Standard Herbal Extract

Hawthorn Berry Extract Safety Tips

Handling of Hawthorn Berry Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients.
  Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG.Evid Based Complement Alternat Med. 2012;2012:452313. doi: 10.1155/2012/452313. Epub 2012 Oct 17.
• 2. Dammarane glycosides from the root of Machilus yaoshansis.
  Gan M, Liu M, Gan L, Lin S, Liu B, Zhang Y, Zi J, Song W, Shi J.J Nat Prod. 2012 Jul 27;75(7):1373-82. doi: 10.1021/np300310a. Epub 2012 Jul 10.
• 3. Restoration of electric footshock-induced immunosuppression in mice by Gynostemma pentaphyllum components.
  Im SA, Choi HS, Choi SO, Kim KH, Lee S, Hwang BY, Lee MK, Lee CK.Molecules. 2012 Jun 25;17(7):7695-708. doi: 10.3390/molecules17077695.
• 4. Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase.
  Gauhar R, Hwang SL, Jeong SS, Kim JE, Song H, Park DC, Song KS, Kim TY, Oh WK, Huh TL.Biotechnol Lett. 2012 Sep;34(9):1607-16. doi: 10.1007/s10529-012-0944-1. Epub 2012 May 11.
• 5. Preconditioning of brain slices against hypoxia induced injury by a Gynostemma pentaphyllum extract–stimulation of anti-oxidative enzyme expression.
  Schild L, Cotte T, Keilhoff G, Brödemann R.Phytomedicine. 2012 Jun 15;19(8-9):812-8. doi: 10.1016/j.phymed.2012.03.012. Epub 2012 Apr 17.
• 6. Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract.
  Müller C, Gardemann A, Keilhoff G, Peter D, Wiswedel I, Schild L.Phytomedicine. 2012 Mar 15;19(5):395-401. doi: 10.1016/j.phymed.2011.12.002. Epub 2012 Feb 29.
• 7. New dammarane-type glycosides from the roots of Gynostemma pentaphyllum.
  Ma L, Xiang WJ, Khang PV, Liang Y, Xiao Y, Hu LH.Planta Med. 2012 Apr;78(6):597-605. doi: 10.1055/s-0031-1298256. Epub 2012 Feb 14.
• 8. Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation.
  Zhang GL, Deng JP, Wang BH, Zhao ZW, Li J, Gao L, Liu BL, Xong JR, Guo XD, Yan ZQ, Gao GD.Behav Pharmacol. 2011 Oct;22(7):633-44. doi: 10.1097/FBP.0b013e32834afef9.
• 9. Antimicrobial activity of Gynostemma pentaphyllum extracts against fungi producing aflatoxin and fumonisin and bacteria causing diarrheal disease.
  Srichana D, Taengtip R, Kondo S.Southeast Asian J Trop Med Public Health. 2011 May;42(3):704-10.
• 10. Dammarane-type saponins from Gynostemma pentaphyllum.
  Kim JH, Han YN.Phytochemistry. 2011 Aug;72(11-12):1453-9. doi: 10.1016/j.phytochem.2011.04.003. Epub 2011 May 10.
• 11. Gypenosides protects dopaminergic neurons in primary culture against MPP(+)-induced oxidative injury.
  Wang P, Niu L, Guo XD, Gao L, Li WX, Jia D, Wang XL, Ma LT, Gao GD.Brain Res Bull. 2010 Oct 30;83(5):266-71. doi: 10.1016/j.brainresbull.2010.06.014. Epub 2010 Jul 6.
• 12. Long-term oral administration of Gynostemma pentaphyllum extract attenuates airway inflammation and Th2 cell activities in ovalbumin-sensitized mice.
  Liou CJ, Huang WC, Kuo ML, Yang RC, Shen JJ.Food Chem Toxicol. 2010 Oct;48(10):2592-8. doi: 10.1016/j.fct.2010.06.020. Epub 2010 Jun 15.
• 13. Dammarane-type saponins from Gynostemma pentaphyllum.
  Ky PT, Huong PT, My TK, Anh PT, Kiem PV, Minh CV, Cuong NX, Thao NP, Nhiem NX, Hyun JH, Kang HK, Kim YH.Phytochemistry. 2010 Jun;71(8-9):994-1001. doi: 10.1016/j.phytochem.2010.03.009. Epub 2010 Apr 9.
• 14. Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extract.
  Schild L, Chen BH, Makarov P, Kattengell K, Heinitz K, Keilhoff G.Phytomedicine. 2010 Jul;17(8-9):589-97. doi: 10.1016/j.phymed.2009.12.002. Epub 2010 Jan 27.
• 15. Dammarane-type glycosides from Gynostemma pentaphyllum and their effects on IL-4-induced eotaxin expression in human bronchial epithelial cells.
  Hung TM, Thu CV, Cuong TD, Hung NP, Kwack SJ, Huh JI, Min BS, Choi JS, Lee HK, Bae K.J Nat Prod. 2010 Feb 26;73(2):192-6. doi: 10.1021/np9006712.
• 16. The inhibitory effect of Gynostemma pentaphyllum on MCP-1 and type I procollagen expression in rat hepatic stellate cells.
  Chen MH, Wang QF, Chen LG, Shee JJ, Chen JC, Chen KY, Chen SH, Su JG, Liu YW.J Ethnopharmacol. 2009 Oct 29;126(1):42-9. doi: 10.1016/j.jep.2009.08.012. Epub 2009 Aug 21.
• 17. Antioxidant activity of Tartary buckwheat bran extract and its effect on the lipid profile of hyperlipidemic rats.
  Wang M, Liu JR, Gao JM, Parry JW, Wei YM.J Agric Food Chem. 2009 Jun 10;57(11):5106-12. doi: 10.1021/jf900194s.
• 18. Protection of hippocampal slices against hypoxia/hypoglycemia injury by a Gynostemma pentaphyllum extract.
  Schild L, Roth A, Keilhoff G, Gardemann A, Brödemann R.Phytomedicine. 2009 Aug;16(8):734-43. doi: 10.1016/j.phymed.2009.03.006. Epub 2009 Apr 29.
• 19. Protein tyrosine phosphatase 1B inhibitory by dammaranes from Vietnamese Giao-Co-Lam tea.
  Hung TM, Hoang DM, Kim JC, Jang HS, Ahn JS, Min BS.J Ethnopharmacol. 2009 Jul 15;124(2):240-5. doi: 10.1016/j.jep.2009.04.027. Epub 2009 May 3.
• 20. A combination of grape seed-derived procyanidins and gypenosides alleviates insulin resistance in mice and HepG2 cells.
  Zhang HJ, Ji BP, Chen G, Zhou F, Luo YC, Yu HQ, Gao FY, Zhang ZP, Li HY.J Food Sci. 2009 Jan-Feb;74(1):H1-7. doi: 10.1111/j.1750-3841.2008.00976.x.

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