Botanical Ingredient

Polydatin Safety Tips

Handling of Polydatin should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Polydatin – a new mitochondria protector for acute severe hemorrhagic shock treatment.
  Wang X, Song R, Chen Y, Zhao M, Zhao KS.Expert Opin Investig Drugs. 2012 Dec 14. [Epub ahead of print]
• 2. Modulation of Human Keratinocyte Responses to Solar UV by Plant Polyphenols as a Basis for Chemoprevention of Non-Melanoma Skin Cancers.
  Kostyuk VA, Potapovich AI, Lulli D, Stancato A, De Luca C, Pastore S, Korkina L.Curr Med Chem. 2012 Dec 3. [Epub ahead of print]
• 3. Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice.
  Chen L, Lan Z, Lin Q, Mi X, He Y, Wei L, Lin Y, Zhang Y, Deng X.Food Chem Toxicol. 2012 Nov 5;52C:28-35. doi: 10.1016/j.fct.2012.10.037. [Epub ahead of print]
• 4. Analysis and Functionality of Major Polyphenolic Components of Polygonum cuspidatum (Itadori).
  Kirino A, Takasuka Y, Nishi A, Kawabe S, Yamashita H, Kimoto M, Ito H, Tsuji H.J Nutr Sci Vitaminol (Tokyo). 2012;58(4):278-86.
• 5. Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice.
  Zhang H, Yu CH, Jiang YP, Peng C, He K, Tang JY, Xin HL.PLoS One. 2012;7(9):e46574. doi: 10.1371/journal.pone.0046574. Epub 2012 Sep 28.
• 6. [Simultaneous determination of contents of five major bioactive components contained in Polygoni Cuspidati Rhizoma et Radix by microwave extraction-ultra performance liquid chromatography].
  Lu Y, Li H, Lin M, Chen D.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):1994-7. Chinese.
• 7. Polydatin (PD) inhibits IgE-mediated passive cutaneous anaphylaxis in mice by stabilizing mast cells through modulating Ca²? mobilization.
  Yuan M, Li J, Lv J, Mo X, Yang C, Chen X, Liu Z, Liu J.Toxicol Appl Pharmacol. 2012 Nov 1;264(3):462-9. doi: 10.1016/j.taap.2012.08.024. Epub 2012 Aug 30.
• 8. Polydatin, A Natural Precursor of Resveratrol, Induces β-Defensin Production and Reduces Inflammatory Response.
  Ravagnan G, De Filippis A, Cartenì M, De Maria S, Cozza V, Petrazzuolo M, Tufano MA, Donnarumma G.Inflammation. 2012 Sep 6. [Epub ahead of print]
• 9. The progress of the research on cardio-vascular effects and acting mechanism of polydatin.
  Liu LT, Guo G, Wu M, Zhang WG.Chin J Integr Med. 2012 Sep;18(9):714-9. doi: 10.1007/s11655-012-1060-8. Epub 2012 Aug 31.
• 10. Polydatin modulates Ca(2+) handling, excitation-contraction coupling, and β-adrenergic signaling in rat ventricular myocytes.
  Deng J, Liu W, Wang Y, Dong M, Zheng M, Liu J.J Mol Cell Cardiol. 2012 Nov;53(5):646-56. doi: 10.1016/j.yjmcc.2012.08.009. Epub 2012 Aug 19.
• 11. Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.
  Shi YW, Wang CP, Liu L, Liu YL, Wang X, Hong Y, Li Z, Kong LD.Mol Nutr Food Res. 2012 Sep;56(9):1433-44. doi: 10.1002/mnfr.201100828. Epub 2012 Aug 3.
• 12. Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c.
  Zhang J, Tan Y, Yao F, Zhang Q.Mol Med Report. 2012 Oct;6(4):815-20. doi: 10.3892/mmr.2012.1015. Epub 2012 Jul 31.
• 13. Polydatin Attenuates Hypoxic Pulmonary Hypertension and Reverses Remodeling through Protein Kinase C Mechanisms.
  Miao Q, Shi XP, Ye MX, Zhang J, Miao S, Wang SW, Li B, Jiang XX, Zhang S, Hu N, Li J, Zhang J.Int J Mol Sci. 2012;13(6):7776-87. doi: 10.3390/ijms13067776. Epub 2012 Jun 21.
• 14. [Effect of polydatin on expression of cdk5 in the prefrontal cortex of rats with chronic alcoholism].
  Xu CY, Li S, Hao W, Zhang RL.Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Mar;28(2):158-9, 188. Chinese.  No abstract available.
• 15. Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-κB signaling pathway in rat glomerular mesangial cells.
  Xie X, Peng J, Huang K, Huang J, Shen X, Liu P, Huang H.Mol Cell Endocrinol. 2012 Oct 15;362(1-2):183-93. doi: 10.1016/j.mce.2012.06.008. Epub 2012 Jun 22.
• 16. Multiparameter evaluation of the longevity in C. elegans under stress using an integrated microfluidic device.
  Wen H, Shi W, Qin J.Biomed Microdevices. 2012 Aug;14(4):721-8. doi: 10.1007/s10544-012-9652-9.
• 17. Polydatin protects learning and memory impairments in a rat model of vascular dementia.
  Li RP, Wang ZZ, Sun MX, Hou XL, Sun Y, Deng ZF, Xiao K.Phytomedicine. 2012 Jun 15;19(8-9):677-81. doi: 10.1016/j.phymed.2012.03.002. Epub 2012 Apr 4.
• 18. Polydatin suppresses ultraviolet B-induced cyclooxygenase-2 expression in vitro and in vivo via reduced production of reactive oxygen species.
  He YD, Liu YT, Lin QX, Zhu J, Zhang Y, Wang LY, Ren XL, Ye XY.Br J Dermatol. 2012 Oct;167(4):941-4. doi: 10.1111/j.1365-2133.2012.10951.x. Epub 2012 Jul 5. No abstract available.
• 19. Separation and identification of highly fluorescent compounds derived from trans-resveratrol in the leaves of Vitis vinifera infected by Plasmopara viticola.
  T?íska J, Vrchotová N, Olejní?ková J, Jílek R, Sotolá? R.Molecules. 2012 Mar 6;17(3):2773-83. doi: 10.3390/molecules17032773.
• 20. [Effects of polydatin on bleomycin-induced pulmonary fibrosis in rats].
  Zhang Y, Chen L, Liang B.Zhongguo Zhong Yao Za Zhi. 2011 Dec;36(24):3528-34. Chinese.

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