Botanical Ingredient

Allicin Safety Tips

Handling of Allicin should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Effect of allicin on promastigotes and intracellular amastigotes of Leishmania donovani and L. infantum.
  Jesús Corral-Caridad M, Moreno I, Toraño A, Domínguez M, Alunda JM.Exp Parasitol. 2012 Dec;132(4):475-82. doi: 10.1016/j.exppara.2012.08.016. Epub 2012 Sep 17.
• 2. Allicin Ameliorates Cardiac Hypertrophy and Fibrosis through Enhancing of Nrf2 Antioxidant Signaling Pathways.
  Li XH, Li CY, Xiang ZG, Hu JJ, Lu JM, Tian RB, Jia W.Cardiovasc Drugs Ther. 2012 Dec;26(6):457-65. doi: 10.1007/s10557-012-6415-z.
• 3. S-allyl derivatives of 6-mercaptopurine are highly potent drugs against human B-CLL through synergism between 6-mercaptopurine and allicin.
  Miron T, Wilchek M, Shvidel L, Berrebi A, Arditti FD.Leuk Res. 2012 Dec;36(12):1536-40. doi: 10.1016/j.leukres.2012.08.023. Epub 2012 Sep 4.
• 4. Garlic extracts prevent oxidative stress, hypertrophy and apoptosis in cardiomyocytes: a role for nitric oxide and hydrogen sulfide.
  Louis XL, Murphy R, Thandapilly SJ, Yu L, Netticadan T.BMC Complement Altern Med. 2012 Aug 29;12:140. doi: 10.1186/1472-6882-12-140.
• 5. Cholesterol-lowering effect of allicin on hypercholesterolemic ICR mice.
  Lu Y, He Z, Shen X, Xu X, Fan J, Wu S, Zhang D.Oxid Med Cell Longev. 2012;2012:489690. doi: 10.1155/2012/489690. Epub 2012 Aug 9.
• 6. A Review of the Cardiovascular Benefits and Antioxidant Properties of Allicin.
  Chan JY, Yuen AC, Chan RY, Chan SW.Phytother Res. 2012 Aug 8. doi: 10.1002/ptr.4796. [Epub ahead of print]
• 7. Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells.
  Hu Y, Chen L, Yi C, Yang F, Chen J.J Huazhong Univ Sci Technolog Med Sci. 2012 Aug;32(4):581-5. doi: 10.1007/s11596-012-1000-z. Epub 2012 Aug 11.
• 8. Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection.
  Feng Y, Zhu X, Wang Q, Jiang Y, Shang H, Cui L, Cao Y.Malar J. 2012 Aug 8;11:268. doi: 10.1186/1475-2875-11-268.
• 9. Use of complementary medicine amongst patients on antiretroviral drugs in an HIV treatment centre in Lagos, Nigeria.
  Awodele O, Olayemi SO, Adeyemo TA, Sanya TA, Dolapo DC.Curr Drug Saf. 2012 Apr;7(2):120-5.
• 10. Traceability of Italian garlic (Allium sativum L.) by means of HRMAS-NMR spectroscopy and multivariate data analysis.
  Ritota M, Casciani L, Han BZ, Cozzolino S, Leita L, Sequi P, Valentini M.Food Chem. 2012 Nov 15;135(2):684-93. doi: 10.1016/j.foodchem.2012.05.032. Epub 2012 May 11.
• 11. Allicin Induces p53-Mediated Autophagy in Hep G2 Human Liver Cancer Cells.
  Chu YL, Ho CT, Chung JG, Rajasekaran R, Sheen LY.J Agric Food Chem. 2012 Aug 15. [Epub ahead of print]
• 12. Neuroprotective effects of allicin on spinal cord ischemia-reperfusion injury via improvement of mitochondrial function in rabbits.
  Zhu JW, Chen T, Guan J, Liu WB, Liu J.Neurochem Int. 2012 Oct;61(5):640-8. doi: 10.1016/j.neuint.2012.06.021. Epub 2012 Jun 29.
• 13. Protective effect of allicin against acrylamide-induced hepatocyte damage in vitro and in vivo.
  Zhang L, Zhang H, Miao Y, Wu S, Ye H, Yuan Y.Food Chem Toxicol. 2012 Sep;50(9):3306-12. doi: 10.1016/j.fct.2012.05.060. Epub 2012 Jun 13.
• 14. Garlicnins B(1), C(1), and D, from the fraction regulating macrophage activation of Allium sativum.
  Nohara T, Kiyota Y, Sakamoto T, Manabe H, Ono M, Ikeda T, Fujiwara Y, Nakano D, Kinjo J.Chem Pharm Bull (Tokyo). 2012;60(6):747-51.
• 15. Quantitative and qualitative analysis of the antifungal activity of allicin alone and in combination with antifungal drugs.
  Kim YS, Kim KS, Han I, Kim MH, Jung MH, Park HK.PLoS One. 2012;7(6):e38242. doi: 10.1371/journal.pone.0038242. Epub 2012 Jun 5.
• 16. Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC).
  Krumm P, Giraldez T, Alvarez de la Rosa D, Clauss WG, Fronius M, Althaus M.Bioorg Med Chem. 2012 Jul 1;20(13):3979-84. doi: 10.1016/j.bmc.2012.05.021. Epub 2012 May 17.
• 17. Clinical evaluation of allicin oral adhesive tablets in the treatment of recurrent aphthous ulceration.
  Jiang XW, Zhang Y, Song GD, Li FF, Peng HY, Yang SK, Sun GL.Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Apr;113(4):500-4. doi: 10.1016/j.oooo.2011.09.007.
• 18. Allicin protects against myocardial apoptosis and fibrosis in streptozotocin-induced diabetic rats.
  Liu Y, Qi H, Wang Y, Wu M, Cao Y, Huang W, Li L, Ji Z, Sun H.Phytomedicine. 2012 Jun 15;19(8-9):693-8. doi: 10.1016/j.phymed.2012.04.007. Epub 2012 May 24.
• 19. Transformation of synthetic allicin: the influence of ultrasound, microwaves, different solvents and temperatures, and the products isolation.
  Ili? D, Nikoli? V, Stankovi? M, Nikoli? L, Stanojevi? L, Mladenovi?-Ranisavljevi? I, Smelcerovi? A.ScientificWorldJournal. 2012;2012:561823. doi: 10.1100/2012/561823. Epub 2012 May 2.
• 20. Lead compound design for TPR/COX dual inhibition.
  Krishna A, Yadav A.J Mol Model. 2012 Sep;18(9):4397-408. doi: 10.1007/s00894-012-1435-y. Epub 2012 May 16.

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