nguyen MH, Roach PD.J Sep Sci. 2011 Sep;34(18):2468-74. doi: 10.1002/jssc.201100401. Epub 2011 Jul 7.

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