Botanical Ingredient

Tangeretin Safety Tips

Handling of Tangeretin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Citrus flavonoids and lipid metabolism.
  Assini JM, Mulvihill EE, Huff MW.Curr Opin Lipidol. 2012 Dec 18. [Epub ahead of print]
• 2. Antioxidant activity and effective compounds of immature calamondin peel.
  Yu MW, Lou SN, Chiu EM, Ho CT.Food Chem. 2013 Feb 15;136(3-4):1130-5. doi: 10.1016/j.foodchem.2012.09.088. Epub 2012 Oct 2.
• 3. Multidrug Resistance Reversal and Apoptosis Induction in Human Colon Cancer Cells by Some Flavonoids Present in Citrus Plants.
  Weso?owska O, Wi?niewski J, Sroda-Pomianek K, Bielawska-Pohl A, Paprocka M, Du? D, Duarte N, Ferreira MJ, Michalak K.J Nat Prod. 2012 Nov 8. [Epub ahead of print]
• 4. ATF6alpha Promotes Astroglial Activation and Neuronal Survival in a Chronic Mouse Model of Parkinson’s Disease.
  Hashida K, Kitao Y, Sudo H, Awa Y, Maeda S, Mori K, Takahashi R, Iinuma M, Hori O.PLoS One. 2012;7(10):e47950. doi: 10.1371/journal.pone.0047950. Epub 2012 Oct 24.
• 5. Chemical markers of shiikuwasha juice adulterated with calamondin juice.
  Yamamoto K, Yahada A, Sasaki K, Ogawa K, Koga N, Ohta H.J Agric Food Chem. 2012 Nov 7;60(44):11182-7. doi: 10.1021/jf303374g. Epub 2012 Oct 26.
• 6. Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress.
  Chen ZT, Chu HL, Chyau CC, Chu CC, Duh PD.Food Chem. 2012 Dec 15;135(4):2119-27. doi: 10.1016/j.foodchem.2012.07.041. Epub 2012 Jul 15.
• 7. HPLC-PDA-MS and NMR Characterization of a Hydroalcoholic Extract of  Citrus aurantium  L. var. amara Peel with Antiedematogenic Activity.
  Mencherini T, Campone L, Piccinelli AL, García Mesa M, Sánchez DM, Aquino RP, Rastrelli L.J Agric Food Chem. 2012 Sep 17. [Epub ahead of print]
• 8. Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis.
  Tominari T, Hirata M, Matsumoto C, Inada M, Miyaura C.J Pharmacol Sci. 2012 Aug 18;119(4):390-4. Epub 2012 Jul 31.
• 9. The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines.
  Asikin Y, Taira I, Inafuku-Teramoto S, Sumi H, Ohta H, Takara K, Wada K.J Agric Food Chem. 2012 Aug 15;60(32):7973-80. doi: 10.1021/jf301848s. Epub 2012 Jul 31.
• 10. Mild Mitochondrial Depolarization is Involved in a Neuroprotective Mechanism of Citrus sunki Peel Extract.
  Wu JJ, Cui Y, Yang YS, Jung SC, Hyun JW, Maeng YH, Park DB, Lee SR, Kim SJ, Eun SY.Phytother Res. 2012 Jun 8. doi: 10.1002/ptr.4745. [Epub ahead of print]
• 11. Polymethoxyflavonoids Tangeretin and Nobiletin Increase Glucose Uptake in Murine Adipocytes.
  Onda K, Horike N, Suzuki TI, Hirano T.Phytother Res. 2012 May 14. doi: 10.1002/ptr.4730. [Epub ahead of print]
• 12. Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and a mouse model.
  Shih WL, Yu FL, Chang CD, Liao MH, Wu HY, Lin PY.Mol Carcinog. 2012 Apr 30. doi: 10.1002/mc.21919. [Epub ahead of print]
• 13. Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents.
  Meiyanto E, Hermawan A, Anindyajati.Asian Pac J Cancer Prev. 2012;13(2):427-36. Review.
• 14. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice.
  Kim MS, Hur HJ, Kwon DY, Hwang JT.Mol Cell Endocrinol. 2012 Jul 6;358(1):127-34. doi: 10.1016/j.mce.2012.03.013. Epub 2012 Mar 28.
• 15. Phenolic constituents from the heartwood of Artocapus altilis and their tyrosinase inhibitory activity.
  Nguyen MH, Nguyen HX, Nguyen MT, Nguyen NT.Nat Prod Commun. 2012 Feb;7(2):185-6.
• 16. Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.
  Walsky RL, Bauman JN, Bourcier K, Giddens G, Lapham K, Negahban A, Ryder TF, Obach RS, Hyland R, Goosen TC.Drug Metab Dispos. 2012 May;40(5):1051-65. doi: 10.1124/dmd.111.043117. Epub 2012 Feb 22.
• 17. Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities.
  Weng CJ, Yen GC.Cancer Metastasis Rev. 2012 Jun;31(1-2):323-51. doi: 10.1007/s10555-012-9347-y. Review.
• 18. Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS.
  Chen HF, Zhang WG, Yuan JB, Li YG, Yang SL, Yang WL.J Pharm Biomed Anal. 2012 Feb 5;59:90-5. doi: 10.1016/j.jpba.2011.10.013. Epub 2011 Oct 20.
• 19. Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation.
  Seo J, Lee HS, Ryoo S, Seo JH, Min BS, Lee JH.Eur J Pharmacol. 2011 Dec 30;673(1-3):56-64. doi: 10.1016/j.ejphar.2011.10.011. Epub 2011 Oct 21.
• 20. Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination.
  Tistaert C, Thierry L, Szandrach A, Dejaegher B, Fan G, Frédérich M, Vander Heyden Y.Anal Chim Acta. 2011 Oct 31;705(1-2):111-22. doi: 10.1016/j.aca.2011.04.024. Epub 2011 Apr 22.

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