Botanical Ingredient

Naringenin Safety Tips

Handling of Naringenin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Switching on fluorescence for selective visual recognition of naringenin and morin with a metal-organic coordination polymer of Zn(bix) [bix=1,4-bis(imidazol-1-ylmethyl)benzene].
  Zhao XJ, Wang HJ, Liang LJ, Li YF.Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov 7;103C:68-72. doi: 10.1016/j.saa.2012.11.002. [Epub ahead of print]
• 2. Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain.
  Kaulaskar S, Bhutada P, Rahigude A, Jain D, Harle U.Zhong Xi Yi Jie He Xue Bao. 2012 Dec;10(12):1482-9. doi: 10.3736/jcim20121223.
• 3. Phytochemical Stability in Dried Tomato Pulp and Peel as Affected by Moisture Properties.
  Lavelli V, Kerr WL, Pedapati SH.J Agric Food Chem. 2012 Dec 21. [Epub ahead of print]
• 4. Citrus flavonoids and lipid metabolism.
  Assini JM, Mulvihill EE, Huff MW.Curr Opin Lipidol. 2012 Dec 18. [Epub ahead of print]
• 5. Metabolic engineering of the flavone-C-glycoside pathway using polyprotein technology.
  Brazier-Hicks M, Edwards R.Metab Eng. 2012 Dec 13. doi:pii: S1096-7176(12)00121-8.  10.1016/j.ymben.2012.11.004. [Epub ahead of print]
• 6. Gas-phase dissociative electron attachment to flavonoids and possible similarities to their metabolic pathways.
  Modelli A, Pshenichnyuk SA.Phys Chem Chem Phys. 2012 Dec 17. [Epub ahead of print]
• 7. Metabolomic profiling in Selaginella lepidophylla at various hydration states provides new insights into the mechanistic basis of desiccation tolerance.
  Yobi A, Wone BM, Xu W, Alexander DC, Guo L, Ryals JA, Oliver MJ, Cushman JC.Mol Plant. 2012 Dec 13. [Epub ahead of print]
• 8. Assessment of phytochemical content in human milk during different stages of lactation.
  Song BJ, Jouni ZE, Ferruzzi MG.Nutrition. 2013 Jan;29(1):195-202. doi: 10.1016/j.nut.2012.07.015.
• 9. Chemopreventive Efficacy of Naringenin-Loaded Nanoparticles in 7,12-dimethylbenz(a)anthracene Induced Experimental Oral Carcinogenesis.
  Sulfikkarali N, Krishnakumar N, Manoharan S, Nirmal RM.Pathol Oncol Res. 2012 Dec 12. [Epub ahead of print]
• 10. Discrimination of the rare medicinal plant Dendrobium officinale based on naringenin, bibenzyl, and polysaccharides.
  Chen X, Wang F, Wang Y, Li X, Wang A, Wang C, Guo S.Sci China Life Sci. 2012 Dec;55(12):1092-9. doi: 10.1007/s11427-012-4419-3. Epub 2012 Dec 12.
• 11. Synergistic activity and mechanism of action of ceftazidime and apigenin combination against ceftazidime-resistant Enterobacter cloacae.
  Eumkeb G, Chukrathok S.Phytomedicine. 2012 Dec 3. doi:pii: S0944-7113(12)00374-1.  10.1016/j.phymed.2012.10.008. [Epub ahead of print]
• 12. De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae.
  Koopman F, Beekwilder J, Crimi B, Houwelingen A, Hall RD, Bosch D, van Maris AJ, Pronk JT, Daran JM.Microb Cell Fact. 2012 Dec 8;11(1):155. [Epub ahead of print]
• 13. The inhibitory effect of polyphenols on human gut microbiota.
  Duda-Chodak A.J Physiol Pharmacol. 2012 Oct;63(5):497-503.
• 14. Mesenteric Lymphatic Absorption and the Pharmacokinetics of Naringin and Naringenin in the Rat.
  Tsai YJ, Tsai TH.J Agric Food Chem. 2012 Dec 14. [Epub ahead of print]
• 15. Effect of β-cyclodextrin complexation on solubility and enzymatic conversion of naringin.
  Cui L, Zhang ZH, Sun E, Jia XB.Int J Mol Sci. 2012 Nov 5;13(11):14251-61. doi: 10.3390/ijms131114251.
• 16. Isolation of Prunin from the fruit shell of Bixa orellana and the effect of β-cyclodextrin on its binding with calf thymus DNA.
  Yousuf S, Sudha N, Murugesan G, Enoch IV.Carbohydr Res. 2012 Oct 12;365C:46-51. doi: 10.1016/j.carres.2012.10.003. [Epub ahead of print]
• 17. Naringenin prevents high glucose-induced mitochondria-mediated apoptosis involving AIF, Endo-G and caspases.
  Kapoor R, Rizvi F, Kakkar P.Apoptosis. 2012 Nov 29. [Epub ahead of print]
• 18. Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3.
  Straub I, Mohr F, Stab J, Konrad M, Philipp S, Oberwinkler J, Schaefer M.Br J Pharmacol. 2012 Nov 28. doi: 10.1111/bph.12076. [Epub ahead of print]
• 19. Flavonoids and polymer derivatives as CYP3A4 inhibitors for improved oral drug bioavailability.
  Fasinu P, Choonara YE, Khan RA, Du Toit LC, Kumar P, K Ndesendo VM, Pillay V.J Pharm Sci. 2012 Nov 27. doi: 10.1002/jps.23382. [Epub ahead of print]
• 20. Preconcentration of flavonoids on polyurethane foam and their direct determination by diffuse reflectance spectroscopy.
  Dmitrienko SG, Apyari VV, Kudrinskaya VA, Stepanova AV.Talanta. 2012 Dec 15;102:132-6. doi: 10.1016/j.talanta.2012.08.017. Epub 2012 Aug 21.

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