Botanical Ingredient

Alpha-L-Rhamnose Safety Tips

Handling of Alpha-L-Rhamnose should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Lateral gene transfer between the Bacteroidetes and Acidobacteria: the case of α-L-rhamnosidases.
  Naumoff DG, Dedysh SN.FEBS Lett. 2012 Nov 2;586(21):3843-51. doi: 10.1016/j.febslet.2012.09.005. Epub 2012 Sep 26.
• 2. Mandelalides A-D, cytotoxic macrolides from a new Lissoclinum species of South African tunicate.
  Sikorska J, Hau AM, Anklin C, Parker-Nance S, Davies-Coleman MT, Ishmael JE, McPhail KL.J Org Chem. 2012 Jul 20;77(14):6066-75. doi: 10.1021/jo3008622. Epub 2012 Jul 3.
• 3. Preparation, structure and anticoagulant activity of a low molecular weight fraction produced by mild acid hydrolysis of sulfated rhamnan from Monostroma latissimum.
  Li H, Mao W, Hou Y, Gao Y, Qi X, Zhao C, Chen Y, Chen Y, Li N, Wang C.Bioresour Technol. 2012 Jun;114:414-8. doi: 10.1016/j.biortech.2012.03.025. Epub 2012 Mar 14.
• 4. Studies on the conformational flexibility of α-L-rhamnose-containing oligosaccharides using 13C-site-specific labeling, NMR spectroscopy, and molecular simulations: implications for the three-dimensional structure of bacterial rhamnan polysaccharides.
  Jonsson KH, Säwén E, Widmalm G.Org Biomol Chem. 2012 Mar 28;10(12):2453-63. doi: 10.1039/c2ob06924e. Epub 2012 Feb 17.
• 5. Updates on naringinase: structural and biotechnological aspects.
  Puri M.Appl Microbiol Biotechnol. 2012 Jan;93(1):49-60. doi: 10.1007/s00253-011-3679-3. Epub 2011 Nov 13. Review.
• 6. The cephalostatins. 21. Synthesis of bis-steroidal pyrazine rhamnosides (1).
  Pettit GR, Mendonça RF, Knight JC, Pettit RK.J Nat Prod. 2011 Sep 23;74(9):1922-30. doi: 10.1021/np200411p. Epub 2011 Sep 7.
• 7. Structure and host recognition of serotype 13 glycopeptidolipid from Mycobacterium intracellulare.
  Naka T, Nakata N, Maeda S, Yamamoto R, Doe M, Mizuno S, Niki M, Kobayashi K, Ogura H, Makino M, Fujiwara N.J Bacteriol. 2011 Oct;193(20):5766-74. doi: 10.1128/JB.05412-11. Epub 2011 Aug 19.
• 8. Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents.
  Wang HY, Rojanasakul Y, O’Doherty GA.ACS Med Chem Lett. 2011 Apr 14;2(4):264-269.
• 9. Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
  Wang HY, Xin W, Zhou M, Stueckle TA, Rojanasakul Y, O’Doherty GA.ACS Med Chem Lett. 2011 Jan 13;2(1):73-78.
• 10. C5′-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.
  Wang HY, Qi Z, Wu B, Kang SW, Rojanasakul Y, O’Doherty GA.ACS Med Chem Lett. 2011 Apr 14;2(4):259-263.
• 11. Triterpenoid saponins from Symplocos lancifolia.
  Acebey-Castellon IL, Voutquenne-Nazabadioko L, Doan Thi Mai H, Roseau N, Bouthagane N, Muhammad D, Le Magrex Debar E, Gangloff SC, Litaudon M, Sevenet T, Hung NV, Lavaud C.J Nat Prod. 2011 Feb 25;74(2):163-8. doi: 10.1021/np100502y. Epub 2011 Feb 2.
• 12. Synthesis and anti-fungal activity of seven oleanolic acid glycosides.
  Zhao H, Zong G, Zhang J, Wang D, Liang X.Molecules. 2011 Jan 26;16(2):1113-28. doi: 10.3390/molecules16021113.
• 13. Two new flavone glycosides from the seeds of Impatiens balsamina L.
  Lei J, Qian SH, Jiang JQ.J Asian Nat Prod Res. 2010 Dec;12(12):1033-7. doi: 10.1080/10286020.2010.532315.
• 14. Exopolysaccharide analysis of biofilm-forming Candida albicans.
  Lal P, Sharma D, Pruthi P, Pruthi V.J Appl Microbiol. 2010 Jul;109(1):128-36. doi: 10.1111/j.1365-2672.2009.04634.x. Epub 2009 Nov 23.
• 15. Production of diosgenin from Dioscorea zingiberensis tubers  through enzymatic saccharification and microbial  transformation.
  Zhu YL, Huang W, Ni JR, Liu W, Li H.Appl Microbiol Biotechnol. 2010 Feb;85(5):1409-16. doi: 10.1007/s00253-009-2200-8.
• 16. Structure elucidation and complete NMR spectral assignments of two new oleanane-type pentacyclic triterpenoid saponins from the husks of Xanthoceras sorbifolia Bunge.
  Guo Y, Dou DQ, Kang TG, Wang SC, Kuang HX.Magn Reson Chem. 2009 Nov;47(11):982-8. doi: 10.1002/mrc.2479.
• 17. Chemical structure and antiviral activity of the sulfated heterorhamnan isolated from the green seaweed Gayralia oxysperma.
  Cassolato JE, Noseda MD, Pujol CA, Pellizzari FM, Damonte EB, Duarte ME.Carbohydr Res. 2008 Dec 8;343(18):3085-95. doi: 10.1016/j.carres.2008.09.014. Epub 2008 Sep 24.
• 18. The alpha-L-Rhamnose recognizing lectin site of human dermal fibroblasts functions as a signal transducer: modulation of Ca2+ fluxes and gene expression.
  Faury G, Ruszova E, Molinari J, Mariko B, Raveaud S, Velebny V, Robert L.Biochim Biophys Acta. 2008 Dec;1780(12):1388-94. doi: 10.1016/j.bbagen.2008.07.008. Epub 2008 Jul 28.
• 19. Structural analysis and biosynthesis gene cluster of an antigenic glycopeptidolipid from Mycobacterium intracellulare.
  Fujiwara N, Nakata N, Naka T, Yano I, Doe M, Chatterjee D, McNeil M, Brennan PJ, Kobayashi K, Makino M, Matsumoto S, Ogura H, Maeda S.J Bacteriol. 2008 May;190(10):3613-21. doi: 10.1128/JB.01850-07. Epub 2008 Mar 7.
• 20. Evidence for a Grotthuss-like mechanism in the formation of the rhamnose alkoxy radical based on periodic DFT calculations.
  Pauwels E, Declerck R, Speybroeck VV, Waroquier M.Radiat Res. 2008 Jan;169(1):8-18.

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