Botanical Ingredient

Palmatine Safety Tips

Handling of Palmatine should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Pharmacokinetics and Relative Bioavailability of Flavonoids between Two Dosage Forms of Gegen-Qinlian-Tang in Rats.
  Yu CP, Shia CS, Tsai SY, Hou YC.Evid Based Complement Alternat Med. 2012;2012:308018. doi: 10.1155/2012/308018. Epub 2012 Nov 1.
• 2. Preparation of micropipette tip-based molecularly imprinted monolith for selective micro-solid phase extraction of berberine in plasma and urine samples.
  Zhang W, Chen Z.Talanta. 2013 Jan 15;103:103-9. doi: 10.1016/j.talanta.2012.10.014. Epub 2012 Oct 11.
• 3. Memory-enhancing activity of palmatine in mice using elevated plus maze and morris water maze.
  Dhingra D, Kumar V.Adv Pharmacol Sci. 2012;2012:357368. doi: 10.1155/2012/357368. Epub 2012 Nov 1.
• 4. Quantitative determination of alkaloids from roots of Hydrastis canadensis L. and dietary supplements using ultra-performance liquid chromatography with UV detection.
  Avula B, Wang YH, Khan IA.J AOAC Int. 2012 Sep-Oct;95(5):1398-405.
• 5. Safety evaluation of main alkaloids from Rhizoma Coptidis.
  Yi J, Ye X, Wang D, He K, Yang Y, Liu X, Li X.J Ethnopharmacol. 2012 Nov 16. doi:pii: S0378-8741(12)00767-2.  10.1016/j.jep.2012.10.062. [Epub ahead of print]
• 6. Novel mitochondria-targeted compounds composed of natural constituents: conjugates of plant alkaloids berberine and palmatine with plastoquinone.
  Chernyak BV, Antonenko YN, Galimov ER, Domnina LV, Dugina VB, Zvyagilskaya RA, Ivanova OY, Izyumov DS, Lyamzaev KG, Pustovidko AV, Rokitskaya TI, Rogov AG, Severina II, Simonyan RA, Skulachev MV, Tashlitsky VN, Titova EV, Trendeleva TA, Shagieva GS.Biochemistry (Mosc). 2012 Sep;77(9):983-95. doi: 10.1134/S0006297912090040.
• 7. Binding of isoquinoline alkaloids berberine, palmatine and coralyne to hemoglobin: structural and thermodynamic characterization studies.
  Hazra S, Hossain M, Suresh Kumar G.Mol Biosyst. 2013 Jan 27;9(1):143-53. doi: 10.1039/c2mb25345c. Epub 2012 Nov 13.
• 8. New antiplasmodial alkaloids from Stephania rotunda.
  Baghdikian B, Mahiou-Leddet V, Bory S, Bun SS, Dumetre A, Mabrouki F, Hutter S, Azas N, Ollivier E.J Ethnopharmacol. 2012 Nov 2. doi:pii: S0378-8741(12)00749-0.  10.1016/j.jep.2012.10.052. [Epub ahead of print]
• 9. Comparison the neuropreotective effect of Cortex Phellodendri chinensis and Cortex Phellodendri amurensis against beta-amyloid-induced neurotoxicity in PC12 cells.
  Xian YF, Lin ZX, Ip SP, Su ZR, Chen JN, Lai XP.Phytomedicine. 2012 Nov 1. doi:pii: S0944-7113(12)00364-9.  10.1016/j.phymed.2012.09.028. [Epub ahead of print]
• 10. Novel penetrating cations for targeting mitochondria.
  Chernyak BV, Antonenko YN, Domnina LV, Ivanova OY, Lyamzaev KG, Pustovidko AV, Rokitskaya TI, Severina II, Simonyan RA, Trendeleva TA, Zvyagilskaya RA.Curr Pharm Des. 2012 Oct 18. [Epub ahead of print]
• 11. Binding of plant alkaloids berberine and palmatine to serum albumins: a thermodynamic investigation.
  Khan AY, Hossain M, Kumar GS.Mol Biol Rep. 2013 Jan;40(1):553-66. doi: 10.1007/s11033-012-2092-z. Epub 2012 Oct 12.
• 12. Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
  Brunhofer G, Fallarero A, Karlsson D, Batista-Gonzalez A, Shinde P, Gopi Mohan C, Vuorela P.Bioorg Med Chem. 2012 Nov 15;20(22):6669-79. doi: 10.1016/j.bmc.2012.09.040. Epub 2012 Sep 26.
• 13. Derivatives of the cationic plant alkaloids berberine and palmatine amplify protonophorous activity of fatty acids in model membranes and mitochondria.
  Pustovidko AV, Rokitskaya TI, Severina II, Simonyan RA, Trendeleva TA, Lyamzaev KG, Antonenko YN, Rogov AG, Zvyagilskaya RA, Skulachev VP, Chernyak BV.Mitochondrion. 2012 Sep 29. doi:pii: S1567-7249(12)00221-8.  10.1016/j.mito.2012.09.006. [Epub ahead of print]
• 14. [Study on absorption ingredients of yuanhuzhitong pill by everted intestinal sac method].
  Chen X, Zhang Y, Lin S, Yang H, Wu H, Li S, Li D, Xu H.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):2005-11. Chinese.
• 15. Synthesis and cytotoxicity evaluation of 13-n-alkyl berberine and palmatine analogues as anticancer agents.
  Zhang L, Li J, Ma F, Yao S, Li N, Wang J, Wang Y, Wang X, Yao Q.Molecules. 2012 Sep 25;17(10):11294-302.
• 16. Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy.
  Fan G, Zhang MY, Zhou XD, Lai XR, Yue QH, Tang C, Luo WZ, Zhang Y.Anal Chim Acta. 2012 Oct 17;747:76-83. doi: 10.1016/j.aca.2012.08.038. Epub 2012 Aug 30.
• 17. On-line sample concentration and determination of cationic alkaloids in human plasma by micelle to solvent stacking in capillary zone electrophoresis.
  Zhang S, Ma R, Yang X, Wang C, Wang Z.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 1;906:41-7. doi: 10.1016/j.jchromb.2012.08.017. Epub 2012 Aug 21.
• 18. Simultaneous determination of active flavonoids and alkaloids of Tang-Min-Ling-Pill in rat plasma by liquid chromatography tandem mass spectrometry.
  Zhu Y, Tong L, Zhou S, Sun H, Bi K, Zhang B.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Sep 1;904:51-8. doi: 10.1016/j.jchromb.2012.07.010. Epub 2012 Jul 20.
• 19. Discrimination of Phellodendron amurense and P. chinense based on DNA analysis and the simultaneous analysis of alkaloids.
  Ryuk JA, Zheng MS, Lee MY, Seo CS, Li Y, Lee SH, Moon DC, Lee HW, Lee JH, Park JY, Son JK, Ko BS.Arch Pharm Res. 2012 Jun;35(6):1045-54. doi: 10.1007/s12272-012-0612-y. Epub 2012 Jun 30.
• 20. Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas.
  Kim SG, Poudel A, Kim YK, Jo HK, Jung HJ.J Nat Med. 2012 Aug 2. [Epub ahead of print]

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