Botanical Ingredient

Andrographolide Safety Tips

Handling of Andrographolide should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Inhibition of matrix metalloproteinases and inducible nitric oxide synthase by andrographolide in human osteoarthritic chondrocytes.
  Ding QH, Ji XW, Cheng Y, Yu YQ, Qi YY, Wang XH.Mod Rheumatol. 2012 Dec 15. [Epub ahead of print]
• 2. Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells.
  He CL, Yi PF, Fan QJ, Shen HQ, Jiang XL, Qin QQ, Song Z, Zhang C, Wu SC, Wei XB, Li YL, Fu BD.Immunopharmacol Immunotoxicol. 2012 Nov 21. [Epub ahead of print]
• 3. Regio- and Stereoselective Synthesis of a Library of Bioactive Dispiro-Oxindolo/Acenaphthoquino Andrographolides via 1,3-Dipolar Cycloaddition Reaction Under Microwave Irradiation.
  Hazra A, Bharitkar YP, Chakraborty D, Mondal SK, Singal N, Mondal S, Maity A, Paira R, Banerjee S, Mondal NB.ACS Comb Sci. 2012 Nov 29. [Epub ahead of print]
• 4. A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism.
  Zhu YY, Yu G, Zhang Y, Xu Z, Wang YQ, Yan GR, He QY.Proteomics. 2012 Nov 17. doi: 10.1002/pmic.201200273. [Epub ahead of print]
• 5. Platelet-activating factor (PAF)-antagonists of natural origin.
  Singh P, Singh IN, Mondal SC, Singh L, Garg VK.Fitoterapia. 2012 Nov 16. doi:pii: S0367-326X(12)00295-X.  10.1016/j.fitote.2012.11.002. [Epub ahead of print]
• 6. Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity.
  Guan S, Tee W, Ng D, Chan T, Peh H, Ho W, Cheng C, Mak J, Wong W.Br J Pharmacol. 2012 Nov 12. doi: 10.1111/bph.12054. [Epub ahead of print]
• 7. [Preliminary study of effects of andrographolide on Staphylococcus epidermidis biofilms].
  Guan Y, Zhang J, Wang C, Wang N, Liu Z, Shi J.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(14):2147-50. Chinese.
• 8. Nanoparticle engineering enhances anticancer efficacy of andrographolide in MCF-7 cells and mice bearing EAC.
  Roy P, Das S, Mondal A, Chatterji U, Mukherjee A.Curr Pharm Biotechnol. 2012 Oct 9. [Epub ahead of print]
• 9. Cell type-dependent effects of andrographolide on human cancer cell lines.
  Cheung MT, Ramalingam R, Lau KK, Chiang WL, Chiu SK.Life Sci. 2012 Oct 22;91(15-16):751-760. doi: 10.1016/j.lfs.2012.04.009. No abstract available.
• 10. Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways.
  Guo W, Liu W, Chen G, Hong S, Qian C, Xie N, Yang X, Sun Y, Xu Q.Int Immunopharmacol. 2012 Dec;14(4):613-9. doi: 10.1016/j.intimp.2012.09.002. Epub 2012 Oct 1.
• 11. Antioxidative and cytoprotective effects of andrographolide against CCl4-induced hepatotoxicity in HepG2 cells.
  Krithika R, Verma R, Shrivastav P.Hum Exp Toxicol. 2012 Sep 27. [Epub ahead of print]
• 12. Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetics.
  Zhang SQ, Fan YM.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 15;907:173-7. doi: 10.1016/j.jchromb.2012.09.013. Epub 2012 Sep 12.
• 13. Elicitation of Andrographolide in the Suspension Cultures of Andrographis paniculata.
  Gandi S, Rao K, Chodisetti B, Giri A.Appl Biochem Biotechnol. 2012 Dec;168(7):1729-38. doi: 10.1007/s12010-012-9892-4. Epub 2012 Sep 23.
• 14. Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis.
  Guo SW, Mao X, Ma Q, Liu X.Fertil Steril. 2012 Sep 19. doi:pii: S0015-0282(12)02126-7.  10.1016/j.fertnstert.2012.08.038. [Epub ahead of print]
• 15. A Green Method Using a Micellar System for Determination of Andrographolide and Dehydroandrographolide in Human Plasma.
  Zhao Q, Ding J, Jin H, Ding L, Ren N.J Chromatogr Sci. 2012 Sep 12. [Epub ahead of print]
• 16. Quinone reductase (QR) inducers from Andrographis paniculata and identification of molecular target of andrographolide.
  Yuan Y, Ji L, Luo L, Lu J, Ma X, Ma Z, Chen Z.Fitoterapia. 2012 Dec;83(8):1506-13. doi: 10.1016/j.fitote.2012.08.018. Epub 2012 Sep 1.
• 17. A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer.
  Saranya P, Geetha A, Selvamathy SM.Indian J Pharm Sci. 2011 Sep;73(5):550-7. doi: 10.4103/0250-474X.99012.
• 18. Inhibition of topoisomerase II α activity and induction of apoptosis in mammalian cells by semi-synthetic andrographolide analogues.
  Nateewattana J, Saeeng R, Kasemsook S, Suksen K, Dutta S, Jariyawat S, Chairoungdua A, Suksamrarn A, Piyachaturawat P.Invest New Drugs. 2012 Aug 17. [Epub ahead of print]
• 19. In Vitro Comparative Evaluation of Non-Leaves and Leaves Extracts of Andrographis paniculata on Modulation of Inflammatory Mediators.
  Chandrasekaran CV, Murali B, Deepak M, Agarwal A.Antiinflamm Antiallergy Agents Med Chem. 2012 Sep 1;11(2):191-7.
• 20. Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore.
  Chen W, Feng L, Nie H, Zheng X.Carcinogenesis. 2012 Nov;33(11):2190-8. doi: 10.1093/carcin/bgs264. Epub 2012 Aug 6.

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