Botanical Ingredient

Acetyl-resveratrol Safety Tips

Handling of Acetyl-resveratrol should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Resveratrol analog 4-[2-(3,5-dimethoxyphenyl)vinyl]pyridine reduces differentiation of the 3T3-L1 adipocyte.
  Hwang JT, Kim S, Choi I, Choi SY.Pharm Biol. 2013 Jan;51(1):96-9. doi: 10.3109/13880209.2012.711841. Epub 2012 Oct 5.
• 2. Acute exposure to resveratrol inhibits AMPK activity in human skeletal muscle cells.
  Skrobuk P, von Kraemer S, Semenova MM, Zitting A, Koistinen HA.Diabetologia. 2012 Nov;55(11):3051-60. doi: 10.1007/s00125-012-2691-1. Epub 2012 Aug 17.
• 3. Production of resveratrol from tyrosine in metabolically engineered Saccharomyces cerevisiae.
  Shin SY, Jung SM, Kim MD, Han NS, Seo JH.Enzyme Microb Technol. 2012 Sep 10;51(4):211-6. doi: 10.1016/j.enzmictec.2012.06.005. Epub 2012 Jun 28.
• 4. Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization.
  Anderson G, Maes M, Berk M.Adv Protein Chem Struct Biol. 2012;88:27-48. doi: 10.1016/B978-0-12-398314-5.00002-7. Review.
• 5. Isolation of antitrypanosomal compounds from Vitis repens, a medicinal plant of Myanmar.
  Nyunt KS, Elkhateeb A, Tosa Y, Nabata K, Katakura K, Matsuura H.Nat Prod Commun. 2012 May;7(5):609-10.
• 6. A new nonpeptide substrate of human sirtuin in a capillary electrophoresis-based assay. Investigation of the binding mode by docking experiments.
  Abromeit H, Kannan S, Sippl W, Scriba GK.Electrophoresis. 2012 Jun;33(11):1652-9. doi: 10.1002/elps.201100641.
• 7. Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
  Radnai B, Antus C, Racz B, Engelmann P, Priber JK, Tucsek Z, Veres B, Turi Z, Lorand T, Sumegi B, Gallyas F Jr.Mol Cancer. 2012 May 14;11:34. doi: 10.1186/1476-4598-11-34.
• 8. Resveratrol augments nitric oxide generation and causes stored calcium release in chromaffin cells.
  Padín JF, de Diego AM, Fernández-Morales JC, Merino C, Maroto M, Calvo-Gallardo E, Arranz JA, Yáñez M, García AG.Eur J Pharmacol. 2012 Jun 15;685(1-3):99-107. doi: 10.1016/j.ejphar.2012.03.040. Epub 2012 Apr 3.
• 9. Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes.
  Krawczyk SA, Haller JF, Ferrante T, Zoeller RA, Corkey BE.PLoS One. 2012;7(4):e34904. doi: 10.1371/journal.pone.0034904. Epub 2012 Apr 6.
• 10. Proteomics analysis of human umbilical vein endothelial cells treated with resveratrol.
  Shao B, Tang M, Li Z, Zhou R, Deng Y, Nie C, Yuan Z, Zhou L, Tang M, Tong A, Wei Y.Amino Acids. 2012 Oct;43(4):1671-8. Epub 2012 Feb 18.
• 11. High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol.
  Zhang L, Pang S, Deng B, Qian L, Chen J, Zou J, Zheng J, Yang L, Zhang C, Chen X, Liu Z, Le Y.Int J Biochem Cell Biol. 2012 Apr;44(4):629-38. doi: 10.1016/j.biocel.2012.01.001. Epub 2012 Jan 9.
• 12. 5-[2-(4-Acetyl-oxyphen-yl)ethen-yl]benzene-1,3-diyl diacetate.
  Tang L, Dai D, Gong Y, Zhong J.Acta Crystallogr Sect E Struct Rep Online. 2011 Nov;67(Pt 11):o3129. doi: 10.1107/S1600536811044722. Epub 2011 Oct 29.
• 13. Resveratrol induces apoptosis via ROS-triggered autophagy in human colon             cancer cells.
  Miki H, Uehara N, Kimura A, Sasaki T, Yuri T, Yoshizawa K, Tsubura A.Int J Oncol. 2012 Apr;40(4):1020-8. doi: 10.3892/ijo.2012.1325. Epub 2012 Jan 3.
• 14. Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells.
  Yi CO, Jeon BT, Shin HJ, Jeong EA, Chang KC, Lee JE, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS.Anat Cell Biol. 2011 Sep;44(3):194-203. doi: 10.5115/acb.2011.44.3.194. Epub 2011 Sep 29.
• 15. Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology.
  Kodiha M, Ho-Wo-Cheong D, Stochaj U.Am J Physiol Cell Physiol. 2011 Dec;301(6):C1307-15. doi: 10.1152/ajpcell.00309.2011. Epub 2011 Sep 14.
• 16. Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice.
  Shiozaki M, Hayakawa N, Shibata M, Koike M, Uchiyama Y, Gotow T.Histochem Cell Biol. 2011 Oct;136(4):475-89. doi: 10.1007/s00418-011-0847-6. Epub 2011 Aug 5.
• 17. Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress.
  Gómez-Zorita S, Fernández-Quintela A, Macarulla MT, Aguirre L, Hijona E, Bujanda L, Milagro F, Martínez JA, Portillo MP.Br J Nutr. 2012 Jan;107(2):202-10. doi: 10.1017/S0007114511002753. Epub 2011 Jun 28.
• 18. Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4,                      PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver.
  Schirmer H, Pereira TC, Rico EP, Rosemberg DB, Bonan CD, Bogo MR, Souto AA.Mol Biol Rep. 2012 Mar;39(3):3281-9. doi: 10.1007/s11033-011-1096-4. Epub 2011 Jun 25.
• 19. Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis.
  Vingtdeux V, Chandakkar P, Zhao H, Davies P, Marambaud P.Mol Med. 2011 Sep-Oct;17(9-10):1022-30. doi: 10.2119/molmed.2011.00163. Epub 2011 Jun 1.
• 20. Nutritional approaches to modulate oxidative stress in Alzheimer’s disease.
  Pocernich CB, Lange ML, Sultana R, Butterfield DA.Curr Alzheimer Res. 2011 Aug;8(5):452-69. Review.

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