Standard Herbal Extract

Ginseng Root (American) Extract Safety Tips

Handling of Ginseng Root (American) Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Ginseng and Its Active Components Ginsenosides Inhibit Adipogenesis in 3T3-L1 Cells by Regulating MMP-2 and MMP-9.
  Oh J, Lee H, Park D, Ahn J, Shin SS, Yoon M.Evid Based Complement Alternat Med. 2012;2012:265023. doi: 10.1155/2012/265023. Epub 2012 Nov 14.
• 2. Bioactivity and Bioavailability of Ginsenosides are Dependent on the Glycosidase Activities of the A/J Mouse Intestinal Microbiome Defined by Pyrosequencing.
  Niu T, Smith DL, Yang Z, Gao S, Yin T, Jiang ZH, You M, Gibbs RA, Petrosino JF, Hu M.Pharm Res. 2012 Dec 20. [Epub ahead of print]
• 3. Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study.
  Choi YD, Park CW, Jang J, Kim SH, Jeon HY, Kim WG, Lee SJ, Chung WS.Int J Impot Res. 2012 Dec 20. doi: 10.1038/ijir.2012.45. [Epub ahead of print]
• 4. Ginseng Berry Extract Prevents Atherogenesis via Anti-Inflammatory Action by Upregulating Phase II Gene Expression.
  Kim CK, Cho DH, Lee KS, Lee DK, Park CW, Kim WG, Lee SJ, Ha KS, Goo Taeg O, Kwon YG, Kim YM.Evid Based Complement Alternat Med. 2012;2012:490301. doi: 10.1155/2012/490301. Epub 2012 Nov 25.
• 5. Cerebroprotective effects of Red ginseng extract pretreatment against ischemia-induced oxidative stress and apoptosis.
  Cheon SY, Cho KJ, Lee JE, Kim HW, Lee SK, Kim HJ, Kim GW.Int J Neurosci. 2012 Dec 17. [Epub ahead of print]
• 6. Research and development of the effective components of panaxdiol saponin as new chinese patent medicine for treating hemocytopenia.
  Gao RL, Chong BH.Chin J Integr Med. 2012 Dec;18(12):897-902. doi: 10.1007/s11655-012-1292-4. Epub 2012 Dec 13.
• 7. Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats.
  Han SY, Li HX, Ma X, Zhang K, Ma ZZ, Tu PF.J Ethnopharmacol. 2012 Dec 10. doi:pii: S0378-8741(12)00813-6.  10.1016/j.jep.2012.11.036. [Epub ahead of print]
• 8. [Comparison on appearance and non-ginsenoside composition in Panax ginseng and its products processed from different producing areas in northeast China].
  Wu X, Ye Z, Guo Q, Lu Z.Zhongguo Zhong Yao Za Zhi. 2012 Aug;37(16):2383-7. Chinese.
• 9. Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high fat diet-induced obese C57BL/6J mice.
  Park D, Lee H, Yoon M.Food Chem Toxicol. 2012 Dec 8. doi:pii: S0278-6915(12)00859-9.  10.1016/j.fct.2012.11.052. [Epub ahead of print]
• 10. Do energy drinks contain active components other than caffeine?
  McLellan TM, Lieberman HR.Nutr Rev. 2012 Dec;70(12):730-44. doi: 10.1111/j.1753-4887.2012.00525.x. Epub 2012 Nov 9.
• 11. Cytotoxicity of herbal extracts used for treatment of prostatic disease             on head and neck carcinoma cell lines and non-malignant primary mucosal cells.
  Schmidt M, Polednik C, Roller J, Hagen R.Oncol Rep. 2013 Feb;29(2):628-36. doi: 10.3892/or.2012.2145. Epub 2012 Nov 19.
• 12. Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model.
  Cho E, Cho SH.J Ethnopharmacol. 2012 Nov 10. doi:pii: S0378-8741(12)00765-9.  10.1016/j.jep.2012.11.006. [Epub ahead of print]
• 13. Implication of the Stereoisomers of Ginsenoside Derivatives in the Antiproliferative Effect of HSC-T6 Cells.
  Yang H, Yoo G, Kim HS, Kim JY, Kim SO, Yoo YH, Sung SH.J Agric Food Chem. 2012 Nov 28;60(47):11759-64. doi: 10.1021/jf303714c. Epub 2012 Nov 19.
• 14. Red ginseng extract attenuates kainate-induced excitotoxicity by antioxidative effects.
  Han JY, Ahn SY, Oh EH, Nam SY, Hong JT, Oh KW, Lee MK.Evid Based Complement Alternat Med. 2012;2012:479016. doi: 10.1155/2012/479016. Epub 2012 Oct 23.
• 15. Neoplasm Prevention and Immuno-Enhancement Mediated by Daily Consumption of a Proprietary Extract from North American Ginseng by Elderly Mice of a Cancer-Prone Strain.
  Durairaj P, Miller SC.Phytother Res. 2012 Nov 7. doi: 10.1002/ptr.4880. [Epub ahead of print]
• 16. Increased effects of ginsenosides on the expression of cholesterol 7α-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism.
  Kawase A, Yamada A, Gamou Y, Tahara C, Takeshita F, Murata K, Matsuda H, Samukawa K, Iwaki M.J Nat Med. 2012 Oct 30. [Epub ahead of print]
• 17. Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid.
  Kim P, Park JH, Kwon KJ, Kim KC, Kim HJ, Lee JM, Kim HY, Han SH, Shin CY.Food Chem Toxicol. 2012 Oct 24;51C:288-296. doi: 10.1016/j.fct.2012.10.011. [Epub ahead of print]
• 18. Panax ginseng reduces oxidative stress and restores antioxidant capacity in aged rats.
  Ramesh T, Kim SW, Hwang SY, Sohn SH, Yoo SK, Kim SK.Nutr Res. 2012 Sep;32(9):718-26. doi: 10.1016/j.nutres.2012.08.005.
• 19. The effect of ultrasonication on the immunomodulatory activity of low-quality ginseng.
  Seo YC, Ha JH, Choi WY, Lee CG, Song CH, Lim HW, Lee HY.Biotechnol Prog. 2012 Oct 16. doi: 10.1002/btpr.1645. [Epub ahead of print]
• 20. American ginseng inhibits vascular smooth muscle cell proliferation via suppressing Jak/Stat pathway.
  Wu Q, Wang W, Li S, Nagarkatti P, Nagarkatti M, Windust A, Wang XL, Tang D, Cui T.J Ethnopharmacol. 2012 Dec 18;144(3):782-5. doi: 10.1016/j.jep.2012.09.046. Epub 2012 Oct 4.