Botanical Ingredient

Luteolin Safety Tips

Handling of Luteolin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. A comparison study on the binding of hesperetin and luteolin to bovine serum albumin by spectroscopy.
  Tang L, Jia W.Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov 7;103C:114-119. doi: 10.1016/j.saa.2012.10.068. [Epub ahead of print]
• 2. Switching on fluorescence for selective visual recognition of naringenin and morin with a metal-organic coordination polymer of Zn(bix) [bix=1,4-bis(imidazol-1-ylmethyl)benzene].
  Zhao XJ, Wang HJ, Liang LJ, Li YF.Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov 7;103C:68-72. doi: 10.1016/j.saa.2012.11.002. [Epub ahead of print]
• 3. Bioaccessibility of pistachio polyphenols, xanthophylls, and tocopherols during simulated human digestion.
  Mandalari G, Bisignano C, Filocamo A, Chessa S, Sarò M, Torre G, Faulks RM, Dugo P.Nutrition. 2013 Jan;29(1):338-44. doi: 10.1016/j.nut.2012.08.004.
• 4. [Chemical constituents of the roots of Vaccinium bracteatum].
  Lv XL, Mai X, Guo H, Lai XP.Zhong Yao Cai. 2012 Jun;35(6):917-9. Chinese.
• 5. Targeting cell signaling and apoptotic pathways by luteolin: cardioprotective role in rat cardiomyocytes following ischemia/reperfusion.
  Xu T, Li D, Jiang D.Nutrients. 2012 Dec 12;4(12):2008-19. doi: 10.3390/nu4122008.
• 6. Synergistic apoptotic effect of celecoxib and luteolin on breast cancer cells.
  Jeon YW, Suh YJ.Oncol Rep. 2013 Feb;29(2):819-25. doi: 10.3892/or.2012.2158. Epub 2012 Nov 29.
• 7. Effect of luteolin and apigenin on rosmarinic acid bioavailability in Caco-2 cell monolayers.
  Falé PL, Ascensão L, Serralheiro ML.Food Funct. 2012 Dec 6. [Epub ahead of print]
• 8. [The influence of different processing on the content of flavones of Dendranthema morifolium].
  Jin CS, Wu DL, Yu NJ, Chen HF, Wang TS, Zhang W.Zhong Yao Cai. 2012 May;35(5):702-4. Chinese.
• 9. Induction of melanogenesis by 4′-O-methylated flavonoids in B16F10 melanoma cells.
  Horibe I, Satoh Y, Shiota Y, Kumagai A, Horike N, Takemori H, Uesato S, Sugie S, Obata K, Kawahara H, Nagaoka Y.J Nat Med. 2012 Dec 4. [Epub ahead of print]
• 10. Antifeedant activity of luteolin and genistein against the pea aphid, Acyrthosiphon pisum.
  Go?awska S, Lukasik I.J Pest Sci (2004). 2012 Dec;85(4):443-450. Epub 2012 Jun 22.
• 11. Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway.
  Lucas CD, Allen KC, Dorward DA, Hoodless LJ, Melrose LA, Marwick JA, Tucker CS, Haslett C, Duffin R, Rossi AG.FASEB J. 2012 Nov 29. [Epub ahead of print]
• 12. Inhibition of Angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies.
  Guerrero L, Castillo J, Quiñones M, Garcia-Vallvé S, Arola L, Pujadas G, Muguerza B.PLoS One. 2012;7(11):e49493. doi: 10.1371/journal.pone.0049493. Epub 2012 Nov 21.
• 13. Centipede grass exerts anti-adipogenic activity through inhibition of C/EBPbeta, C/EBPalpha, and PPARgamma expression and the AKT signaling pathway in 3T3-L1 adipocytes.
  Park HJ, Chung BY, Lee MK, Song Y, Lee SS, Chu GM, Kang SN, Song YM, Kim GS, Cho JH.BMC Complement Altern Med. 2012 Nov 26;12(1):230. [Epub ahead of print]
• 14. A New Prenylated Naphthoquinoid from the Aerial Parts of Clinopodium chinense (Benth.) O. Kuntze.
  Zhong M, Sun G, Zhang X, Sun G, Xu X, Yu S.Molecules. 2012 Nov 23;17(12):13910-6. doi: 10.3390/molecules171213910.
• 15. Raf and PI3K are the Molecular Targets for the Anti-metastatic Effect of Luteolin.
  Kim HY, Jung SK, Byun S, Son JE, Oh MH, Lee J, Kang MJ, Heo YS, Lee KW, Lee HJ.Phytother Res. 2012 Nov 21. doi: 10.1002/ptr.4888. [Epub ahead of print]
• 16. Luteolin Inhibits Angiotensin II-Induced Human Umbilical Vein Endothelial Cell Proliferation and Migration Through Downregulation of Src and Akt Phosphorylation.
  Zhu M, Chen D, Li D, Ding H, Zhang T, Xu T, Zhang Y.Circ J. 2012 Nov 22. [Epub ahead of print]
• 17. Influences of glucose on the dietary hydroxyflavonoid-plasma protein interaction.
  Wang Y, Zhao Y, Yang F, Yuan Y, Wang H, Xiao J.J Agric Food Chem. 2012 Dec 12;60(49):12116-21. doi: 10.1021/jf303094e. Epub 2012 Nov 28.
• 18. Synergistic activity of luteolin and amoxicillin combination against amoxicillin-resistant Escherichia coli and mode of action.
  Eumkeb G, Siriwong S, Thumanu K.J Photochem Photobiol B. 2012 Dec 5;117:247-53. doi: 10.1016/j.jphotobiol.2012.10.006. Epub 2012 Oct 26.
• 19. Evaluation of the ion trap MS performance for quantification of flavonoids and comparison to UV detection.
  Stanoeva JP, Stefova M.J Mass Spectrom. 2012 Nov;47(11):1395-406. doi: 10.1002/jms.3053.
• 20. UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-d-glucoside and luteolin-7-O-β-d-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection.
  Yin R, Han F, Tang Z, Liu R, Zhao X, Chen X, Bi K.J Pharm Biomed Anal. 2013 Jan;72:127-33. doi: 10.1016/j.jpba.2012.09.028. Epub 2012 Oct 8.

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