Demethoxyyangonin
Demethoxyyangonin, a major kavalactone from Piper methysticum (kava), is noted for its sedative, anxiolytic, and mood-enhancing effects, with potential neuroprotective and metabolic regulatory activities, studied for applications in mental health support, neuroprotection, and metabolic health.
Demethoxyyangonin Overview
Research on demethoxyyangonin has highlighted its potential beyond the traditional uses of kava, indicating possible applications in promoting mental health, protecting against neurodegenerative diseases, and even modulating metabolic processes. Its mechanism of action includes inhibiting monoamine oxidase B (MAO-B) and modulating the endocannabinoid system, which may underlie its effects on mood and cognition.
Demethoxyyangonin Key Features
– Natural Source: Extracted from the kava plant, Piper methysticum.
– Bioactivities: Exhibits sedative, anxiolytic, and mood-enhancing effects; also has potential neuroprotective and metabolic regulatory activities.
– Mechanism of Action: Modulates neurotransmitter systems, including GABAergic, dopaminergic, and serotonergic pathways; inhibits MAO-B; may affect the endocannabinoid system.
Demethoxyyangonin Applications
– Mental Health Support: Used in supplements aimed at reducing anxiety, promoting relaxation, and enhancing mood.
– Neuroprotection: Investigated for its potential to protect against neurodegenerative diseases through its antioxidant and neurotransmitter modulating effects.
– Metabolic Health: Early research suggests it may influence metabolic processes, offering potential benefits in metabolic syndrome and related conditions.
Demethoxyyangonin Functions
– Modulation of Neurotransmitter Activity: Influences various neurotransmitter systems to produce sedative and anxiolytic effects.
– Neuroprotection: May protect neural cells from oxidative stress and inflammation, supporting brain health.
– Metabolic Regulation: Preliminary studies indicate an impact on metabolism, possibly affecting energy balance and weight management.
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