Standard Herbal Extract

Agaricus Blazei Murill Extract Safety Tips

Handling of Agaricus Blazei Murill Extract should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages.
  Huang TT, Ojcius DM, Young JD, Wu YH, Ko YF, Wong TY, Wu CY, Lu CC, Lai HC.PLoS One. 2012;7(7):e41383. doi: 10.1371/journal.pone.0041383. Epub 2012 Jul 23.
• 2. Prophylactic or therapeutic administration of Agaricus blazei Murill is effective in treatment of murine visceral leishmaniasis.
  Valadares DG, Duarte MC, Ramírez L, Chávez-Fumagalli MA, Martins VT, Costa LE, Lage PS, Ribeiro TG, Castilho RO, Fernandes AP, Régis WC, Soto M, Tavares CA, Coelho EA.Exp Parasitol. 2012 Oct;132(2):228-36. doi: 10.1016/j.exppara.2012.07.005. Epub 2012 Jul 20.
• 3. Therapeutic efficacy induced by the oral administration of Agaricus blazei Murill against Leishmania amazonensis.
  Valadares DG, Duarte MC, Ramírez L, Chávez-Fumagalli MA, Lage PS, Martins VT, Costa LE, Ribeiro TG, Régis WC, Soto M, Fernandes AP, Tavares CA, Coelho EA.Parasitol Res. 2012 Oct;111(4):1807-16. Epub 2012 Jul 15.
• 4. Dietary Supplementation With Agaricus Blazei Murill Extract Prevents Diet-Induced Obesity and Insulin Resistance in Rats.
  Vincent M, Philippe E, Everard A, Kassis N, Rouch C, Denom J, Takeda Y, Uchiyama S, Delzenne NM, Cani PD, Migrenne S, Magnan C.Obesity (Silver Spring). 2012 Jun 7. doi: 10.1038/oby.2012.139. [Epub ahead of print]
• 5. An extract of Agaricus blazei Murill administered orally promotes immune responses in murine leukemia BALB/c mice in vivo.
  Lin JG, Fan MJ, Tang NY, Yang JS, Hsia TC, Lin JJ, Lai KC, Wu RS, Ma CY, Wood WG, Chung JG.Integr Cancer Ther. 2012 Mar;11(1):29-36. doi: 10.1177/1534735411400314.
• 6. Effect of AndoSan™ on expression of adhesion molecules and production of reactive oxygen species in human monocytes and granulocytes in vivo.
  Johnson E, Førland DT, Hetland G, Sætre L, Olstad OK, Lyberg T.Scand J Gastroenterol. 2012 Sep;8-9(47):984-92. doi: 10.3109/00365521.2012.660544. Epub 2012 May 8.
• 7. Leishmanicidal activity of the Agaricus blazei Murill in different Leishmania species.
  Valadares DG, Duarte MC, Oliveira JS, Chávez-Fumagalli MA, Martins VT, Costa LE, Leite JP, Santoro MM, Régis WC, Tavares CA, Coelho EA.Parasitol Int. 2011 Dec;60(4):357-63. doi: 10.1016/j.parint.2011.06.001. Epub 2011 Jun 24.
• 8. Possible reduction of hepatoma formation by Smmu 7721 cells in SCID mice and metastasis formation by B16F10 melanoma cells in C57BL/6 mice by Agaricus blazei murill extract.
  Wu MF, Lu HF, Hsu YM, Tang MC, Chen HC, Lee CS, Yang YY, Yeh MY, Chung HK, Huang YP, Wu CC, Chung JG.In Vivo. 2011 May-Jun;25(3):399-404.
• 9. Agaricus blazei Murill extract abrogates CCl4-induced liver injury in rats.
  Wu MF, Hsu YM, Tang MC, Chen HC, Chung JG, Lu HF, Lin JP, Tang NY, Yeh C, Yeh MY.In Vivo. 2011 Jan-Feb;25(1):35-40.
