Botanical Ingredient

Rhein Safety Tips

Handling of Rhein should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Validated Stability Indicating TLC-Densitometric Method for the Determination of Diacerein.
  Ali NW, Abdelwahab NS, Abdelkawy M, Emam AA.J Chromatogr Sci. 2012 Dec 20. [Epub ahead of print]
• 2. A monoclonal antibody against bovine adiponectin.
  Raffelsieper M, Mielenz B, Häußler S, Sauerwein H, Mielenz M, Illges H.Hybridoma (Larchmt). 2012 Dec;31(6):465-8. doi: 10.1089/hyb.2012.0054.
• 3. Cutoff Values for Alcoholic Liver Fibrosis Using Magnetic Resonance Elastography Technique.
  Bensamoun SF, Leclerc GE, Debernard L, Cheng X, Robert L, Charleux F, Rhein C, Latrive JP.Alcohol Clin Exp Res. 2012 Dec 6. doi: 10.1111/acer.12025. [Epub ahead of print]
• 4. Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats.
  Cheng YS, Cong XD, Dai DZ, Zhang Y, Dai Y.J Pharm Pharmacol. 2013 Jan;65(1):94-101. doi: 10.1111/j.2042-7158.2012.01565.x. Epub 2012 Jul 24.
• 5. The Influence of Rhein 8-O-β-D-Glucopyranoside on the Purgative Action of Sennoside A from Rhubarb in Mice.
  Takayama K, Tsutsumi H, Ishizu T, Okamura N.Biol Pharm Bull. 2012;35(12):2204-8.
• 6. Reflections on my Family History, my Youth, and my Professional Career.
  Zu Rhein GM.J Neuropathol Exp Neurol. 2012 Dec;71(12):1149-62. doi: 10.1097/NEN.0b013e318279f4a0.
• 7. Comparative Pharmacokinetics of Five Rhubarb Anthraquinones in Normal and Thrombotic Focal Cerebral Ischemia-Induced Rats.
  Feng SX, Li JS, Qu LB, Shi YM, Zhao D.Phytother Res. 2012 Nov 26. doi: 10.1002/ptr.4890. [Epub ahead of print]
• 8. Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats.
  Wang Z, Hu H, Chen F, Lan K, Wang A.J Ethnopharmacol. 2012 Nov 16. doi:pii: S0378-8741(12)00769-6.  10.1016/j.jep.2012.11.008. [Epub ahead of print]
• 9. Anti-inflammatory activity of a novel family of aryl ureas compounds in an endotoxin-induced airway epithelial cell injury model.
  Cabrera-Benitez NE, Pérez-Roth E, Casula M, Ramos-Nuez A, Ríos-Luci C, Rodríguez-Gallego C, Sologuren I, Jakubkiene V, Slutsky AS, Padrón JM, Villar J.PLoS One. 2012;7(11):e48468. doi: 10.1371/journal.pone.0048468. Epub 2012 Nov 8.
• 10. Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1 Upregulation in Brown Adipose Tissue.
  Sheng X, Zhu X, Zhang Y, Cui G, Peng L, Lu X, Zang YQ.Int J Biol Sci. 2012;8(10):1375-84. doi: 10.7150/ijbs.4575. Epub 2012 Oct 29.
• 11. Effect of acute pancreatitis on the pharmacokinetics of Chinese herbal ointment Liu-He-Dan in anaesthetized rats.
  Zhao XL, Xiang J, Wan MH, Yu Q, Chen WW, Chen GY, Tang WF.J Ethnopharmacol. 2012 Nov 2. doi:pii: S0378-8741(12)00733-7.  10.1016/j.jep.2012.10.036. [Epub ahead of print]
• 12. Toxicology and Carcinogenesis Study of Senna in C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice.
  Surh I, Brix A, French JE, Collins BJ, Sanders JM, Vallant M, Dunnick JK.Toxicol Pathol. 2012 Nov 2. [Epub ahead of print]
• 13. Study on Spectrum-Effect Relationship of Rhizoma Rhei, Cortex Magnoliae Officinalis, Fructus Aurantii Immaturus and their Formula.
  Xie RF, Zhou X, Shi ZN, Li YM, Li ZC.J Chromatogr Sci. 2012 Oct 31. [Epub ahead of print]
• 14. Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate.
  Suneela D, Dipmala P.Bioorg Med Chem Lett. 2012 Dec 15;22(24):7582-7. doi: 10.1016/j.bmcl.2012.10.017. Epub 2012 Oct 11.
• 15. Linking systemic angiogenic factors (VEGF, angiogenin, TIMP-2) and Doppler ultrasound to anti-inflammatory treatment in rheumatoid arthritis.
  Strunk J, Rumbaur C, Albrecht K, Neumann E, Müller-Ladner U.Joint Bone Spine. 2012 Oct 22. doi:pii: S1297-319X(12)00206-0.  10.1016/j.jbspin.2012.09.001. [Epub ahead of print]
• 16. Efficacy of Psychosocial Interventions in Men and Women with Sexual Dysfunctions-A Systematic Review of Controlled Clinical Trials: Part 1-The efficacy of psychosocial interventions for male sexual dysfunction.
  Berner M, Günzler C.J Sex Med. 2012 Dec;9(12):3089-107. doi: 10.1111/j.1743-6109.2012.02970.x. Epub 2012 Oct 22.
• 17. Efficacy of psychosocial interventions in men and women with sexual dysfunctions-a systematic review of controlled clinical trials: part 2-the efficacy of psychosocial interventions for female sexual dysfunction.
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• 18. Compounded pimobendan for canine chronic degenerative mitral valve disease and pulmonary hypertension.
  Helms SR, Fox S, Mixon W, Vail J.Int J Pharm Compd. 2012 Jan-Feb;16(1):34-41.
• 19. Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling.
  Zhang Y, Fan S, Hu N, Gu M, Chu C, Li Y, Lu X, Huang C.PPAR Res. 2012;2012:374936. doi: 10.1155/2012/374936. Epub 2012 Sep 25.
• 20. Development of Cell-Active N(6)-Methyladenosine RNA Demethylase FTO Inhibitor.
  Chen B, Ye F, Yu L, Jia G, Huang X, Zhang X, Peng S, Chen K, Wang M, Gong S, Zhang R, Yin J, Li H, Yang Y, Liu H, Zhang J, Zhang H, Zhang A, Jiang H, Luo C, Yang CG.J Am Chem Soc. 2012 Oct 31;134(43):17963-71. doi: 10.1021/ja3064149. Epub 2012 Oct 17.

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