Botanical Ingredient

Lutein (Xanthophyll) Safety Tips

Handling of Lutein (Xanthophyll) should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Plasma carotenoid concentrations in infants are increased by feeding a milk-based infant formula supplemented with carotenoids.
  Mackey AD, Albrecht D, Oliver J, Williams T, Long AC, Price PT.J Sci Food Agric. 2012 Nov 16. doi: 10.1002/jsfa.5996. [Epub ahead of print]
• 2. Independent fluctuations of malate and citrate in the CAM species Clusia hilariana Schltdl. under low light and high light in relation to photoprotection.
  Miszalski Z, Kornas A, Rozp?dek P, Fischer-Schliebs E, Lüttge U.J Plant Physiol. 2012 Dec 17. doi:pii: S0176-1617(12)00513-5.  10.1016/j.jplph.2012.11.005. [Epub ahead of print]
• 3. Effects of increasing concentrations of corn distillers dried grains with solubles on chemical composition and nutrient content of egg.
  Sun H, Lee EJ, Samaraweera H, Persia M, Ahn DU.Poult Sci. 2013 Jan;92(1):233-42. doi: 10.3382/ps.2012-02346.
• 4. Low levels of plasma carotenoids are associated with an increased risk of atrial fibrillation.
  Karppi J, Kurl S, Mäkikallio TH, Ronkainen K, Laukkanen JA.Eur J Epidemiol. 2012 Dec 13. [Epub ahead of print]
• 5. Bioaccessibility of pistachio polyphenols, xanthophylls, and tocopherols during simulated human digestion.
  Mandalari G, Bisignano C, Filocamo A, Chessa S, Sarò M, Torre G, Faulks RM, Dugo P.Nutrition. 2013 Jan;29(1):338-44. doi: 10.1016/j.nut.2012.08.004.
• 6. Assessment of phytochemical content in human milk during different stages of lactation.
  Song BJ, Jouni ZE, Ferruzzi MG.Nutrition. 2013 Jan;29(1):195-202. doi: 10.1016/j.nut.2012.07.015.
• 7. Tomato extract and the carotenoids lycopene and lutein improve endothelial function and attenuate inflammatory NF-κB signaling in endothelial cells.
  Armoza A, Haim Y, Basiri A, Wolak T, Paran E.J Hypertens. 2012 Dec 11. [Epub ahead of print]
• 8. Modeling of Fluorescence Quenching by Lutein in the Plant Light-Harvesting Complex LHCII.
  Duffy CD, Chmeliov J, Macernis M, Sulskus J, Valkunas L, Ruban AV.J Phys Chem B. 2012 Dec 11. [Epub ahead of print]
• 9. Effect of type of TAG fatty acids on lutein and zeaxanthin bioavailability.
  Gleize B, Tourniaire F, Depezay L, Bott R, Nowicki M, Albino L, Lairon D, Kesse-Guyot E, Galan P, Hercberg S, Borel P.Br J Nutr. 2012 Dec 11:1-10. [Epub ahead of print]
• 10. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies.
  Eliassen AH, Hendrickson SJ, Brinton LA, Buring JE, Campos H, Dai Q, Dorgan JF, Franke AA, Gao YT, Goodman MT, Hallmans G, Helzlsouer KJ, Hoffman-Bolton J, Hultén K, Sesso HD, Sowell AL, Tamimi RM, Toniolo P, Wilkens LR, Winkvist A, Zeleniuch-Jacquotte A, Zheng W, Hankinson SE.J Natl Cancer Inst. 2012 Dec 19;104(24):1905-16. doi: 10.1093/jnci/djs461. Epub 2012 Dec 6.
• 11. Macular telangiectasia type 2.
  Charbel Issa P, Gillies MC, Chew EY, Bird AC, Heeren T, Peto T, Holz FG, Scholl HP.Prog Retin Eye Res. 2012 Dec 3. doi:pii: S1350-9462(12)00076-6.  10.1016/j.preteyeres.2012.11.002. [Epub ahead of print]
• 12. Secondary Outcomes in a Clinical Trial of Carotenoids with Coantioxidants versus Placebo in Early Age-Related Macular Degeneration.
  Beatty S, Chakravarthy U, Nolan JM, Muldrew KA, Woodside JV, Denny F, Stevenson MR.Ophthalmology. 2012 Dec 5. doi:pii: S0161-6420(12)00850-0.  10.1016/j.ophtha.2012.08.040. [Epub ahead of print]
• 13. Decreased photochemical efficiency of Photosystem II following sunlight exposure of shade-grown leaves of avocado (Persea americana Mill.): because of, or in spite of, two kinetically distinct xanthophyll cycles?
  Jia H, Förster B, Chow WS, Pogson BJ, Osmond CB.Plant Physiol. 2012 Dec 4. [Epub ahead of print]
• 14. Glare disability, photostress recovery, and chromatic contrast: relation to macular pigment and serum lutein and zeaxanthin.
  Hammond BR Jr, Fletcher LM, Elliott JG.Invest Ophthalmol Vis Sci. 2012 Dec 4. doi:pii: iovs.12-10411v1.  10.1167/iovs.12-10411. [Epub ahead of print]
• 15. Serum response to supplemental macular carotenoids in subjects with and without age-related macular degeneration.
  Meagher KA, Thurnham DI, Beatty S, Howard AN, Connolly E, Cummins W, Nolan JM.Br J Nutr. 2012 Dec 5:1-12. [Epub ahead of print]
• 16. Antioxidant capacity of tomato seed oil in solution and its redox properties in cultured macrophages.
  Mueller L, Catalano A, Simone R, Cittadini A, Froehlich K, Boehm V, Palozza P.J Agric Food Chem. 2012 Dec 3. [Epub ahead of print]
• 17. Effect of Domestic Cooking Methods on Egg Yolk Xanthophylls.
  Nimalaratne C, Lopes-Lutz D, Schieber A, Wu J.J Agric Food Chem. 2012 Dec 14. [Epub ahead of print]
• 18. Analysis of Anabaena vaginicola and Nostoc calcicola from Northern Iran, as rich sources of major carotenoids.
  Hashtroudi MS, Shariatmadari Z, Riahi H, Ghassempour A.Food Chem. 2013 Feb 15;136(3-4):1148-53. doi: 10.1016/j.foodchem.2012.09.055. Epub 2012 Sep 25.
• 19. Small GTPases are involved in sprout formation in human granulosa lutein cells.
  Franz MB, Daube S, Keck C, Sator M, Pietrowski D.Arch Gynecol Obstet. 2012 Nov 30. [Epub ahead of print]
• 20. Effect of carotenoid lutein on N-nitrosodiethylamine-induced hepatocellular carcinoma and its mechanism of action.
  Sindhu ER, Firdous AP, Ramnath V, Kuttan R.Eur J Cancer Prev. 2012 Nov 25. [Epub ahead of print]

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