Botanical Ingredient

Puerarin Safety Tips

Handling of Puerarin should only be performed by personnel trained and familiar with the handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Magnetic solid-phase extraction and determination of puerarin in rat plasma using C(18)-functionalized magnetic silica nanoparticles by high performance liquid chromatography.
  Wang Q, Huang L, Yu P, Wang J, Shen S.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 23;912C:33-37. doi: 10.1016/j.jchromb.2012.11.009. [Epub ahead of print]
• 2. [Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology].
  Sun XY, Zhang YL, Zhang ZW, Luo XM.Zhong Yao Cai. 2012 Jun;35(6):980-3. Chinese.
• 3. [Determination of five components in Pueraria labta decoction with reference extraction method].
  Xue C, Zhang J, Jing W, Wang Y, Si N, Liu A.Zhongguo Zhong Yao Za Zhi. 2012 Aug;37(16):2388-91. Chinese.
• 4. Identification and assay of 3′-O-methyltaxifolin by UPLC-MS in rat plasma.
  Wang X, Zhou H, Zeng S.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Dec 12;911:34-42. doi: 10.1016/j.jchromb.2012.09.006. Epub 2012 Oct 4.
• 5. Physiochemical Properties of the Inclusion Complex of Puerarin and Glucosyl-β-Cyclodextrin.
  Liu B, Zhao J, Liu Y, Zhu X, Zeng J.J Agric Food Chem. 2012 Dec 14. [Epub ahead of print]
• 6. In vivo metabolites and plasma exposure of TongMai Keli analyzed by UHPLC/DAD/qTOF-MS and LC/MS/MS.
  Liu CF, Qiao X, Liu KD, Miao WJ, Li YJ, Liu Y, Jiang YY, Bo T, Shi RB, Guo DA, Ye M.J Ethnopharmacol. 2012 Nov 29. doi:pii: S0378-8741(12)00798-2.  10.1016/j.jep.2012.11.021. [Epub ahead of print]
• 7. HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats.
  Tao HQ, Meng Q, Li MH, Yu H, Liu MF, Du D, Sun SL, Yang HC, Wang YM, Ye W, Yang LZ, Zhu DL, Jiang CL, Peng HS.Naunyn Schmiedebergs Arch Pharmacol. 2012 Nov 29. [Epub ahead of print]
• 8. [Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury].
  Han JQ, Yu KY, He M.Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Aug;32(8):1069-72. Chinese.
• 9. Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats.
  Chen F, Zhang HQ, Zhu J, Liu KY, Cheng H, Li GL, Xu S, Lv WH, Xie ZG.Asian Pac J Trop Med. 2012 Nov;5(11):891-6. doi: 10.1016/S1995-7645(12)60166-7.
• 10. Puerarin mediates hepatoprotection against CCl(4)-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function.
  Li R, Xu L, Liang T, Li Y, Zhang S, Duan X.Food Chem Toxicol. 2012 Nov 9;52C:69-75. doi: 10.1016/j.fct.2012.10.059. [Epub ahead of print]
• 11. UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-d-glucoside and luteolin-7-O-β-d-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection.
  Yin R, Han F, Tang Z, Liu R, Zhao X, Chen X, Bi K.J Pharm Biomed Anal. 2013 Jan;72:127-33. doi: 10.1016/j.jpba.2012.09.028. Epub 2012 Oct 8.
• 12. The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice.
  Prasain JK, Peng N, Rajbhandari R, Wyss JM.Phytomedicine. 2012 Dec 15;20(1):17-23. doi: 10.1016/j.phymed.2012.09.017. Epub 2012 Nov 2.
• 13. In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity.
  Wang Y, Ma Y, Zheng Y, Song J, Yang X, Bi C, Zhang D, Zhang Q.Int J Pharm. 2012 Oct 23. doi:pii: S0378-5173(12)00961-1.  10.1016/j.ijpharm.2012.10.021. [Epub ahead of print]
• 14. Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway.
  Zou Y, Hong B, Fan L, Zhou L, Liu Y, Wu Q, Zhang X, Dong M.Free Radic Res. 2013 Jan;47(1):55-63. doi: 10.3109/10715762.2012.742518. Epub 2012 Nov 15.
• 15. Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model.
  Liang XL, Zhao LJ, Liao ZG, Zhao GW, Zhang J, Chao YC, Yang M, Yin RL.J Ethnopharmacol. 2012 Dec 18;144(3):677-82. doi: 10.1016/j.jep.2012.10.011. Epub 2012 Oct 23.
• 16. Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice.
  Sheu SY, Tsai CC, Sun JS, Chen MH, Liu MH, Sun MG.Chin Med J (Engl). 2012 Oct;125(20):3646-53.
• 17. Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors.
  Zhang J, Li X, Gao Y, Guo G, Xu C, Li G, Liu S, Huang A, Tu G, Peng H, Qiu S, Fan B, Zhu Q, Yu S, Zheng C, Liang S.Burns. 2012 Oct 5. doi:pii: S0305-4179(12)00262-8.  10.1016/j.burns.2012.08.013. [Epub ahead of print]
• 18. Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ß-estradiol-BSA.
  Cheng W, Chen L, Yang S, Han J, Zhai D, Ni J, Yu C, Cai Z.PLoS One. 2012;7(9):e45529. doi: 10.1371/journal.pone.0045529. Epub 2012 Sep 19.
• 19. [Distribution of puerarin contained in Zige freeze-dried powder injection in rat liver and kidney].
  Wang Q, Xing M, Deng L, Wang Y, Mukaram K, Xu X.Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1677-81. Chinese.
• 20. Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology.
  Fan JP, Cao J, Zhang XH, Huang JZ, Kong T, Tong S, Tian ZY, Xie YL, Xu R, Zhu JH.Food Chem. 2012 Dec 15;135(4):2299-306. doi: 10.1016/j.foodchem.2012.07.038. Epub 2012 Jul 15.

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