Botanical Ingredient

Paeoniflorin Safety Tips

Handling of Paeoniflorin should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Inhibitory effects of paeoniflorin on lysophosphatidylcholine-induced inflammatory factor production in human umbilical vein endothelial cells.
  Li JZ, Wu JH, Yu SY, Shao QR, Dong XM.Int J Mol Med. 2012 Dec 13. doi: 10.3892/ijmm.2012.1211. [Epub ahead of print]
• 2. Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats.
  Chen X, Liu C, Lu Y, Yang Z, Lv Z, Xu Q, Pan Q, Lu L.BMC Complement Altern Med. 2012 Dec 13;12(1):254. [Epub ahead of print]
• 3. [Chemical constituents of glucoside fraction from Liuwei Dihuang Gantang].
  Wang XY, Sun L, Qiao SY.Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2576-80. Chinese.
• 4. [Protective effect of paeoniflorin on Abeta25-35 -induced PC12 cell injury].
  Wang S, Liu L.Zhongguo Zhong Yao Za Zhi. 2012 Aug;37(16):2448-51. Chinese.
• 5. Paeoniflorin protects myocardial cell from doxorubicin-induced apoptosis through inhibition of NADPH oxidase.
  Li JZ, Yu SY, Wu JH, Shao QR, Dong XM.Can J Physiol Pharmacol. 2012 Dec;90(12):1569-75. doi: 10.1139/y2012-140. Epub 2012 Nov 19.
• 6. UPLC-QTOF-MS with chemical profiling approach for rapidly evaluating chemical consistency between traditional and dispensing granule decoctions of Tao-Hong-Si-Wu decoction.
  Shang E, Zhu Z, Liu L, Tang Y, Duan JA.Chem Cent J. 2012 Nov 24;6(1):143. [Epub ahead of print]
• 7. Paeoniflorin Protects against Ischemia-Induced Brain Damages in Rats via Inhibiting MAPKs/NF-κB-Mediated Inflammatory Responses.
  Guo RB, Wang GF, Zhao AP, Gu J, Sun XL, Hu G.PLoS One. 2012;7(11):e49701. doi: 10.1371/journal.pone.0049701. Epub 2012 Nov 14.
• 8. Moutan Cortex Radicis inhibits inflammatory changes of gene expression in lipopolysaccharide-stimulated gingival fibroblasts.
  Yun CS, Choi YG, Jeong MY, Lee JH, Lim S.J Nat Med. 2012 Oct 20. [Epub ahead of print]
• 9. Application of quantitative (1)H-NMR method to determination of paeoniflorin in Paeoniae radix.
  Tanaka R, Yamazaki M, Hasada K, Nagatsu A.J Nat Med. 2012 Oct 19. [Epub ahead of print]
• 10. Involvement of the prostaglandin E receptor EP2 in paeoniflorin-induced human hepatoma cell apoptosis.
  Hu S, Sun W, Wei W, Wang D, Jin J, Wu J, Chen J, Wu H, Wang Q.Anticancer Drugs. 2013 Feb;24(2):140-9. doi: 10.1097/CAD.0b013e32835a4dac.
• 11. Paeoniflorin Attenuates Lipopolysaccharide-Induced Permeability of Endothelial Cells: Involvements of F-Actin Expression and Phosphorylations of PI3K/Akt and PKC.
  Xu H, Song J, Gao X, Xu Z, Xu X, Xia Y, Dai Y.Inflammation. 2012 Oct 3. [Epub ahead of print]
• 12. Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2/Bax signal pathway.
  Sun R, Wang K, Wu D, Li X, Ou Y.Folia Neuropathol. 2012;50(3):270-6.
• 13. [Multi-channel analysis and comparison on absorption difference between paeoniflorin and Paeonia lactiflora extracts].
  Chen Y, Zhou L, Xin R, Wang J, Jia X.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):2012-6. Chinese.
• 14. [Impact of saikosaponin on absorption and transport of paeoniflorin in Caco-2 cell model].
  Chen Y, Wang J, Xin R, Tan X.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1850-4. Chinese.
• 15. [Study on in vitro and in vivo material base of Sini San by UPLC-PDA-MS/MS].
  Qiao Y, Wen J, Song Y, Lu X, Xiong Z, Li F.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1672-6. Chinese.
• 16. HPLC-MS/MS analysis of a traditional Chinese medical formulation of Bu-Yang-Huan-Wu-Tang and its pharmacokinetics after oral administration to rats.
  Shaw LH, Lin LC, Tsai TH.PLoS One. 2012;7(8):e43848. doi: 10.1371/journal.pone.0043848. Epub 2012 Aug 29.
• 17. Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children.
  Hino H, Takahashi H, Suzuki Y, Tanaka J, Ishii E, Fukuda M.PLoS One. 2012;7(8):e42920. doi: 10.1371/journal.pone.0042920. Epub 2012 Aug 16.
• 18. Detection of sulfur-fumigated Paeoniae Alba Radix in complex preparations by high performance liquid chromatography tandem mass spectrometry.
  Wu J, Shen H, Xu J, Zhu LY, Jia XB, Li SL.Molecules. 2012 Jul 26;17(8):8938-54. doi: 10.3390/molecules17088938.
• 19. Paeoniflorin inhibits function and down-regulates HLA-DR and CD80 expression of human peripheral blood monocytes stimulated by rhIL-1β.
  Wang D, Yuan F, Wang L, Wei W.Int Immunopharmacol. 2012 Oct;14(2):172-8. doi: 10.1016/j.intimp.2012.07.005. Epub 2012 Jul 24.
• 20. [Protective effects of paeonol, paeoniflorin and their compatibility on in vitro cultured cardiomyocytes suffering from hypoxia-reoxygenation injury].
  Zhang JY, Li P, Li YK.Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Apr;32(4):510-4. Chinese.

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