Standard Herbal Extract

Boswellia Serrata Extract Safety Tips

Handling of Boswellia Serrata Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome®) of Boswellia extract.
  Hüsch J, Bohnet J, Fricker G, Skarke C, Artaria C, Appendino G, Schubert-Zsilavecz M, Abdel-Tawab M.Fitoterapia. 2012 Oct 23;84C:89-98. doi: 10.1016/j.fitote.2012.10.002. [Epub ahead of print]
• 2. Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.
  Hüsch J, Gerbeth K, Fricker G, Setzer C, Zirkel J, Rebmann H, Schubert-Zsilavecz M, Abdel-Tawab M.J Nat Prod. 2012 Oct 26;75(10):1675-82. doi: 10.1021/np300009w. Epub 2012 Sep 26.
• 3. Safety Evaluation of Alcoholic Extract of Boswellia ovalifoliolata Stem-bark in Rats.
  Devi PR, Adilaxmamma K, Rao GS, Srilatha Ch, Raj MA.Toxicol Int. 2012 May;19(2):115-20. doi: 10.4103/0971-6580.97198.
• 4. Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid.
  Hartmann RM, Morgan Martins MI, Tieppo J, Fillmann HS, Marroni NP.Dig Dis Sci. 2012 Aug;57(8):2038-44. doi: 10.1007/s10620-012-2134-3. Epub 2012 Mar 27.
• 5. Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii.
  Su S, Hua Y, Wang Y, Gu W, Zhou W, Duan JA, Jiang H, Chen T, Tang Y.J Ethnopharmacol. 2012 Jan 31;139(2):649-56. doi: 10.1016/j.jep.2011.12.013. Epub 2011 Dec 13.
• 6. A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee.
  Vishal AA, Mishra A, Raychaudhuri SP.Int J Med Sci. 2011;8(7):615-22. Epub 2011 Oct 12.
• 7. Effect of a Herbal-Leucine mix on the IL-1β-induced cartilage degradation and inflammatory gene expression in human chondrocytes.
  Akhtar N, Miller MJ, Haqqi TM.BMC Complement Altern Med. 2011 Aug 19;11:66. doi: 10.1186/1472-6882-11-66.
• 8. Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE).
  Shehata AM, Quintanilla-Fend L, Bettio S, Singh CB, Ammon HP.Phytomedicine. 2011 Sep 15;18(12):1037-44. doi: 10.1016/j.phymed.2011.06.035. Epub 2011 Aug 9.
• 9. Anti-inflammatory, antinociceptive and antioxidant activities of the endemic Soqotraen Boswellia elongata Balf. f. and Jatropha unicostata Balf. f. in different experimental models.
  Mothana RA.Food Chem Toxicol. 2011 Oct;49(10):2594-9. doi: 10.1016/j.fct.2011.06.079. Epub 2011 Jul 14.
• 10. Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation.
  Kokkiripati PK, Bhakshu LM, Marri S, Padmasree K, Row AT, Raghavendra AS, Tetali SD.J Ethnopharmacol. 2011 Sep 1;137(1):893-901. doi: 10.1016/j.jep.2011.07.004. Epub 2011 Jul 8.
• 11. Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data.
  Abdel-Tawab M, Werz O, Schubert-Zsilavecz M.Clin Pharmacokinet. 2011 Jun;50(6):349-69. doi: 10.2165/11586800-000000000-00000. Review.
• 12. Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats.
  Mahmoudi A, Hosseini-Sharifabad A, Monsef-Esfahani HR, Yazdinejad AR, Khanavi M, Roghani A, Beyer C, Sharifzadeh M.J Nat Med. 2011 Jul;65(3-4):519-25. doi: 10.1007/s11418-011-0533-y. Epub 2011 Apr 11.
• 13. Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.
  Sengupta K, Kolla JN, Krishnaraju AV, Yalamanchili N, Rao CV, Golakoti T, Raychaudhuri S, Raychaudhuri SP.Mol Cell Biochem. 2011 Aug;354(1-2):189-97. doi: 10.1007/s11010-011-0818-1. Epub 2011 Apr 11.
• 14. The effect of Frankincense in the treatment of moderate plaque-induced gingivitis: a double blinded randomized clinical trial.
  Khosravi Samani M, Mahmoodian H, Moghadamnia A, Poorsattar Bejeh Mir A, Chitsazan M.Daru. 2011;19(4):288-94.
• 15. Anticholinesterase activity of endemic plant extracts from Soqotra.
  Bakthira H, Awadh Ali NA, Arnold N, Teichert A, Wessjohann L.Afr J Tradit Complement Altern Med. 2011;8(3):296-9. Epub 2011 Apr 2.
• 16. Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity.
  Schmidt TJ, Kaiser M, Brun R.Planta Med. 2011 May;77(8):849-50. doi: 10.1055/s-0030-1250612. Epub 2010 Dec 14.
• 17. Randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohn’s disease: good safety profile but lack of efficacy.
  Holtmeier W, Zeuzem S, Preiss J, Kruis W, Böhm S, Maaser C, Raedler A, Schmidt C, Schnitker J, Schwarz J, Zeitz M, Caspary W.Inflamm Bowel Dis. 2011 Feb;17(2):573-82. doi: 10.1002/ibd.21345.
• 18. Modulation of the immune system by Boswellia serrata extracts and boswellic acids.
  Ammon HP.Phytomedicine. 2010 Sep;17(11):862-7. doi: 10.1016/j.phymed.2010.03.003. Epub 2010 Aug 8. Review. Erratum in: Phytomedicine. 2011 Feb 15;18(4):334.
• 19. Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma.
  Houssen ME, Ragab A, Mesbah A, El-Samanoudy AZ, Othman G, Moustafa AF, Badria FA.Clin Biochem. 2010 Jul;43(10-11):887-90. doi: 10.1016/j.clinbiochem.2010.04.061. Epub 2010 Apr 27.
• 20. Mutagenicity evaluation with Ames test of hydro-alcoholic solution of terpenes.
  Lupi S, Marconi S, Paiaro E, Fochesato A, Gregorio P.J Prev Med Hyg. 2009 Sep;50(3):170-4.