Hederagenin (CAS: 465-99-6)
Hederagenin (CAS: 465-99-6) is the aglycone part of numerous saponins found in Hedera helix (common ivy), the most prevalent of these being hederacoside C and alpha-hederin.
| CAS Number | 465-99-6 |
| Appearance | White crystalline powder |
| Type | Triterpenoid |
| Source | Natural Ivy Leaf |
| Keywords | Hederagenin |
| Synonyms | HG |
Hederagenin (CAS: 465-99-6) Description
Hederagenin (CAS: 465-99-6) is a sapogenin found in Hedera helix (common ivy), particularly in saponins like hederacoside C and alpha-hederin. It’s also a key triterpenoid in Chenopodium quinoa, recognized by the EPA as a biopesticide component. Demonstrating antidepressant-like effects in rodent studies, Hederagenin is a plant-derived pentacyclic triterpenoid, akin to oleanolic acid, with roles as a plant metabolite and dihydroxy monocarboxylic acid.
Hederagenin (CAS: 465-99-6) Specifications
| Product Name | Hederagenin |
| CAS Registry Number | 465-99-6 |
| Molecular Formula | C30H48O4 |
| Molecular Weight | 472.710 g/mol |
| Assay | ≥97% |
| Solubility | Methanol: 1 mg/mL |
Hederagenin (CAS: 465-99-6) Applications
- Anti-tumor Activity: Hederagenin demonstrates broad anti-tumor effects against various cancers including lung, colon, stomach, liver, ovarian, prostate, breast, and endometrial. It operates by modifying gene/protein expression, reducing tumor weight and altering the expression of several key genes and proteins related to cancer progression.
- Anti-inflammatory Activity: Since the 1970s, Hederagenin has shown anti-inflammatory and anti-arthritic effects. In mouse models, it significantly reduced edema, showcasing its potential as an anti-inflammatory agent.
- Anti-depressant Activity: Hederagenin enhances central monoamine signaling by inhibiting the reuptake of serotonin, norepinephrine, and dopamine, acting as a triple inhibitor of monoamine transporters. This contributes to its antidepressant effects.
- Anti-neurodegenerative Activity: It activates autophagy, promoting the clearance of proteins associated with neurodegenerative diseases like Parkinson’s and Huntington’s, and has shown potential in improving motor deficits and cognitive functions in animal models.
- Anti-hyperlipidemia Activity: In a rat model, Hederagenin reduced cholesterol, triglycerides, and improved liver function and blood viscosity, indicating its potential in treating hyperlipidemia.
- Anti-leishmanial Activity: As a biopesticide, Hederagenin sodium salt has shown effectiveness against Leishmania strains in vitro, comparable to reference compounds, highlighting its potential as a leishmanicidal agent.
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