Botanical Ingredient

Oleanolic Acid Safety Tips

Handling of Oleanolic Acid should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. [The anti-portal hypertension effect of oleanolic acid in CCl4-induced cirrhosis rats].
  Liu CH, Huang XT, Li YY, Zheng X, Li N, Mi SQ, Wang NS.Zhong Yao Cai. 2012 Jun;35(6):930-5. Chinese.
• 2. [Chemical constituents of the roots of Vaccinium bracteatum].
  Lv XL, Mai X, Guo H, Lai XP.Zhong Yao Cai. 2012 Jun;35(6):917-9. Chinese.
• 3. Anti-herpes virus activities of Achyranthes aspera: An Indian ethnomedicine, and its triterpene acid.
  Mukherjee H, Ojha D, Bag P, Chandel HS, Bhattacharyya S, Chatterjee TK, Mukherjee PK, Chakraborti S, Chattopadhyay D.Microbiol Res. 2012 Dec 4. doi:pii: S0944-5013(12)00122-X.  10.1016/j.micres.2012.11.002. [Epub ahead of print]
• 4. [Determination of oleanolic acid and ursolic acid in Damnacanthus indicus from different places by RP-hPLC].
  Cai YF, Huang QS.Zhong Yao Cai. 2012 May;35(5):694-6. Chinese.
• 5. The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications.
  Alqahtani A, Hamid K, Kam A, Wong KH, Abdelhak Z, Razmovski-Naumovski V, Chan K, Li KM, Groundwater PW, Li GQ.Curr Med Chem. 2012 Dec 3. [Epub ahead of print]
• 6. Triterpene Saponin Content in the Roots of Red Beet (Beta vulgaris L.) Cultivars.
  Mroczek A, Kapusta I, Janda B, Janiszowska W.J Agric Food Chem. 2012 Dec 19;60(50):12397-402. doi: 10.1021/jf303952x. Epub 2012 Dec 11.
• 7. A New Ursane-Type Nor-Triterpenoid from the Leaves of Eucommia ulmoides Oliv.
  Li C, Li L, Wang C, Yang J, Ye F, Tian J, Si Y, Zhang D.Molecules. 2012 Nov 26;17(12):13960-8. doi: 10.3390/molecules171213960.
• 8. Flavonoids bearing an O-arabinofuranosyl-(1–>3)-rhamnoside moiety from Cladocolea micrantha: inhibitory effect on human melanoma cells.
  Guimarães AC, Magalhães A, Nakamura MJ, Siani AC, Barja-Fidalgo C, Sampaio AL.Nat Prod Commun. 2012 Oct;7(10):1311-4.
• 9. Antidepressant-like effect of oleanolic acid in mice exposed to the repeated forced swimming test.
  Yi LT, Li J, Liu Q, Geng D, Zhou YF, Ke XQ, Chen H, Weng LJ.J Psychopharmacol. 2012 Nov 13. [Epub ahead of print]
• 10. Triterpenoid profile of flower and leaf cuticular waxes of heather Calluna vulgaris.
  Szakiel A, Ni?ynski B, P?czkowski C.Nat Prod Res. 2012 Nov 13. [Epub ahead of print]
• 11. Fast separation of triterpenoids by supercritical fluid chromatography/evaporative light scattering detector.
  Lesellier E, Destandau E, Grigoras C, Fougère L, Elfakir C.J Chromatogr A. 2012 Dec 14;1268:157-65. doi: 10.1016/j.chroma.2012.09.102. Epub 2012 Oct 22.
• 12. In Vivo prophylactic effects of oleanolic acid isolated from chloroform extract of Flaveria trinervia against ethanol induced liver toxicity in rats.
  Joy Hoskeri H, Krishna V, Vinay Kumar B, Shridar AH, Ramesh Babu K, Sudarshana MS.Arch Pharm Res. 2012 Oct;35(10):1803-10. doi: 10.1007/s12272-012-1013-y. Epub 2012 Nov 9.
• 13. Simultaneous determination of seven major triterpenoids in Pyrola decorata H. Andres by LC-MS method.
  Zhang YY, Zhang C, Ren R, Liu R.Pharmazie. 2012 Oct;67(10):822-6.
• 14. Bioactive constituents of Salvia chrysophylla Stapf.
  Culhao?lu B, Yapar G, Dirmenci T, Topçu G.Nat Prod Res. 2012 Nov 6. [Epub ahead of print]
• 15. [Non-anthraquinones constituents from the roots of Knoxia valerianoides].
  Zhao F, Wang S, Wu X, Yu Y, Yue Z, Liu B, Lin S, Zhu C, Yang Y, Shi J.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(14):2092-9. Chinese.
• 16. Synthesis and docking studies of novel antitumor benzimidazoles.
  Omar MA, Shaker YM, Galal SA, Ali MM, Kerwin SM, Li J, Tokuda H, Ramadan RA, El Diwani HI.Bioorg Med Chem. 2012 Dec 15;20(24):6989-7001. doi: 10.1016/j.bmc.2012.10.010. Epub 2012 Oct 16.
• 17. A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients.
  Caligiani A, Malavasi G, Palla G, Marseglia A, Tognolini M, Bruni R.Food Chem. 2013 Jan 15;136(2):735-41. doi: 10.1016/j.foodchem.2012.08.011. Epub 2012 Aug 16.
• 18. The in vitro study of ursolic acid and oleanolic acid inhibiting cariogenic microorganisms as well as biofilm.
  Zhou L, Ding Y, Chen W, Zhang P, Chen Y, Lv X.Oral Dis. 2012 Oct 1. doi: 10.1111/odi.12031. [Epub ahead of print]
• 19. Standardized Clitoria ternatea leaf extract as hyaluronidase, elastase and matrix-metalloproteinase-1 inhibitor.
  Maity N, Nema NK, Sarkar BK, Mukherjee PK.Indian J Pharmacol. 2012 Sep;44(5):584-7. doi: 10.4103/0253-7613.100381.
• 20. Plant metabolomics: Resolution and quantification of elusive peaks in liquid chromatography-mass spectrometry profiles of complex plant extracts using multi-way decomposition methods.
  Khakimov B, Amigo JM, Bak S, Engelsen SB.J Chromatogr A. 2012 Nov 30;1266:84-94. doi: 10.1016/j.chroma.2012.10.023. Epub 2012 Oct 16.

Details