Standard Herbal Extract

Gynostemma Extract Safety Tips

Handling of Gynostemma Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Determination of gymnemagenin in rat plasma using high-performance liquid chromatography-tandem mass spectrometry: application to pharmacokinetics after oral administration of Gymnema sylvestre extract.
  Kamble B, Gupta A, Patil D, Khatal L, Janrao S, Moothedath I, Duraiswamy B.Biomed Chromatogr. 2012 Dec 7. doi: 10.1002/bmc.2845. [Epub ahead of print]
• 2. Toxicity of saponin isolated from Gymnema sylvestre R. Br. (Asclepiadaceae) against Culex tritaeniorhynchus Giles (Diptera: Culicidae) Japanese encephalitis vector mosquito in India.
  Elumalai K, Dhanasekaran S, Krishnappa K.Rev Inst Med Trop Sao Paulo. 2012 Dec;54(6):337-44.
• 3. Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model.
  Kumar V, Bhandari U, Tripathi CD, Khanna G.Indian J Pharmacol. 2012 Sep;44(5):607-13. doi: 10.4103/0253-7613.100387.
• 4. Quantitative Estimation of Gymnemagenin in Gymnema sylvestre Extract and its Marketed Formulations using the HPLC-ESI-MS/MS Method.
  Kamble B, Gupta A, Patil D, Janrao S, Khatal L, Duraiswamy B.Phytochem Anal. 2012 Sep 17. doi: 10.1002/pca.2392. [Epub ahead of print]
• 5. Possible biochemical effects following inhibition of ethanol-induced gastric mucosa damage by Gymnema sylvestre in male Wistar albino rats.
  Al-Rejaie SS, Abuohashish HM, Ahmed MM, Aleisa AM, Alkhamees O.Pharm Biol. 2012 Dec;50(12):1542-50. doi: 10.3109/13880209.2012.694894. Epub 2012 Sep 15.
• 6. A Novel Extract of Gymnema sylvestre Improves Glucose Tolerance In Vivo and Stimulates Insulin Secretion and Synthesis In Vitro.
  Al-Romaiyan A, King AJ, Persaud SJ, Jones PM.Phytother Res. 2012 Aug 21. doi: 10.1002/ptr.4815. [Epub ahead of print]
• 7. Investigation of intracellular signalling cascades mediating stimulatory effect of a Gymnema sylvestre extract on insulin secretion from isolated mouse and human islets of Langerhans.
  Al-Romaiyan A, Liu B, Docherty R, Huang GC, Amiel S, Persaud SJ, Jones PM.Diabetes Obes Metab. 2012 Jul 6;9999(9999). doi: 10.1111/j.1463-1326.2012.01660.x. [Epub ahead of print]
• 8. The saponin-rich fraction of a Gymnema sylvestre R. Br. aqueous leaf extract reduces cafeteria and high-fat diet-induced obesity.
  Reddy RM, Latha PB, Vijaya T, Rao DS.Z Naturforsch C. 2012 Jan-Feb;67(1-2):39-46.
• 9. Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats.
  Kang MH, Lee MS, Choi MK, Min KS, Shibamoto T.J Agric Food Chem. 2012 Mar 14;60(10):2517-24. doi: 10.1021/jf205086b. Epub 2012 Mar 6.
• 10. Antidiabetic activity of alcoholic stem extract of Gymnema montanum in streptozotocin-induced diabetic rats.
  Ramkumar KM, Vanitha P, Uma C, Suganya N, Bhakkiyalakshmi E, Sujatha J.Food Chem Toxicol. 2011 Dec;49(12):3390-4. doi: 10.1016/j.fct.2011.09.027. Epub 2011 Sep 29.
• 11. Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India.
  Kamaraj C, Kaushik NK, Mohanakrishnan D, Elango G, Bagavan A, Zahir AA, Rahuman AA, Sahal D.Parasitol Res. 2012 Aug;111(2):703-15. doi: 10.1007/s00436-011-2457-6. Epub 2011 Jun 4.
• 12. Biolarvicidal compound gymnemagenol isolated from leaf extract of miracle fruit plant, Gymnema sylvestre (Retz) Schult against malaria and filariasis vectors.
  Khanna VG, Kannabiran K, Rajakumar G, Rahuman AA, Santhoshkumar T.Parasitol Res. 2011 Nov;109(5):1373-86. doi: 10.1007/s00436-011-2384-6. Epub 2011 May 3.
• 13. A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro.
  Al-Romaiyan A, Liu B, Asare-Anane H, Maity CR, Chatterjee SK, Koley N, Biswas T, Chatterji AK, Huang GC, Amiel SA, Persaud SJ, Jones PM.Phytother Res. 2010 Sep;24(9):1370-6. doi: 10.1002/ptr.3125.
• 14. Insecticidal and larvicidal activities of medicinal plant extracts against mosquitoes.
  Kamaraj C, Rahuman AA, Mahapatra A, Bagavan A, Elango G.Parasitol Res. 2010 Nov;107(6):1337-49. doi: 10.1007/s00436-010-2006-8. Epub 2010 Aug 6.
• 15. In vitro callus and in vivo leaf extract of Gymnema sylvestre stimulate β-cells regeneration and anti-diabetic activity in Wistar rats.
  Ahmed AB, Rao AS, Rao MV.Phytomedicine. 2010 Nov;17(13):1033-9. doi: 10.1016/j.phymed.2010.03.019. Epub 2010 Jul 27.
• 16. Evaluation of evidenced-based radioprotective efficacy of Gymnema sylvestre leaves in mice brain.
  Sharma K, Singh U, Vats S, Priyadarsini K, Bhatia A, Kamal R.J Environ Pathol Toxicol Oncol. 2009;28(4):311-23.
• 17. Antigenotoxic potential of Gymnema montanum leaves on DNA damage in human peripheral blood lymphocytes and HL-60 cell line.
  Ramkumar KM, Sankar L, Manjula C, Krishnamurthi K, Devi SS, Chakrabarti T, Kalaiselvi K, Palanivel M, Rajaguru P.Environ Mol Mutagen. 2010 May;51(4):285-93. doi: 10.1002/em.20543.
• 18. Gymnema montanum H. protects against alloxan-induced oxidative stress and apoptosis in pancreatic beta-cells.
  Ramkumar KM, Lee AS, Krishnamurthi K, Devi SS, Chakrabarti T, Kang KP, Lee S, Kim W, Park SK, Lee NH, Rajaguru P.Cell Physiol Biochem. 2009;24(5-6):429-40. doi: 10.1159/000257480. Epub 2009 Nov 4.
• 19. Complementary and comparative study on hypoglycemic and antihyperglycemic activity of various extracts of Eugenia jambolana seed, Momordica charantia fruits, Gymnema sylvestre, and Trigonella foenum graecum seeds in rats.
  Yadav M, Lavania A, Tomar R, Prasad GB, Jain S, Yadav H.Appl Biochem Biotechnol. 2010 Apr;160(8):2388-400. doi: 10.1007/s12010-009-8799-1. Epub 2009 Nov 11.
• 20. A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats.
  Daisy P, Eliza J, Mohamed Farook KA.J Ethnopharmacol. 2009 Nov 12;126(2):339-44. doi: 10.1016/j.jep.2009.08.018. Epub 2009 Aug 22.

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