Standard Herbal Extract

Pine Bark Extract Safety Tips

Handling of Pine Bark Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Chemopreventive efficacy of Phyllanthus emblica L. (amla) fruit extract on 7,12-dimethylbenz(a)anthracene induced oral carcinogenesis – A dose-response study.
  Krishnaveni M, Mirunalini S.Environ Toxicol Pharmacol. 2012 Nov;34(3):801-10. doi: 10.1016/j.etap.2012.09.006. Epub 2012 Sep 24.
• 2. Studies on effects of Emblica officinalis (Amla) on oxidative stress and cholinergic function in scopolamine induced amnesia in mice.
  Golechha M, Bhatia J, Arya DS.J Environ Biol. 2012 Jan;33(1):95-100.
• 3. Studies on Prokinetic, Laxative, and Spasmodic Activities of Phyllanthus emblica in Experimental Animals.
  Mehmood MH, Rehman A, Najeeb-Ur-Rehman, Gilani AH.Phytother Res. 2012 Sep 12. doi: 10.1002/ptr.4821. [Epub ahead of print]
• 4. Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway.
  Chatterjee A, Chatterjee S, Biswas A, Bhattacharya S, Chattopadhyay S, Bandyopadhyay SK.Evid Based Complement Alternat Med. 2012;2012:487380. doi: 10.1155/2012/487380. Epub 2012 Aug 26.
• 5. Antidiabetic and antioxidant potential of Emblica officinalis Gaertn. leaves extract in streptozotocin-induced type-2 diabetes mellitus (T2DM) rats.
  Nain P, Saini V, Sharma S, Nain J.J Ethnopharmacol. 2012 Jun 26;142(1):65-71.
• 6. Evaluation of 15 Local Plant Species as Larvicidal Agents Against an Indian Strain of Dengue Fever Mosquito, Aedes aegypti L. (Diptera: Culicidae).
  Kumar S, Wahab N, Mishra M, Warikoo R.Front Physiol. 2012;3:104. doi: 10.3389/fphys.2012.00104. Epub 2012 Apr 23.
• 7. Mitigation of DMBA-induced mammary carcinoma in experimental rats by antiangiogenic property of Kalpaamruthaa.
  Sathish S, Shanthi P, Sachdanandam P.J Diet Suppl. 2011 Jun;8(2):144-57. doi: 10.3109/19390211.2011.561824. Epub 2011 Apr 13.
• 8. 5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment.
  Kumar N, Rungseevijitprapa W, Narkkhong NA, Suttajit M, Chaiyasut C.J Ethnopharmacol. 2012 Feb 15;139(3):765-71. doi: 10.1016/j.jep.2011.12.010. Epub 2011 Dec 13.
• 9. Influence of Emblica officinalis aqueous extract on growth and antioxidant defense system of human hepatoma cell line (HepG2).
  Shivananjappa MM, Joshi MK.Pharm Biol. 2012 Apr;50(4):497-505. doi: 10.3109/13880209.2011.618501. Epub 2011 Dec 1.
• 10. Possible involvement of monoaminergic neurotransmission in antidepressant-like activity of Emblica officinalis fruits in mice.
  Dhingra D, Joshi P, Gupta A, Chhillar R.CNS Neurosci Ther. 2012 May;18(5):419-25. doi: 10.1111/j.1755-5949.2011.00256.x. Epub 2011 Jun 7.
• 11. Comparative study of antimicrobial activity and phytochemical analysis of methanolic and aqueous extracts of the fruit of Emblica officinalis against pathogenic bacteria.
  Kumar A, Tantry BA, Rahiman S, Gupta U.J Tradit Chin Med. 2011 Sep;31(3):246-50.
• 12. Effect of Phyllanthus emblica Linn. on candida adhesion to oral epithelium and denture acrylic.
  Thaweboon B, Thaweboon S.Asian Pac J Trop Med. 2011 Jan;4(1):41-5. doi: 10.1016/S1995-7645(11)60029-1. Epub 2011 Jan 15.
• 13. Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory, and neuroprotective intervention.
  Golechha M, Bhatia J, Ojha S, Arya DS.Pharm Biol. 2011 Nov;49(11):1128-36. doi: 10.3109/13880209.2011.571264. Epub 2011 Jul 12.
• 14. Emblica officinalis exerts antihypertensive effect in a rat model of DOCA-salt-induced hypertension: role of (p) eNOS, NO and oxidative stress.
  Bhatia J, Tabassum F, Sharma AK, Bharti S, Golechha M, Joshi S, Sayeed Akhatar M, Srivastava AK, Arya DS.Cardiovasc Toxicol. 2011 Sep;11(3):272-9. doi: 10.1007/s12012-011-9122-2.
• 15. Efficacy of epigallocatechin-3-gallate and Amla (Emblica officinalis) extract for the treatment of diabetic-uremic patients.
  Chen TS, Liou SY, Wu HC, Tsai FJ, Tsai CH, Huang CY, Chang YL.J Med Food. 2011 Jul-Aug;14(7-8):718-23. doi: 10.1089/jmf.2010.1195. Epub 2011 Jun 1.
• 16. Inhibition of UV-induced ROS and collagen damage by Phyllanthus emblica extract in normal human dermal fibroblasts.
  Majeed M, Bhat B, Anand S, Sivakumar A, Paliwal P, Geetha KG.J Cosmet Sci. 2011 Jan-Feb;62(1):49-56.
• 17. Emblica officinalis corrects functional, biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido-nitrosative stress mediated inflammatory cascade.
  Tiwari V, Kuhad A, Chopra K.Phytother Res. 2011 Oct;25(10):1527-36. doi: 10.1002/ptr.3440. Epub 2011 Mar 11.
• 18. In vitro and in vivo antiplasmodial activity and cytotoxicity of water extracts of Phyllanthus emblica, Terminalia chebula, and Terminalia bellerica.
  Pinmai K, Hiriote W, Soonthornchareonnon N, Jongsakul K, Sireeratawong S, Tor-Udom S.J Med Assoc Thai. 2010 Dec;93 Suppl 7:S120-6.
• 19. Emblica officinalis ameliorates alcohol-induced brain mitochondrial dysfunction in rats.
  Reddy VD, Padmavathi P, Kavitha G, Gopi S, Varadacharyulu N.J Med Food. 2011 Jan-Feb;14(1-2):62-8. doi: 10.1089/jmf.2010.1122. Epub 2010 Dec 7.
• 20. The antidiarrheal and spasmolytic activities of Phyllanthus emblica are mediated through dual blockade of muscarinic receptors and Ca2+ channels.
  Mehmood MH, Siddiqi HS, Gilani AH.J Ethnopharmacol. 2011 Jan 27;133(2):856-65. doi: 10.1016/j.jep.2010.11.023. Epub 2010 Nov 17.

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