Standard Herbal Extract

Gymnema Extract Safety Tips

Handling of Gymnema Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Advantage of Guarana (Paullinia cupana Mart.) Supplementation on Cadmium-induced Damages in Testis of Adult Wistar Rats.
  Leite RP, Predes FS, Monteiro JC, Freitas KM, Wada RS, Dolder H.Toxicol Pathol. 2013;41(1):73-9. doi: 10.1177/0192623312447541. Epub 2012 Jun 1.
• 2. Paullinia cupana Mart. var. Sorbilis protects human dopaminergic neuroblastoma SH-SY5Y cell line against rotenone-induced cytotoxicity.
  de Oliveira DM, Barreto G, Galeano P, Romero JI, Holubiec MI, Badorrey MS, Capani F, Alvarez LD.Hum Exp Toxicol. 2011 Sep;30(9):1382-91. doi: 10.1177/0960327110389837. Epub 2010 Nov 16.
• 3. Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test.
  Roncon CM, Biesdorf de Almeida C, Klein T, de Mello JC, Audi EA.Planta Med. 2011 Feb;77(3):236-41. doi: 10.1055/s-0030-1250315. Epub 2010 Sep 15.
• 4. Acute and subchronic toxicological evaluation of the semipurified extract of seeds of guaraná (Paullinia cupana) in rodents.
  Antonelli-Ushirobira TM, Kaneshima EN, Gabriel M, Audi EA, Marques LC, Mello JC.Food Chem Toxicol. 2010 Jul;48(7):1817-20. doi: 10.1016/j.fct.2010.04.013. Epub 2010 Apr 14.
• 5. Inhibitory effects of guarana seed extract on passive cutaneous anaphylaxis and mast cell degranulation.
  Jippo T, Kobayashi Y, Sato H, Hattori A, Takeuchi H, Sugimoto K, Shigekawa M.Biosci Biotechnol Biochem. 2009 Sep;73(9):2110-2. Epub 2009 Sep 7.
• 6. Effect of lyophilized extracts from guaraná seeds [Paullinia cupana var. sorbilis (Mart.) Ducke] on behavioral profiles in rats.
  Otobone FJ, Sanches AC, Nagae R, Martins JV, Sela VR, de Mello JC, Audi EA.Phytother Res. 2007 Jun;21(6):531-5.
• 7. New-onset seizures in adults: possible association with consumption of popular energy drinks.
  Iyadurai SJ, Chung SS.Epilepsy Behav. 2007 May;10(3):504-8. Epub 2007 Mar 8.
• 8. Fluid bed drying of guarana (Paullinia cupana HBK) extract: effect of process factors on caffeine content.
  Pagliarussi RS, Bastos JK, Freitas LA.AAPS PharmSciTech. 2006 Jun 16;7(2):E54.
• 9. Acute effects of guarana (Paullinia cupana Mart.) on mouse behaviour in forced swimming and open field tests.
  Campos AR, Barros AI, Albuquerque FA, M Leal LK, Rao VS.Phytother Res. 2005 May;19(5):441-3.
• 10. Antibacterial and antioxidant activities of ethanol extract from Paullinia cupana Mart.
  Basile A, Ferrara L, Pezzo MD, Mele G, Sorbo S, Bassi P, Montesano D.J Ethnopharmacol. 2005 Oct 31;102(1):32-6.
• 11. Liquid chromatographic determination of methylxanthines and catechins in herbal preparations containing guaraná.
  Carlson M, Thompson RD.J AOAC Int. 1998 Jul-Aug;81(4):691-701.
• 12. Effect of guarana on exercise in normal and epinephrine-induced glycogenolytic mice.
  Miura T, Tatara M, Nakamura K, Suzuki I.Biol Pharm Bull. 1998 Jun;21(6):646-8.
• 13. Inhibition of lymphocyte activation by extracts and fractions of Kalanchoe, Alternanthera, Paullinia and Mikania species.
  Moraes VL, Santos LF, Castro SB, Loureiro LH, Lima OA, Souza ML, Yien LM, Rossi-Bergmann B, Costa SS.Phytomedicine. 1994 Dec;1(3):199-204. doi: 10.1016/S0944-7113(11)80065-6.
• 14. HPLC determination of caffeine and theophylline in Paullinia cupana Kunth (guarana) and Cola spp. samples.
  Belliardo F, Martelli A, Valle MG.Z Lebensm Unters Forsch. 1985 May;180(5):398-401.

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