• 10. Effect of an extract based on the medicinal mushroom Agaricus blazei Murill on expression of cytokines and calprotectin in patients with ulcerative colitis and Crohn’s disease.
  Førland DT, Johnson E, Saetre L, Lyberg T, Lygren I, Hetland G.Scand J Immunol. 2011 Jan;73(1):66-75. doi: 10.1111/j.1365-3083.2010.02477.x.
• 11. Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice.
  Bouike G, Nishitani Y, Shiomi H, Yoshida M, Azuma T, Hashimoto T, Kanazawa K, Mizuno M.Evid Based Complement Alternat Med. 2011;2011. doi:pii: 532180.  10.1155/2011/532180. Epub 2010 Sep 26.
• 12. Effect of Agaricus blazei Murill on the pulmonary tissue of animals with streptozotocin-induced diabetes.
  Di Naso FC, de Mello RN, Bona S, Dias AS, Porawski M, Ferraz Ade B, Richter MF, Marroni NP.Exp Diabetes Res. 2010;2010:543926. doi: 10.1155/2010/543926. Epub 2010 May 26.
• 13. Semipurified fractions from the submerged-culture broth of Agaricus blazei Murill reduce blood glucose levels in streptozotocin-induced diabetic rats.
  Oh TW, Kim YA, Jang WJ, Byeon JI, Ryu CH, Kim JO, Ha YL.J Agric Food Chem. 2010 Apr 14;58(7):4113-9. doi: 10.1021/jf9036672.
• 14. An extract based on the medicinal mushroom Agaricus blazei Murill stimulates monocyte-derived dendritic cells to cytokine and chemokine production in vitro.
  Førland DT, Johnson E, Tryggestad AM, Lyberg T, Hetland G.Cytokine. 2010 Mar;49(3):245-50. doi: 10.1016/j.cyto.2009.09.002. Epub 2009 Dec 24.
• 15. Effects of Agaricus blazei Murill extract on immune responses in normal BALB/c mice.
  Tang NY, Yang JS, Lin JP, Hsia TC, Fan MJ, Lin JJ, Weng SW, Ma YS, Lu HF, Shen JJ, Lin JG, Chung JG.In Vivo. 2009 Sep-Oct;23(5):761-6.
• 16. Immunostimulatory activities of a low molecular weight antitumoral polysaccharide isolated from Agaricus blazei Murill (LMPAB) in Sarcoma 180 ascitic tumor-bearing mice.
  Niu YC, Liu JC, Zhao XM, Su FQ, Cui HX.Pharmazie. 2009 Jul;64(7):472-6.
• 17. An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy.
  Ellertsen LK, Hetland G.Clin Mol Allergy. 2009 May 5;7:6. doi: 10.1186/1476-7961-7-6.
• 18. Effect of an extract based on the medicinal mushroom Agaricus blazei murill on release of cytokines, chemokines and leukocyte growth factors in human blood ex vivo and in vivo.
  Johnson E, Førland DT, Saetre L, Bernardshaw SV, Lyberg T, Hetland G.Scand J Immunol. 2009 Mar;69(3):242-50. doi: 10.1111/j.1365-3083.2008.02218.x.
• 19. Augmentation of sebaceous lipogenesis by an ethanol extract of Grifola frondosa (Maitake mushroom) in hamsters in vivo and in vitro.
  Nagao M, Sato T, Akimoto N, Kato Y, Takahashi M, Ito A.Exp Dermatol. 2009 Aug;18(8):730-3. doi: 10.1111/j.1600-0625.2008.00831.x. Epub 2009 Feb 18.
• 20. Tumoricidal effects of beta-glucans: mechanisms include both antioxidant activity plus enhanced systemic and topical immunity.
  Gu Y, Fujimiya Y, Itokawa Y, Oshima M, Choi JS, Miura T, Ishida T.Nutr Cancer. 2008;60(5):685-91. doi: 10.1080/01635580802030884.

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