Botanical Ingredient

Nobiletin Safety Tips

Handling of Nobiletin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Citrus flavonoids and lipid metabolism.
  Assini JM, Mulvihill EE, Huff MW.Curr Opin Lipidol. 2012 Dec 18. [Epub ahead of print]
• 2. Polymethoxyflavones as agents that prevent formation of cataract: Nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells.
  Miyata Y, Oshitari T, Okuyama Y, Shimada A, Takahashi H, Natsugari H, Kosano H.Bioorg Med Chem Lett. 2013 Jan 1;23(1):183-7. doi: 10.1016/j.bmcl.2012.10.133. Epub 2012 Nov 9.
• 3. Antioxidant activity and effective compounds of immature calamondin peel.
  Yu MW, Lou SN, Chiu EM, Ho CT.Food Chem. 2013 Feb 15;136(3-4):1130-5. doi: 10.1016/j.foodchem.2012.09.088. Epub 2012 Oct 2.
• 4. Chemical constituents of Arisaema franchetianum tubers.
  Su Y, Xu JJ, Bi JL, Wang YH, Hu GW, Yang J, Yin GF, Long CL.J Asian Nat Prod Res. 2012 Oct 29. [Epub ahead of print]
• 5. Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes.
  Ihara H, Yamamoto H, Ida T, Tsutsuki H, Sakamoto T, Fujita T, Okada T, Kozaki S.Biosci Biotechnol Biochem. 2012;76(10):1843-8. Epub 2012 Oct 7.
• 6. Chemical markers of shiikuwasha juice adulterated with calamondin juice.
  Yamamoto K, Yahada A, Sasaki K, Ogawa K, Koga N, Ohta H.J Agric Food Chem. 2012 Nov 7;60(44):11182-7. doi: 10.1021/jf303374g. Epub 2012 Oct 26.
• 7. Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress.
  Chen ZT, Chu HL, Chyau CC, Chu CC, Duh PD.Food Chem. 2012 Dec 15;135(4):2119-27. doi: 10.1016/j.foodchem.2012.07.041. Epub 2012 Jul 15.
• 8. Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells.
  Shen W, Xu Y, Lu YH.J Agric Food Chem. 2012 Sep 26;60(38):9609-19. Epub 2012 Sep 17.
• 9. HPLC-PDA-MS and NMR Characterization of a Hydroalcoholic Extract of  Citrus aurantium  L. var. amara Peel with Antiedematogenic Activity.
  Mencherini T, Campone L, Piccinelli AL, García Mesa M, Sánchez DM, Aquino RP, Rastrelli L.J Agric Food Chem. 2012 Sep 17. [Epub ahead of print]
• 10. Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice.
  Lee YS, Cha BY, Choi SS, Choi BK, Yonezawa T, Teruya T, Nagai K, Woo JT.J Nutr Biochem. 2013 Jan;24(1):156-62. doi: 10.1016/j.jnutbio.2012.03.014. Epub 2012 Aug 13.
• 11. Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9.
  Baek SH, Kim SM, Nam D, Lee JH, Ahn KS, Choi SH, Kim SH, Shim BS, Chang IM, Ahn KS.Pharm Biol. 2012 Oct;50(10):1210-8. doi: 10.3109/13880209.2012.664151. Epub 2012 Aug 2.
• 12. Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis.
  Tominari T, Hirata M, Matsumoto C, Inada M, Miyaura C.J Pharmacol Sci. 2012 Aug 18;119(4):390-4. Epub 2012 Jul 31.
• 13. Dietary polyphenols and mechanisms of osteoarthritis.
  Shen CL, Smith BJ, Lo DF, Chyu MC, Dunn DM, Chen CH, Kwun IS.J Nutr Biochem. 2012 Nov;23(11):1367-77. doi: 10.1016/j.jnutbio.2012.04.001. Epub 2012 Jul 23.
• 14. The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines.
  Asikin Y, Taira I, Inafuku-Teramoto S, Sumi H, Ohta H, Takara K, Wada K.J Agric Food Chem. 2012 Aug 15;60(32):7973-80. doi: 10.1021/jf301848s. Epub 2012 Jul 31.
• 15. Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.
  Surichan S, Androutsopoulos VP, Sifakis S, Koutala E, Tsatsakis A, Arroo RR, Boarder MR.Food Chem Toxicol. 2012 Sep;50(9):3320-8. doi: 10.1016/j.fct.2012.06.030. Epub 2012 Jun 26.
• 16. In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent.
  Lam IK, Alex D, Wang YH, Liu P, Liu AL, Du GH, Lee SM.Mol Nutr Food Res. 2012 Jun;56(6):945-56. doi: 10.1002/mnfr.201100680.
• 17. Mild Mitochondrial Depolarization is Involved in a Neuroprotective Mechanism of Citrus sunki Peel Extract.
  Wu JJ, Cui Y, Yang YS, Jung SC, Hyun JW, Maeng YH, Park DB, Lee SR, Kim SJ, Eun SY.Phytother Res. 2012 Jun 8. doi: 10.1002/ptr.4745. [Epub ahead of print]
• 18. Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities.
  Loizzo MR, Tundis R, Bonesi M, Menichini F, De Luca D, Colica C, Menichini F.J Sci Food Agric. 2012 Dec;92(15):2960-7. doi: 10.1002/jsfa.5708. Epub 2012 May 16.
• 19. Polymethoxyflavonoids Tangeretin and Nobiletin Increase Glucose Uptake in Murine Adipocytes.
  Onda K, Horike N, Suzuki TI, Hirano T.Phytother Res. 2012 May 14. doi: 10.1002/ptr.4730. [Epub ahead of print]
• 20. Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.
  Shih WL, Yu FL, Chang CD, Liao MH, Wu HY, Lin PY.Mol Carcinog. 2012 Apr 30. doi: 10.1002/mc.21919. [Epub ahead of print]

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