Tetrandrine Powder
Tetrandrine (CAS: 518-34-3), a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic, and antiallergenic effects.
| CAS Number | 518-34-3 |
| Appearance | White powder |
| Type | Alkaloid |
| Source | Stephania Tetrandra Root |
| Keywords | Tetrandrine |
| Synonyms | (1)-6,6’,7,12-Tetramethoxy-2,2’-dimethylberbaman |
Tetrandrine (CAS: 518-34-3) Description
Tetrandrine (CAS: 518-34-3) is a bis-benzylisoquinoline alkaloid found in Stephania tetrandra and other Asian herbs, acting as a calcium channel blocker with anti-inflammatory, immunologic, and antiallergenic properties. It prevents mast cell degranulation and has quinidine-like effects against arrhythmias.
Notably, tetrandrine shows significant anti-tumor properties, enhancing tumor cell cytotoxicity, overcoming multidrug resistance, protecting normal tissues from radiation, and inhibiting angiogenesis. Its promising effects highlight its potential as a cancer treatment or an adjunct to conventional chemotherapy and radiotherapy.
Tetrandrine (CAS: 518-34-3) Specifications
| Product Name | Tetrandrine |
| CAS Registry Number | 518-34-3 |
| Molecular Formula | C38H42N2O6 |
| Molecular Weight | 622.75 |
| Assay | ≥90% |
| Pubchem | 73078 |
Tetrandrine (CAS: 518-34-3) Applications
– Source Plant: Stephania tetrandra from the Menispermaceae family is a major source of tetrandrine, a bisbenzylisoquinoline alkaloid.
– Traditional Use: Recognized in the Chinese Pharmacopoeia for its analgesic and diuretic properties, also used to treat hypertension, asthma, tuberculosis, dysentery, hyperglycemia, malaria, cancer, and fever.
– Calcium Channel Blocker: Acts as a calcium channel blocker with clinical trials confirming its efficacy in treating silicosis, hypertension, inflammation, and lung cancer without toxicity.
– Antimicrobial and Antiviral Activity: Proven effective against Mycobacterium tuberculosis, Candida albicans, Plasmodium falciparum, and the Ebola virus in recent studies.
– Mechanism of Action: Influences various signaling pathways including reactive oxygen species production, autophagic flux enhancement, reversal of multidrug resistance, activation of the caspase pathway, cell cycle arrest, and modification of calcium channels.
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