(+)-Bicuculline
– Chemical Name: (+)-Bicuculline
– Molecular Formula: C_20H_17NO_6
– Molecular Weight: 367.35 g/mol
– Purity: ≥98%
– Appearance: White to off-white crystalline powder
– Solubility: Soluble in DMSO, methanol; slightly soluble in water
– Storage: Store at -20°C, in a sealed container, protected from light
Description
(+)-Bicuculline is a renowned compound in the field of neuroscience and pharmacology, known for its role as a potent GABA antagonist. This alkaloid, extracted from Dicentra cucullaria and other plant sources, is pivotal in neurophysiological research, particularly for its ability to block GABA_A receptors. Its structure and function have been a subject of interest for researchers studying synaptic transmission, neuronal excitability, and the mechanisms underlying various neurological conditions.
Specifications
– Chemical Name: (+)-Bicuculline
– Molecular Formula: C_20H_17NO_6
– Molecular Weight: 367.35 g/mol
– Purity: ≥98%
– Appearance: White to off-white crystalline powder
– Solubility: Soluble in DMSO, methanol; slightly soluble in water
– Storage: Store at -20°C, in a sealed container, protected from light
Applications
(+)-Bicuculline is primarily used in:
– Neuroscientific Research: To study GABAergic transmission and its effects on neuronal circuits.
– Pharmacological Studies: As a tool to understand the role of GABA_A receptors in various neurological disorders like epilepsy, anxiety, and sleep disorders.
– Neurotoxicology: Investigating the protective and toxic effects of GABAergic modulation.
Safety and Handling
– Handle with care in a well-ventilated area and with appropriate protective equipment.
– Avoid inhalation, contact with skin or eyes, and ingestion.
– In case of contact, wash thoroughly with water and seek medical advice.
Details
| Purity | ≥98% |
|---|---|
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
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