Botanical Ingredient

Artesunate Safety Tips

Handling of Artesunate should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Severe falciparum malaria with dengue coinfection complicated by rhabdomyolysis and acute kidney injury: an unusual case with myoglobinemia, myoglobinuria but normal serum creatine kinase.
  Yong KP, Tan BH, Low CY.BMC Infect Dis. 2012 Dec 20;12(1):364. [Epub ahead of print]
• 2. Dynamic deformability of Plasmodium falciparum-infected erythrocytes exposed to artesunate in vitro.
  Huang S, Undisz A, Diez-Silva M, Bow H, Dao M, Han J.Integr Biol (Camb). 2012 Dec 19. [Epub ahead of print]
• 3. Randomized, Open Label Trial of Primaquine Against Vivax Malaria Relapse in Indonesia.
  Sutanto I, Tjahjono B, Basri H, Taylor WR, Putri FA, Meilia RA, Setiabudy R, Nurleila S, Ekawati LL, Elyazar I, Farrar J, Sudoyo H, Baird JK.Antimicrob Agents Chemother. 2012 Dec 17. [Epub ahead of print]
• 4. Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models.
  Cheng C, Ng DS, Chan TK, Guan SP, Ho WE, Koh AH, Bian JS, Lau HY, Wong WS.Allergy. 2012 Dec 18. doi: 10.1111/all.12077. [Epub ahead of print]
• 5. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia.
  Takala-Harrison S, Clark TG, Jacob CG, Cummings MP, Miotto O, Dondorp AM, Fukuda MM, Nosten F, Noedl H, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Socheat D, Ariey F, Phyo AP, Starzengruber P, Fuehrer HP, Swoboda P, Stepniewska K, Flegg J, Arze C, Cerqueira GC, Silva JC, Ricklefs SM, Porcella SF, Stephens RM, Adams M, Kenefic LJ, Campino S, Auburn S, Macinnis B, Kwiatkowski DP, Su XZ, White NJ, Ringwald P, Plowe CV.Proc Natl Acad Sci U S A. 2012 Dec 17. [Epub ahead of print]
• 6. Antimalarial activity of 10-alkyl/aryl esters and -aminoethylethers of artemisinin.
  Cloete TT, Krebs HJ, Clark JA, Connelly MC, Orcutt A, Sigal MS, Kiplin Guy R, N’da DD.Bioorg Chem. 2012 Nov 3;46C:10-16. doi: 10.1016/j.bioorg.2012.10.002. [Epub ahead of print]
• 7. Electrocardiographic study in Ghanaian children with uncomplicated malaria, treated with artesunate-amodiaquine or artemether-lumefantrine.
  Adjei GO, Oduro-Boatey C, Rodrigues OP, Hoegberg LC, Alifrangis M, Kurtzhals JA, Goka BQ.Malar J. 2012 Dec 17;11(1):420. [Epub ahead of print]
• 8. Efficacy and tolerability of a new formulation of artesunate-mefloquine for the treatment of uncomplicated malaria in adult in Senegal: open randomized trial.
  Tine RC, Faye B, Sylla K, Ndiaye JL, Ndiaye M, Sow D, Lo AC, Abiola A, Ba MC, Gaye O.Malar J. 2012 Dec 12;11(1):416. [Epub ahead of print]
• 9. Quantitative screening for anti-cestode drugs based upon changes in baseline enzyme secretion by Taenia crassiceps.
  Mahanty S, Madrid EM, Nash TE.Antimicrob Agents Chemother. 2012 Dec 10. [Epub ahead of print]
• 10. The effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase-2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania.
  Hodel EM, Csajka C, Ariey F, Guidi M, Kabanywanyi AM, Duong S, Decosterd LA, Olliaro P, Beck HP, Genton B.Antimicrob Agents Chemother. 2012 Dec 10. [Epub ahead of print]
• 11. In vitro anti-plasmodial activity of three herbal remedies for malaria in Ghana: Adenia cissampeloides (Planch.) Harms., Termina liaivorensis A. Chev, and Elaeis guineensis Jacq.
  Annan K, Sarpong K, Asare C, Dickson R, Amponsah K, Gyan B, Ofori M, Gbedema S.Pharmacognosy Res. 2012 Oct;4(4):225-9. doi: 10.4103/0974-8490.102270.
• 12. Artesunate and its emerging anti-neoplastic effects: beyond its role in attenuating tumor growth in osteosarcomas.
  Kapoor S.J Zhejiang Univ Sci B. 2012 Dec;13(12):1029-30. doi: 10.1631/jzus.B1200288. No abstract available.
• 13. Efficacy and safety of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in endemic countries: meta-analysis of randomised controlled studies.
  Naing C, Mak JW, Aung K, Wong JY.Trans R Soc Trop Med Hyg. 2012 Dec 4. [Epub ahead of print]
• 14. Application of loop-mediated isothermal amplification for malaria diagnosis during a follow-up study in Sao Tome.
  Lee PW, Ji DD, Liu CT, Rampao HS, do Rosario VE, Lin IF, Shaio MF.Malar J. 2012 Dec 6;11(1):408. [Epub ahead of print]
• 15. Anti-malarial drug safety information obtained through routine monitoring in a rural district of South-Western Senegal.
  Brasseur P, Vaillant MT, Olliaro PL.Malar J. 2012 Dec 5;11(1):402. [Epub ahead of print]
• 16. Assessing the cost-benefit effect of a Plasmodium falciparum drug resistance mutation on parasite growth in vitro.
  Fröberg G, Ferreira PE, Mårtensson A, Ali A, Björkman A, Gil JP.Antimicrob Agents Chemother. 2012 Dec 3. [Epub ahead of print]
• 17. Severe imported Falciparum malaria treated with artesunate.
  Danguy des Déserts M, Montelescaut E, Di Costanzo L, Commandeur D, Nguyen BV, Ould-Ahmed M, Taudon N, Drouillard I.Ann Biol Clin (Paris). 2012 Dec 1;70(6):733-740.
• 18. Malaria patient CYP2C8 status influences selection of P. falciparum pfmdr1 alleles after amodiaquine-artesunate treatment.
  Cavaco I, Mårtensson A, Fröberg G, Mselllem M, Björkman A, Gil JP.J Infect Dis. 2012 Nov 30. [Epub ahead of print] No abstract available.
• 19. Chemotherapeutic Strategies for Reducing Transmission of Plasmodium vivax Malaria.
  Douglas NM, John GK, von Seidlein L, Anstey NM, Price RN.Adv Parasitol. 2012;80:271-300. doi: 10.1016/B978-0-12-397900-1.00005-0.
• 20. Malaria and the heart.
  Bhat S, Alva J, Muralidhara K, Fahad S.BMJ Case Rep. 2012 Nov 27;2012. doi:pii: bcr2012007275.  10.1136/bcr-2012-007275.