Standard Herbal Extract

Celery Seed Extract Safety Tips

Handling of Celery Seed Extract should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Modulation of multidrug resistance in cancer cells by chelidonine and Chelidonium majus alkaloids.
  El-Readi MZ, Eid S, Ashour ML, Tahrani A, Wink M.Phytomedicine. 2012 Dec 10. doi:pii: S0944-7113(12)00408-4.  10.1016/j.phymed.2012.11.005. [Epub ahead of print]
• 2. Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K/AKT signalling pathways.
  Paul A, Bishayee K, Ghosh S, Mukherjee A, Sikdar S, Chakraborty D, Boujedaini N, Khuda-Bukhsh AR.Zhong Xi Yi Jie He Xue Bao. 2012 Sep;10(9):1025-38.
• 3. Chelidonium majus leaves methanol extract and its chelidonine alkaloid ingredient reduce cadmium-induced nephrotoxicity in rats.
  Koriem KM, Arbid MS, Asaad GF.J Nat Med. 2013 Jan;67(1):159-67. doi: 10.1007/s11418-012-0667-6. Epub 2012 Apr 8.
• 4. Inhibitory effects of Chelidonium majus extract on atopic dermatitis-like skin lesions in NC/Nga mice.
  Yang G, Lee K, Lee MH, Kim SH, Ham IH, Choi HY.J Ethnopharmacol. 2011 Nov 18;138(2):398-403. doi: 10.1016/j.jep.2011.09.028. Epub 2011 Sep 22.
• 5. Capillary electrophoresis with LED-induced native fluorescence detection for determination of isoquinoline alkaloids and their cytotoxicity in extracts of Chelidonium majus L.
  Kulp M, Bragina O, Kogerman P, Kaljurand M.J Chromatogr A. 2011 Aug 5;1218(31):5298-304. doi: 10.1016/j.chroma.2011.06.016. Epub 2011 Jun 17.
• 6. In vitro activity of plant extracts and alkaloids against clinical isolates of extended-spectrum β-lactamase (ESBL)-producing strains.
  Zuo GY, Meng FY, Han J, Hao XY, Wang GC, Zhang YL, Zhang Q.Molecules. 2011 Jun 28;16(7):5453-9. doi: 10.3390/molecules16075453.
• 7. In vivo anthelmintic activity of chelidonine from Chelidonium majus L. against Dactylogyrus intermedius in Carassius auratus.
  Yao JY, Zhou ZM, Pan XY, Hao GJ, Li XL, Xu Y, Shen JY, Ru HS, Yin WL.Parasitol Res. 2011 Nov;109(5):1465-9. doi: 10.1007/s00436-011-2416-2. Epub 2011 May 3.
• 8. Activity of the chelerythrine, a quaternary benzo[c]phenanthridine alkaloid from Chelidonium majus L. on Dactylogyrus intermedius.
  Li XL, Yao JY, Zhou ZM, Shen JY, Ru HS, Liu XL.Parasitol Res. 2011 Jul;109(1):247-52. doi: 10.1007/s00436-011-2320-9. Epub 2011 Mar 12.
• 9. Microarray analysis of the chelerythrine-induced transcriptome of Mycobacterium tuberculosis.
  Liang J, Zeng F, Guo A, Liu L, Guo N, Li L, Jin J, Wu X, Liu M, Zhao D, Li Y, Jin Q, Yu L.Curr Microbiol. 2011 Apr;62(4):1200-8. doi: 10.1007/s00284-010-9837-5. Epub 2010 Dec 19.
• 10. Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment.
  Mazzanti G, Di Sotto A, Franchitto A, Mammola CL, Mariani P, Mastrangelo S, Menniti-Ippolito F, Vitalone A.J Ethnopharmacol. 2009 Dec 10;126(3):518-24. doi: 10.1016/j.jep.2009.09.004. Epub 2009 Sep 15.
• 11. [Antitumor activity of the plant remedy peptide extract PE-PM in a new mouse T-lymphoma/eukemia model].
  Chaadaeva AV, Tenkeeva II, Moiseeva EV, Svirshchevskaia EV, Demushkin VP.Biomed Khim. 2009 Jan-Feb;55(1):81-8. Russian.
• 12. Antibacterial alkaloids from chelidonium majus linn (papaveraceae) against clinical isolates of methicillin-resistant Staphylococcus aureus.
  Zuo GY, Meng FY, Hao XY, Zhang YL, Wang GC, Xu GL.J Pharm Pharm Sci. 2008;11(4):90-4.
• 13. SPR in drug discovery: searching bioactive compounds in plant extracts.
  Minunni M, Bilia AR.Methods Mol Biol. 2009;572:203-18. doi: 10.1007/978-1-60761-244-5_13.
• 14. Potential antioxidant activity, cytotoxic and apoptosis-inducing effects of Chelidonium majus L. extract on leukemia cells.
  Nadova S, Miadokova E, Alfoldiova L, Kopaskova M, Hasplova K, Hudecova A, Vaculcikova D, Gregan F, Cipak L.Neuro Endocrinol Lett. 2008 Oct;29(5):649-52.
• 15. An optical DNA-based biosensor for the analysis of bioactive constituents with application in drug and herbal drug screening.
  Minunni M, Tombelli S, Mascini M, Bilia A, Bergonzi MC, Vincieri FF.Talanta. 2005 Jan 30;65(2):578-85. doi: 10.1016/j.talanta.2004.07.020.
• 16. Efficacy of a plant extract (Chelidonium majus L.) in combating induced hepatocarcinogenesis in mice.
  Biswas SJ, Bhattacharjee N, Khuda-Bukhsh AR.Food Chem Toxicol. 2008 May;46(5):1474-87. doi: 10.1016/j.fct.2007.12.009. Epub 2007 Dec 15.
• 17. Effects of aqueous extracts from five species of the family Papaveraceae on selected aquatic organisms.
  Jancula D, Suchomelová J, Gregor J, Smutná M, Marsálek B, Táborská E.Environ Toxicol. 2007 Oct;22(5):480-6.
• 18. Proteomic analysis of Chelidonium majus milky sap using two-dimensional gel electrophoresis and tandem mass spectrometry.
  Nawrot R, Kalinowski A, Gozdzicka-Jozefiak A.Phytochemistry. 2007 Jun;68(12):1612-22. Epub 2007 May 18.
• 19. Suppressive effects of Chelidonium majus methanol extract in knee joint, regional lymph nodes, and spleen on collagen-induced arthritis in mice.
  Lee YC, Kim SH, Roh SS, Choi HY, Seo YB.J Ethnopharmacol. 2007 May 30;112(1):40-8. Epub 2007 Feb 2.
• 20. Virucidal agents in the eve of manorapid synergy.
  Galabov AS.GMS Krankenhhyg Interdiszip. 2007 Sep 13;2(1):Doc18.

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