Botanical Ingredient

Punicalagin Safety Tips

Handling of Punicalagin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Sustained deficit irrigation affects the colour and phytochemical characteristics of pomegranate juice.
  Mena P, Galindo A, Collado-González J, Ondoño S, García-Viguera C, Ferreres F, Torrecillas A, Gil-Izquierdo A.J Sci Food Agric. 2012 Nov 16. doi: 10.1002/jsfa.5991. [Epub ahead of print]
• 2. Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo.
  Yang Y, Xiu J, Zhang L, Qin C, Liu J.Phytomedicine. 2012 Dec 15;20(1):67-70. doi: 10.1016/j.phymed.2012.08.012. Epub 2012 Nov 10.
• 3. Pomegranate phytosterol (β-sitosterol) and polyphenolic antioxidant (punicalagin) addition to statin, significantly protected against macrophage foam cells formation.
  Rosenblat M, Volkova N, Aviram M.Atherosclerosis. 2012 Oct 31. doi:pii: S0021-9150(12)00740-X.  10.1016/j.atherosclerosis.2012.10.054. [Epub ahead of print]
• 4. Storage stability of sterilized liquid extracts from pomegranate peel.
  Qu W, Breksa Iii AP, Pan Z, Ma H, McHugh TH.J Food Sci. 2012 Jul;77(7):C765-72. doi: 10.1111/j.1750-3841.2012.02779.x.
• 5. Anti-inflammatory effects of pomegranate (Punica granatum L.) husk ellagitannins in Caco-2 cells, an in vitro model of human intestine.
  Hollebeeck S, Winand J, Hérent MF, During A, Leclercq J, Larondelle Y, Schneider YJ.Food Funct. 2012 Aug;3(8):875-85. doi: 10.1039/c2fo10258g. Epub 2012 Jun 26.
• 6. Inhibition of melanin production by a combination of Siberian larch and pomegranate fruit extracts.
  Diwakar G, Rana J, Scholten JD.Fitoterapia. 2012 Sep;83(6):989-95. doi: 10.1016/j.fitote.2012.06.004. Epub 2012 Jun 17.
• 7. Pomegranate materials inhibit flagellin gene expression and flagellar-propelled motility of uropathogenic Escherichia coli strain CFT073.
  Asadishad B, Hidalgo G, Tufenkji N.FEMS Microbiol Lett. 2012 Sep;334(2):87-94. doi: 10.1111/j.1574-6968.2012.02622.x. Epub 2012 Jul 12.
• 8. Pomegranate Ellagitannins.
  Heber D.In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press; 2011. Chapter 10.
• 9. Partial identification of antifungal compounds from Punica granatum peel extracts.
  Glazer I, Masaphy S, Marciano P, Bar-Ilan I, Holland D, Kerem Z, Amir R.J Agric Food Chem. 2012 May 16;60(19):4841-8. doi: 10.1021/jf300330y. Epub 2012 May 7.
• 10. Anti-Helicobacter pylori activity of Terminalia macroptera root.
  Silva O, Viegas S, de Mello-Sampayo C, Costa MJ, Serrano R, Cabrita J, Gomes ET.Fitoterapia. 2012 Jul;83(5):872-6. doi: 10.1016/j.fitote.2012.03.019. Epub 2012 Mar 21.
• 11. Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and human placental trophoblasts.
  Chen B, Tuuli MG, Longtine MS, Shin JS, Lawrence R, Inder T, Michael Nelson D.Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1142-52. doi: 10.1152/ajpendo.00003.2012. Epub 2012 Feb 28.
• 12. Punicalagin and catechins contain polyphenolic substructures that influence cell viability and can be monitored by radical chemosensors sensitive to electron transfer.
  Carreras A, Mateos-Martín ML, Velázquez-Palenzuela A, Brillas E, Sánchez-Tena S, Cascante M, Juliá L, Torres JL.J Agric Food Chem. 2012 Feb 22;60(7):1659-65. doi: 10.1021/jf204059x. Epub 2012 Feb 10. Erratum in: J Agric Food Chem. 2012 May 9;60(18):4763. Sánchez-Tena, Susana [added].
• 13. Enhanced activity of punicalagin delivered via polymeric implants against benzo[a]pyrene-induced DNA adducts.
  Aqil F, Vadhanam MV, Gupta RC.Mutat Res. 2012 Mar 18;743(1-2):59-66. doi: 10.1016/j.mrgentox.2011.12.022. Epub 2012 Jan 5.
• 14. Simple solution for a complex problem: proanthocyanidins, galloyl glucoses and ellagitannins fit on a single calibration curve in high performance-gel permeation chromatography.
  Stringano E, Gea A, Salminen JP, Mueller-Harvey I.J Chromatogr A. 2011 Oct 28;1218(43):7804-12. doi: 10.1016/j.chroma.2011.08.082. Epub 2011 Sep 3.
• 15. The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates β-cell insulin release.
  Koren-Gluzer M, Aviram M, Meilin E, Hayek T.Atherosclerosis. 2011 Dec;219(2):510-8. doi: 10.1016/j.atherosclerosis.2011.07.119. Epub 2011 Aug 4.
• 16. Paraoxonase 1 (PON1) inhibits monocyte-to-macrophage differentiation.
  Rosenblat M, Volkova N, Ward J, Aviram M.Atherosclerosis. 2011 Nov;219(1):49-56. doi: 10.1016/j.atherosclerosis.2011.06.054. Epub 2011 Jul 12.
• 17. Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD-ESI/MS(n).
  Fischer UA, Carle R, Kammerer DR.Food Chem. 2011 Jul 15;127(2):807-21. doi: 10.1016/j.foodchem.2010.12.156. Epub 2011 Jan 11.
• 18. Effects of mass ratio, pH, temperature, and reaction time on fabrication of partially purified pomegranate ellagitannin-gelatin nanoparticles.
  Li Z, Gu L.J Agric Food Chem. 2011 Apr 27;59(8):4225-31. doi: 10.1021/jf200024d. Epub 2011 Mar 21.
• 19. The swarming motility of Pseudomonas aeruginosa is blocked by cranberry proanthocyanidins and other tannin-containing materials.
  O’May C, Tufenkji N.Appl Environ Microbiol. 2011 May;77(9):3061-7. doi: 10.1128/AEM.02677-10. Epub 2011 Mar 4.
• 20. Fabrication of nanoparticles using partially purified pomegranate ellagitannins and gelatin and their apoptotic effects.
  Li Z, Percival SS, Bonard S, Gu L.Mol Nutr Food Res. 2011 Jul;55(7):1096-103. doi: 10.1002/mnfr.201000528. Epub 2011 Mar 4.

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