Botanical Ingredient

Yohimbine HCl Safety Tips

Handling of Yohimbine HCl should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Stimulation of the noradrenergic system during memory formation impairs extinction learning but not the disruption of reconsolidation.
  Soeter M, Kindt M.Neuropsychopharmacology. 2012 Apr;37(5):1204-15. doi: 10.1038/npp.2011.307. Epub 2011 Dec 14.
• 2. Antinociceptive and antihyperalgesic effects of tapentadol in animal models of inflammatory pain.
  Schiene K, De Vry J, Tzschentke TM.J Pharmacol Exp Ther. 2011 Nov;339(2):537-44. doi: 10.1124/jpet.111.181263. Epub 2011 Aug 4.
• 3. Noradrenergic enhancement of associative fear memory in humans.
  Soeter M, Kindt M.Neurobiol Learn Mem. 2011 Sep;96(2):263-71. doi: 10.1016/j.nlm.2011.05.003. Epub 2011 May 23.
• 4. (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties.
  Tzschentke TM, Christoph T, Kögel B, Schiene K, Hennies HH, Englberger W, Haurand M, Jahnel U, Cremers TI, Friderichs E, De Vry J.J Pharmacol Exp Ther. 2007 Oct;323(1):265-76. Epub 2007 Jul 26.
• 5. The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation.
  Gajewski Z, Thun R, Faundez R, Pawlinski B.J Physiol Pharmacol. 2006 Nov;57 Suppl 8:173-88.
• 6. Adrenergic stimulation and blocking of hormonal secretion activity of cultured cow granulosa cells.
  Gajewski Z, Faundez R, Thun R, Pawlinski B.J Physiol Pharmacol. 2006 Nov;57 Suppl 8:125-37.
• 7. Biphasic effects of losartan potassium on immobility in mice.
  Vijayapandi P, Nagappa AN.Yakugaku Zasshi. 2005 Aug;125(8):653-7.
• 8. Spectrophotometric determination of Rauwolfia alkaloids: estimation of reserpine in pharmaceuticals.
  Singh DK, Srivastava B, Sahu A.Anal Sci. 2004 Mar;20(3):571-3.
• 9. The effects of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder.
  Meston CM, Worcel M.Arch Sex Behav. 2002 Aug;31(4):323-32.
• 10. (-)-1-(Benzofuran-2-yl)-2-propylaminopentane enhances locomotor activity in rats due to its ability to induce dopamine release.
  Shimazu S, Takahata K, Katsuki H, Tsunekawa H, Tanigawa A, Yoneda F, Knoll J, Akaike A.Eur J Pharmacol. 2001 Jun 15;421(3):181-9.
• 11. Anesthesia in female white-tailed deer using Telazol and xylazine.
  Murray S, Monfort SL, Ware L, McShea WJ, Bush M.J Wildl Dis. 2000 Oct;36(4):670-5.
• 12. A high-performance liquid chromatography assay for yohimbine HCl analysis.
  Mittal S, Alexander KS, Dollimore D.Drug Dev Ind Pharm. 2000 Oct;26(10):1059-65.
• 13. In vivo characterization of novel full and partial 2-(4-aminophenyl)-N,N-dipropylethylamine dopamine D(2) receptor agonists.
  Ahlenius S, Ericson E, Florvall L, Jiménez P, Hillegaart V, Wijkström A.Eur J Pharmacol. 2000 Apr 14;394(2-3):247-53.
• 14. Immobilization of babirusa (Babyrousa babyrussa) with xylazine and tiletamine/zolazepam and reversal with yohimbine and flumazenil.
  James SB, Cook RA, Raphael BL, Stetter MD, Kalk P, MacLaughlin K, Calle PP.J Zoo Wildl Med. 1999 Dec;30(4):521-5.
• 15. Hypercapnia-induced long-term depression of respiratory activity requires alpha2-adrenergic receptors.
  Bach KB, Mitchell GS.J Appl Physiol. 1998 Jun;84(6):2099-105.
• 16. Development and characterization of an equine behaviour chamber and the effects of amitraz and detomidine on spontaneous locomotor activity.
  Harkins JD, Queiroz-Neto A, Mundy GD, West D, Tobin T.J Vet Pharmacol Ther. 1997 Oct;20(5):396-401.
• 17. Immobilization of domestic goats (Capra hircus) using orally administered carfentanil citrate and detomidine hydrochloride.
  Sleeman JM, Carter W, Tobin T, Ramsay EC.J Zoo Wildl Med. 1997 Jun;28(2):158-65.
• 18. Neural responses to bitter compounds in rats.
  Dahl M, Erickson RP, Simon SA.Brain Res. 1997 May 9;756(1-2):22-34.
• 19. Potentiation of acetaminophen hepatotoxicity by acute physical exercise in rats.
  Yoon MY, Kim SN, Kim YC.Res Commun Mol Pathol Pharmacol. 1997 Apr;96(1):35-44.
• 20. Effect of vitamin E and selenium on hypothermic restraint stress and chemically-induced ulcers.
  al-Moutairy AR, Tariq M.Dig Dis Sci. 1996 Jun;41(6):1165-71.

Details