Standard Herbal Extract

Capsicum Annuum Extract Safety Tips

Handling of Capsicum Annuum Extract should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Japanese Butterbur (Petasites japonicus) Leaves Increase Hepatic Oxidative Stress in Male Rats.
  Han KH, Sekikawa M, Shimada K, Lee CH, Hashimoto N, Fukushima M.Biosci Biotechnol Biochem. 2012 Nov 23;76(11):2026-31. Epub 2012 Nov 7.
• 2. Nonpharmacologic treatments for migraine and tension-type headache: how to choose and when to use.
  Nicholson RA, Buse DC, Andrasik F, Lipton RB.Curr Treat Options Neurol. 2011 Feb;13(1):28-40. doi: 10.1007/s11940-010-0102-9.
• 3. Suppressive effect of Petasites japonicus extract on ovalbumin-induced airway inflammation in an asthmatic mouse model.
  Lee JS, Yang EJ, Yun CY, Kim DH, Kim IS.J Ethnopharmacol. 2011 Jan 27;133(2):551-7. doi: 10.1016/j.jep.2010.10.038. Epub 2010 Oct 26.
• 4. Butterbur (Petasites japonicus Max.) extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice.
  Park CH, Kim MY, Sok DE, Kim JH, Lee JH, Kim MR.J Med Food. 2010 Oct;13(5):1216-23. doi: 10.1089/jmf.2009.1380.
• 5. Suppression of murine preadipocyte differentiation and reduction of visceral fat accumulation by a Petasites japonicus ethanol extract in mice fed a high-fat diet.
  Watanabe T, Hata K, Hiwatashi K, Hori K, Suzuki N, Itoh H.Biosci Biotechnol Biochem. 2010;74(3):499-503. Epub 2010 Mar 7.
• 6. Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves.
  Kang HG, Jeong SH, Cho JH.J Vet Sci. 2010 Mar;11(1):51-8.
• 7. Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice.
  Brattström A, Schapowal A, Maillet I, Schnyder B, Ryffel B, Moser R.Phytother Res. 2010 May;24(5):680-5. doi: 10.1002/ptr.2972.
• 8. Toxicogenomics applied to cultures of human hepatocytes enabled an identification of novel petasites hybridus extracts for the treatment of migraine with improved hepatobiliary safety.
  Anderson N, Meier T, Borlak J.Toxicol Sci. 2009 Dec;112(2):507-20. doi: 10.1093/toxsci/kfp216. Epub 2009 Sep 21.
• 9. Use-dependent block of voltage-gated Cav2.1 Ca2+ channels by petasins and eudesmol isomers.
  Horak S, Koschak A, Stuppner H, Striessnig J.J Pharmacol Exp Ther. 2009 Jul;330(1):220-6. doi: 10.1124/jpet.109.151183. Epub 2009 Apr 15.
• 10. Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities.
  Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.Planta Med. 2009 Feb;75(3):230-5. doi: 10.1055/s-0028-1088377. Epub 2008 Dec 15.
• 11. Herbal medicines for the treatment of allergic rhinitis: a systematic review.
  Guo R, Pittler MH, Ernst E.Ann Allergy Asthma Immunol. 2007 Dec;99(6):483-95. doi: 10.1016/S1081-1206(10)60375-4. Review.
• 12. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study.
  Oelkers-Ax R, Leins A, Parzer P, Hillecke T, Bolay HV, Fischer J, Bender S, Hermanns U, Resch F.Eur J Pain. 2008 Apr;12(3):301-13. Epub 2007 Jul 30.
• 13. Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review.
  Agosti R, Duke RK, Chrubasik JE, Chrubasik S.Phytomedicine. 2006 Nov;13(9-10):743-6. Epub 2006 Sep 20. Review.
• 14. The butterbur extract petasin has no effect on skin test reactivity induced by different stimuli: a randomized, double-blind crossover study using histamine, codeine, methacholine, and aeroallergen solutions.
  Gex-Collet C, Imhof L, Brattström A, Pichler WJ, Helbling A.J Investig Allergol Clin Immunol. 2006;16(3):156-61.
• 15. Efficacy and safety of butterbur herbal extract Ze 339 in seasonal allergic rhinitis: postmarketing surveillance study.
  Käufeler R, Polasek W, Brattström A, Koetter U.Adv Ther. 2006 Mar-Apr;23(2):373-84.
• 16. Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients.
  Shimoda H, Tanaka J, Yamada E, Morikawa T, Kasajima N, Yoshikawa M.J Agric Food Chem. 2006 Apr 19;54(8):2915-20.
• 17. Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid.
  Cui HS, Kim MR, Sok DE.J Agric Food Chem. 2005 Nov 2;53(22):8526-32.
• 18. A new furofuran lignan with antioxidant and antiseizure activities from the leaves of Petasites japonicus.
  Min BS, Cui HS, Lee HK, Sok DE, Kim MR.Arch Pharm Res. 2005 Sep;28(9):1023-6.
• 19. Neuroprotective effects of butterbur and rough aster against kainic Acid-induced oxidative stress in mice.
  Oh SH, Sok DE, Kim MR.J Med Food. 2005 Summer;8(2):169-76.
• 20. Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339.
  Schapowal A; Study Group.Phytother Res. 2005 Jun;19(6):530-7.

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